Effect of Selenium Supplementation on Copper Metabolism in Dairy Cows

Buckley, W. T.; Huckin, S. N.; Fisher, L. J.; Eigendorf, Guenter K.

doi:10.4141/cjas86-111

Cited by 9 publications

(1 citation statement)

References 2 publications

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“…The following results were obtained regarding in vivo interactions of both elements: (1) no effect on Cu levels in colon and liver after modulating the Se status from an adequate towards a suboptimal supply. This is in line with previous studies showing stable hepatic Cu levels with increasing Se concentrations [ 46 , 47 ]. However, we observed Cu-induced effects on Cu-responsive proteins such as Mt and Ccs ( Fig.…”

Section: Discussionsupporting

confidence: 93%

Copper interferes with selenoprotein synthesis and activity

et al. 2020

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Selenium and copper are essential trace elements for humans, needed for the biosynthesis of enzymes contributing to redox homeostasis and redox-dependent signaling pathways. Selenium is incorporated as selenocysteine into the active site of redox-relevant selenoproteins including glutathione peroxidases (GPX) and thioredoxin reductases (TXNRD). Copper-dependent enzymes mediate electron transfer and other redox reactions. As selenoprotein expression can be modulated e.g. by H 2 O 2 , we tested the hypothesis that copper status affects selenoprotein expression. To this end, hepatocarcinoma HepG2 cells and mice were exposed to a variable copper and selenium supply in a physiologically relevant concentration range, and transcript and protein expression as well as GPX and TXNRD activities were compared. Copper suppressed selenoprotein mRNA levels of GPX1 and SELENOW, downregulated GPX and TXNRD activities and decreased UGA recoding efficiency in reporter cells. The interfering effects were successfully suppressed by applying the copper chelators bathocuproinedisulfonic acid or tetrathiomolybdate. In mice, a decreased copper supply moderately decreased the copper status and negatively affected hepatic TXNRD activity. We conclude that there is a hitherto unknown interrelationship between copper and selenium status, and that copper negatively affects selenoprotein expression and activity most probably via limiting UGA recoding. This interference may be of physiological relevance during aging, where a particular shift in the selenium to copper ratio has been reported. An increased concentration of copper in face of a downregulated selenoprotein expression may synergize and negatively affect the cellular redox homeostasis contributing to disease processes.

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Section: Discussionsupporting

confidence: 93%

Copper interferes with selenoprotein synthesis and activity

et al. 2020

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Selenium: Geochemical Distribution and Associations with Human Heart and Cancer Death Rates and Longevity in China and the United States

Jackson¹

1988

Selenium

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Selenium: Geochemical distribution and associations with human heart and cancer death rates and longevity in China and the United States

Jackson

1988

Biol Trace Elem Res

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The geochemistry of available soil Se varies enormously in different localities, and the corresponding amounts moving up through crops to food vary accordingly. In a belt extending from northeastern to south central China, the available soil Se was measured by human blood Se levels. Severe deficiency occurred at 8-26 ng/mL; subadequate amounts occurred in large areas with 32-83 ng/mL; adequate amounts of 200-300 ng/mL occurred in large cities; and toxic amounts of 3000-7800 ng/mL occurred in terrace areas where runoff from the uplands evaporated, and in certain other soils. Some heart deaths (Keshan Disease) occurred in children 1 to 10 yr of age in the most deficient areas, but were prevented by 230-900 micrograms/wk Se supplementation. One mg Se/wk was the adult dosage. In Se deficient areas, the life span of adults was lowered severely (35 to 45 yr), with heart muscle damage common at autopsy. Se and Zn deficiencies are apparently associated with stomach cancer. The geochemistry of Se in the USA is also highly variable, blood Se ranging from 100-350 ng/mL. Se data for individuals are limited; however, ischemic heart death correlated inversely with blood Se in 25 cities of 22 states (r = -.70; p less than .01). Counties of Wisconsin and Florida are highly variable in human heart death and cancer death rates, as are the 50 states, suggesting Se geographic variability.

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Effect of Selenium Supplementation on Copper Metabolism in Dairy Cows

Abstract: Eight Holstein cows wbre fed a diet supplemented with selenium at a subtoxic level (2.37 mg kg-' dry matter), or the same diet without selenium supplementation (0.31 mg kg-t dry matter), for 276

Cited by 9 publications

References 2 publications

Copper interferes with selenoprotein synthesis and activity

Copper interferes with selenoprotein synthesis and activity

Selenium: Geochemical Distribution and Associations with Human Heart and Cancer Death Rates and Longevity in China and the United States

Selenium: Geochemical distribution and associations with human heart and cancer death rates and longevity in China and the United States

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