Effect of semisynthetic analog of α1-acid glycoprotein on immunomodulatory and antiinflammatory activity of natural glycoproteinglycoprotein on immunomodulatory and antiinflammatory activity of natural glycoprotein

Pukhal'skii, A. L.; Shmarina, Galina; Калашникова, Е. А.; Shiyan, S. D.; Кокаровцева, С. Н.; Pukhalskaya, Daria; Bovin, Nicolai V.

doi:10.1007/bf02439809

Cited by 8 publications

(10 citation statements)

References 11 publications

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“…Pukhal'skii et al reported that human AGP inhibits neutrophil superoxide anion generation and suggested that the antioxidant activity of AGP is due to the binding of free radicals, rather than to the inhibition of neutrophil activation. 13) The data obtained here support this proposal. Based on this mechanism, it is possible that AGP prevents the oxidation of DRD to RD from H 2 O 2 ( Table 2).…”

Section: Discussionsupporting

confidence: 82%

“…We also investigated the effects of AGP on the oxidative changes in erythrocytes exposed to oxygen radicals, because AGP has been reported to inhibit neutrophil aggregation and superoxide anion generation induced by formyl-methionyl-leucyl-phenylalanine, phorbol myristate acetate 12) and phytohemagglutinin. 13) These studies were carried out using AGP and desialylated AGP to determine the role of sialic acid in this process.…”

mentioning

confidence: 99%

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Effects of .ALPHA.1-Acid Glycoprotein on Erythrocyte Deformability and Membrane Stabilization.

Matsumoto

Nishi

Tokutomi

et al. 2003

Biological & Pharmaceutical Bulletin

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Section: Discussionsupporting

confidence: 82%

mentioning

confidence: 99%

Effects of .ALPHA.1-Acid Glycoprotein on Erythrocyte Deformability and Membrane Stabilization.

Matsumoto

Nishi

Tokutomi

et al. 2003

Biological & Pharmaceutical Bulletin

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“…40) However, fMLP might activate protein kinase C (PKC) receptors existed in neutrophils but PMA might directly activate for PKC. PKC phosphorylates and activates NADPH oxidase, resulting in the generation of superoxide anion.…”

Section: Discussionmentioning

confidence: 99%

.ALPHA.1-Acid Glycoprotein Suppresses Rat Acute Inflammatory Paw Edema through the Inhibition of Neutrophils Activation and Prostaglandin E2 Generation

Matsumoto

Nishi

Kikuchi

et al. 2007

Biological & Pharmaceutical Bulletin

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“…The cytokines, in turn, modulate T-cell proliferation and function (29,58). Because of the immunomodulatory potential associated with the carbohydrates of the AAG glycoforms, these molecules, or pseudo-glycoproteins mimicking their activity, represent molecules with pharmacological potential for modulation or prevention of atherogenesis-promoting processes (51,58).…”

Section: Discussionmentioning

confidence: 99%

Systemic Inflammation in Cardiovascular and Periodontal Disease: Comparative Study

Glurich¹,

Grossi²,

Albini

et al. 2002

Clin Vaccine Immunol

123

131

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Epidemiological studies have implicated periodontal disease (PD) as a risk factor for the development of cardiovascular disease (CVD). These studies addressed the premise that local infection may perturb the levels of systemic inflammatory mediators, thereby promoting mechanisms of atherosclerosis. Levels of inflammatory mediators in the sera of subjects with only PD, only CVD, both diseases, or neither condition were compared. Subjects were assessed for levels of C-reactive protein (CRP), serum amyloid A (SAA), ceruloplasmin, ␣ 1 -acid-glycoprotein (AAG), ␣ 1 -antichymotrypsin (ACT), and the soluble cellular adhesion molecules sICAM-1 and sVCAM by enzyme-linked immunoabsorbent and/or radial immunodiffusion assays. CRP levels in subjects with either condition alone were elevated twofold above subjects with neither disease, whereas a threefold increase was noted in subjects with both diseases (P ‫؍‬ 0.0389). Statistically significant increases in SAA and ACT were noted in subjects with both conditions compared to those with one or neither condition (P ‫؍‬ 0.0162 and 0.0408, respectively). Ceruloplasmin levels were increased in subjects with only CVD (P ‫؍‬ 0.0001). Increases in sVCAM levels were noted in all subjects with CVD (P ‫؍‬ 0.0054). No differences in sICAM levels were noted among subject groups. A trend toward higher levels of AAG was noted in subjects with both conditions and for ACT in subjects with only PD. Immunohistochemical examination of endarterectomy specimens of carotid arteries from subjects with atherosclerosis documented SAA and CRP deposition in association with atheromatous lesions. The data support the hypothesis that localized persistent infection may influence systemic levels of inflammatory mediators. Changes in inflammatory mediator levels potentially impact inflammation-associated atherosclerotic processes.Hypercholesterolemia, lipid metabolism imbalances, hypertension, age, gender, body mass index, diabetes mellitus, homocysteine, stress, and smoking are widely accepted as "classic" risk factors for development of cardiovascular disease (CVD). However, it has also become clear that the contribution of these factors cannot be supported in 25 to 50% of subjects who develop CVD and cerebrovascular disease (39, 53). These observations have intensified initiatives to identify additional risk factors for the development of atherosclerosis and vascular ischemic diseases. Recent evidence indicates that the development of CVD correlates with elevated levels of C-reactive protein (CRP) (25,30,35,45,54,55) and soluble cellular adhesion molecules (CAM) (27,48,56,76) which are produced in response to cellular damage. These observations have led to a reexamination of one of the earliest theories regarding the etiology of atherosclerosis and coronary heart disease (CHD): inflammatory processes which may arise in association with infection (39, 42).In the mid-1800s, Virchow drew attention to the presence of two distinct lesions along arterial vessel walls: the classical "fatty streak" and a second ...

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Effect of semisynthetic analog of α1-acid glycoprotein on immunomodulatory and antiinflammatory activity of natural glycoproteinglycoprotein on immunomodulatory and antiinflammatory activity of natural glycoprotein

Cited by 8 publications

References 11 publications

Effects of .ALPHA.1-Acid Glycoprotein on Erythrocyte Deformability and Membrane Stabilization.

Effects of .ALPHA.1-Acid Glycoprotein on Erythrocyte Deformability and Membrane Stabilization.

.ALPHA.1-Acid Glycoprotein Suppresses Rat Acute Inflammatory Paw Edema through the Inhibition of Neutrophils Activation and Prostaglandin E2 Generation

Systemic Inflammation in Cardiovascular and Periodontal Disease: Comparative Study

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