Effect of serotonin on respiration, cerebral circulation, and blood pressure in rats

Александрин, В. В.; Tarasova, N. N.; Tarakanov, I. A.

doi:10.1007/s10517-005-0213-6

Cited by 3 publications

(2 citation statements)

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“…However, endogenous adenosine may be involved in the mechanism of a secondary suppression of the hypoxic activation of the cerebral blood flow. As mentioned above, the fall in the rate of cerebral blood flow under the von Bezold-Jarisch reflex conditions also occurred after the apnoea beginning in the background of its end and coincided with the accumulation of CO 2 in the blood [61]. Under severe hypoxia (8% O 2 , rat), i.v.…”

Section: Adenosinergic Systemmentioning

confidence: 75%

See 1 more Smart Citation

Hypoxic Preconditioning: The Multiplicity of Central Neurotransmitter Mechanisms and Method of Predicting Its Efficiency

Захарова¹,

Storozheva²,

Proshin³

et al. 2018

Hypoxia and Anoxia

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In rats, a single moderate hypobaric hypoxia (HBH) increased the resistance to severe hypoxia (SHBH). The HBH efficiency and neurotransmitter mechanisms of its preconditioning action were investigated by biochemical and pharmacological methods. It will be substantiated in the chapter: (1) HBH preconditioning has its own mechanisms that do not depend on an innate resistance to SHBH and prior hypoxic experience of rats; (2) the same preconditioning effect can be achieved by diverse neuronal pathways and synaptic plasticity means; (3) cholinergic and, presumably, serotoninergic, GABAergic and/or glutamatergic systems of the caudal brainstem, cortex and some other brain structures are involved in HBH realisation; (4) the rate of sensorimotor gating estimated in the model of acoustic startle pre-pulse inhibition (PPI) predicts the efficiency of hypoxic preconditioning and (5) the cholinergic system, including α7 nicotinic receptors, is involved in the mechanisms of HBH-PPI-dependent preconditioning effects.

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Section: Adenosinergic Systemmentioning

confidence: 75%

“…Also, by i.v. administration of 5-HT, a significant drop in the rate of the cerebral circulation was revealed in the cortical parietal area as well as in the frequency and depth of breathing [61]. The drop in the rate of the cerebral circulation coincided with the accumulation of CO 2 in the blood.…”

Section: Serotoninergic Systemmentioning

confidence: 88%