Effect of selenium supplementation on changes in HbA1c: Results from a multiple‐dose, randomized controlled trial

Stranges, Saverio; Rayman, Margaret P.; Winther, Kristian Hillert; Güallar, Eliseo; Cold, Søren; Pastor-Barriuso, Roberto

doi:10.1111/dom.13549

Cited by 21 publications

(18 citation statements)

References 41 publications

(148 reference statements)

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“…Two RCTs on selenium supplementation carried out in Danish elderly and Polish adults reinforce our main result that higher intakes of selenium are associated with lower concentrations of HbA 1c , even within different populations and with different doses of selenium ( 16 , 38 ). By contrast, some studies have failed to demonstrate a decrease in HbA 1c concentrations ( 12 , 39 ) or found high serum selenium concentrations associated with increased concentrations of glucose and HbA 1c , as in 41,474 American adults with a mean dietary selenium intake of 98.0 ± 55.0 μg/day ( 40 ) and in 8,824 Chinese with a mean consumption of 52.4 μg/day ( 41 ).…”

Section: Discussionsupporting

confidence: 66%

Selenium Intake and Glycemic Control in Young Adults With Normal-Weight Obesity Syndrome

et al. 2021

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Numerous endogenous functions related to antioxidant processes, reproduction, and thyroid metabolism, as well as actions related to glycemic control, have been attributed to selenium. This study aimed to evaluate whether dietary selenium consumption is associated with variables of glycemic control in a sample of young Brazilian adults with Normal-Weight Obesity (NWO) syndrome. This was a cross-sectional study that evaluated 270 individuals with adequate body weight and excess body fat, who had their body composition assessed by dual-energy X-ray absorptiometry. Socioeconomic, health, and lifestyle questionnaires and three 24-h food records were applied. Glycemic control markers were also evaluated. The prevalence of inadequate selenium intake was analyzed by the Estimated Average Requirement (EAR) cut-point method. The prevalence of disturbances in glycemic control markers according to selenium consumption was compared by either the chi-square or the Fisher's exact test, with individuals classified according to the EAR values for selenium. The associations were evaluated by multiple linear regressions, using the backward strategy. The mean ± standard deviation (SD) age was 23.7 ± 3.3 years, and the mean ± SD daily selenium intake was 59.2 ± 26.4 μg. The overall prevalence of inadequate selenium intake was 59.2%. Individuals with selenium intakes below the EAR (≤45 μg/day) showed higher concentrations of glycated hemoglobin (HbA1c) (P = 0.002) and a higher prevalence of disturbances in HbA1c than those with selenium intakes above the EAR (>45 μg/day) (P = 0.001). Dietary selenium intake was directly associated with female sex (β = 19.95, 95% CI 5.00 to 34.89; P = 0.001) and weight (β = 6.69, 95% CI 0.56 to 12.81; P = 0.010), and inversely associated with the percentage of total body fat (β = −0.80, 95% CI −1.56 to −0,04; P = 0.010) and HbA1c (β = −7.41, 95% CI −13.06 to −1.75; P = 0.010). Considering the noticeable young age of the individuals evaluated and the high frequency of disturbances in HbA1c concentrations in those with selenium consumption below the recommendation, it is suggested that adequate dietary intake or supplementation of this micronutrient should be guaranteed to prevent future possible complications associated with glycemic control disturbances.

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Section: Discussionsupporting

confidence: 66%

Selenium Intake and Glycemic Control in Young Adults With Normal-Weight Obesity Syndrome

et al. 2021

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“…Therefore, long term supplementation needs special attention and it might be recommended to monitor glycemia after a few weeks. However, recent studies have been reassuring regarding dosages < 300 mcg notably for type 2 diabetes and prostate cancer (121)(122)(123)(124)(125). Long term 200 mcg Selenium supplementation in randomized controlled trials in HIV infection has been shown to be well-tolerated (24)(25)(26).…”

Section: Discussionmentioning

confidence: 99%

Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)

Hiffler¹,

Rakotoambinina

2020

Front. Nutr.

