Effect of septal lesions on learning, emotionality, activity, and exploratory behavior in rats

Nielson, Harold C.; McIver, Anstiss H.; Boswell, Reed S.

doi:10.1016/0014-4886(65)90009-9

Cited by 86 publications

(23 citation statements)

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“…This well-known, gross behavioural change, often termed 'septal rage' or ' septal hyper-reactivity ',* was observed several decades ago (Fulton & Ingraham, 1929) and has since been reported by many workers (e.g. Brady & Nauta, 1953, 1955Douglas & Raphelson, 1966;Harrison & Lyon, 1957;Nielson et al, 1965;Reynolds, 1965). Hyper-reactivity has also been found in the rabbit following combined septal and hippocampal damage (Green & Arduini, 1954), in the cat after destruction of the septum (Spiegel et al, 1940) and in humans with tumours of the septum pellucidum (Zeman & King, 1958).…”

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confidence: 91%

“…Considerable work has been directed at establishing the stimulus variables and anatomical structures which initiate or suppress this behaviour. Several investigators have reported that hyper-emotionality dissipates with time (Brady & Nauta, 1953;Nielson et al, 1965;Reynolds, 1965). However, it appears that the attenuation of septal rage is more likely due to pre-and post-operative factors than the passage of time per se.…”

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confidence: 99%

“…In three studies in which considerable preoperative handling occurred, Fried (1969,1970,1971) found septal rage in less than 10 per cent of the subjects, with the rage dissipating by the seventh post-operative day. It has been proposed that handling may enable rats to adapt better to testing procedures used in assessing hyper-emotionality because of experience in general stimulation (Nielson et al, 1965).…”

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confidence: 99%

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The Septum and Hyper‐reactivity: A Review

Fried

1973

British J of Psychology

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The literature related to one form of septal dysfunction ‐ hyper‐reactivity ‐ is reviewed. The increase in reactivity following septal damage is considered in terms of its reliability and the many factors which influence its attenuation and release. Research discussed includes the topics of anatomical locus of septal damage, species and strain investigated, pre‐ and post‐operative handling, neurochemical factors, and the relationship of hyper‐reactivity to other septal dysfunctions and other anatomical structures.

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The Septum and Hyper‐reactivity: A Review

Fried

1973

British J of Psychology

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“…Most investigators who have reported measures of duration for various facets of the septal syndrome have indicated recovery periods of less than 60 days (Brady & Nauta, 1955;King, 1958;Nielson, Mciver, & Boswell, 1965), although others have observed manifestations of the lesion at 70-110 days (Harvey & Lints, 1971;Krieckhaus, Simmons, Thomas, & Kenyon, 1964). Experiment 2 was conducted to determine whether animals recover from the passive avoidance deficits produced by MS lesions and to evaluate the effects of stimulus variables on the recovery process.…”

Section: Methodsmentioning

confidence: 99%

Long-term and environmental effects of medial septal lesions in rats

Miller

Christensen

1980

Psychobiology

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One of the difficulties encountered in attempts to underestand the process of recovery following damage of the septal nuclei is that a variety of disorders are produced by the damage and that not all seem to recover at similar rates. It has been suggested that environmental conditions influence recovery such that rates may be either increased or attenuated. In the present study, the passive avoidance deficit that follows lesion of the medial septal nuclei in rats was observed for periods of 20 and 70 days. The damage produced marked passive avoidance deficits that were observed at 20 days but not at 70 days. Although lesion subjects rapidly acquired the passive avoidance response at 70 days, their learning patterns were unlike those of control subjects, suggesting acquisition via different neural substrates. Moreover, tests for retention of the passive avoidance task revealed retention deficits in all lesion subjects. Two groups of subjects were allowed to recover for 70 days, one housed in a high-stimulus environment and the other in a low-stimulus environment. Effects of environment on recover~! from lesions were not detected. However, comparisons of normally housed subjects with those housed in the high-and low-stimulus environments showed that the lowstimulus environment produced passive avoidance deficits primarily in control subjects. The findings are discussed within a framework of specific and nonspecific arousal.

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“…The active avoidance apparatus was a T maze with a grid floor and a lever in each arm of the T (for details of the T maze see Nielson, McIver, & Boswell, 1965). Five sec after the door of the start box opened, a loud buzzer and foot shock came on.…”

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confidence: 99%