104

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SARS-CoV-2 is an RNA virus responsible for the COVID-19 pandemic that already claimed more than 340,000 lives worldwide as of May 23, 2020, the majority of which are elderly. Selenium (Se), a natural trace element, has a key and complex role in the immune system. It is well-documented that Se deficiency is associated with higher susceptibility to RNA viral infections and more severe disease outcome. In this article, we firstly present evidence on how Se deficiency promotes mutations, replication and virulence of RNA viruses. Next, we review how Se might be beneficial via restoration of host antioxidant capacity, reduction of apoptosis and endothelial cell damages as well as platelet aggregation. It also appears that low Se status is a common finding in conditions considered at risk of severe COVID-19, especially in the elderly. Finally, we present a rationale for Se use at different stages of COVID-19. Se has been overlooked but may have a significant place in COVID-19 spectrum management, particularly in vulnerable elderly, and might represent a game changer in the global response to COVID-19.

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“…Briefly, plasma samples (50 µL) were diluted 1:100 in a diluent containing; Triton-X-100 (0.05%), ammonium hydroxide (NH 4 OH) (1%), ethylenediaminetetraacetic Acid (EDTA; 0.05%), and Butanol (2%) (Sigma-Aldrich, Taufkirchen, Germany). Butanol was added to compensate for differences in carbon content between the samples and standards that may cause variances in ionization efficiency leading to erroneous results [ 63 , 64 ]. Rhodium (Rh) was used as an internal standard for accuracy to correct for any instrumental drift.…”

Section: Methodsmentioning

confidence: 99%

The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data

et al. 2021

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Cardiometabolic risk (CMR) factors increase the likelihood of developing cardiovascular diseases (CVD). In Qatar, 24% of the total deaths are attributed to CVDs. Several nutritional disturbances have been linked to high risk of CVD. Many studies have discussed the effects of zinc (Zn) and copper (Cu) on CMR factors; however, evidence has been controversial. This investigated the association between CMR factors and the status of Zn and Cu, in addition to Zn/Cu ratio. A total of 575 Qatari men and women aged 18 years and older were obtained from Qatar Biobank. Plasma levels of Zn and Cu were determined using inductively coupled plasma mass spectrometry (ICP-MS). Anthropometric data and CMR factors were determined using standard methods. Adjusted associations between trace minerals and CMR were estimated by logistic regression. Partial correlation was performed to test the strength of the associations. Zn was not strongly correlated (p-value ˃ 0.01) or significantly associated with CMR factors and metabolic syndrome (MetS). Cu levels correlated positively with body mass index (BMI) (0.23; p ˂ 0.001), pulse rate (PR) (0.18; p ˂ 0.001), total cholesterol (0.13; p = 0.01), and high-density lipoproteins (HDL) (0.27; p ˂ 0.001); and negatively with diastolic blood pressure (DBP) (−0.13; p = 0.01). High plasma Cu significantly decreased the risk of metabolic syndrome (MetS) (0.121; p ˂ 0.001). Furthermore, Zn/Cu ratio positively correlated with waist circumference (0.13; p = 0.01), systolic blood pressure (0.13; p ˂ 0.01), and DBP (0.14; p ˂ 0.01); and negatively with BMI (−0.19; p ˂ 0.001), PR (−0.17; p ˂ 0.001), and HDL (−0.27; p ˂ 0.001). High Zn/Cu ratio increased the prevalence of low HDL (4.508; p ˂ 0.001) and MetS (5.570; p ˂ 0.01). These findings suggest that high plasma Cu levels are associated with a protective effect on DBP, HDL and MetS and that high plasma Zn/Cu ratio is associated with the risk of having low HDL and MetS.

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Effect of selenium supplementation on changes in HbA1c: Results from a multiple‐dose, randomized controlled trial

Cited by 21 publications

References 41 publications

Selenium Intake and Glycemic Control in Young Adults With Normal-Weight Obesity Syndrome

Selenium Intake and Glycemic Control in Young Adults With Normal-Weight Obesity Syndrome

Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)

The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data

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