Effect of selenium supplementation on biomarkers of bone turnover

Perri, Giorgia; Hill, Tom R.; Mathers, John C.; Walsh, Jennifer; Gossiel, Fatma; Winther, Kristian Hillert; Frølich, Jacob Stampe; Folkestad, Lars; Cold, Søren; Eastell, Richard

doi:10.1017/s0029665121002330

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…The plasma selenium level was within the optimal level during the follow-up period. The levels of bone turnover markers, measured at 6 months, showed a significant linear decrease in the level of procollagen type 1 N-terminal propeptide (P1NP), although this effect was not apparent at 5 years; no significant effect of selenium supplementation on any other bone formation markers was observed [216]. As P1NP is a marker of osteoblast function [217], the decrease in PINP level indicated a reduction in bone formation.…”

Section: Randomized Clinical Trial Of Selenium Intake: Intervention S...mentioning

confidence: 99%

“…Second, the study population included only postmenopausal women, suggesting that further studies investigating elderly people with selenium deficiency are required [215]. A population with relatively low selenium level was investigated in a single-center, randomized, double-blinded, placebo-controlled, multi-arm, parallel clinical trial (PRE-CISE) in Denmark [216]. The 491 volunteers, aged 60-74 years, were randomly and equally assigned to treatment groups administered 100, 200, or 300 µg selenium per day via selenium-enriched yeast for 5 years (from randomization in 1998-1999) and were followed up for further 10 years.…”

Section: Randomized Clinical Trial Of Selenium Intake: Intervention S...mentioning

confidence: 99%

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The Effects of Selenium on Bone Health: From Element to Therapeutics

et al. 2022

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Osteoporosis, characterized by low bone mass and a disruption of bone microarchitecture, is traditionally treated using drugs or lifestyle modifications. Recently, several preclinical and clinical studies have investigated the effects of selenium on bone health, although the results are controversial. Selenium, an important trace element, is required for selenoprotein synthesis and acts crucially for proper growth and skeletal development. However, the intake of an optimum amount of selenium is critical, as both selenium deficiency and toxicity are hazardous for health. In this review, we have systematically analyzed the existing literature in this field to determine whether dietary or serum selenium concentrations are associated with bone health. In addition, the mode of administration of selenium as a supplement for treating bone disease is important. We have also highlighted the importance of using green-synthesized selenium nanoparticles as therapeutics for bone disease. Novel nanobiotechnology will be a bridgehead for clinical applications of trace elements and natural products.

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Section: Randomized Clinical Trial Of Selenium Intake: Intervention S...mentioning

confidence: 99%

Section: Randomized Clinical Trial Of Selenium Intake: Intervention S...mentioning

confidence: 99%

The Effects of Selenium on Bone Health: From Element to Therapeutics

et al. 2022

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“…No significant effect of selenium supplementation on other bone formation markers was observed. Hence, confirmation of a significant effect of selenium on bone health requires further randomized clinical studies [ 55 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Copper and Selenium Supplementation on the Level of Elements in Rats’ Femurs under Neoplastic Conditions

et al. 2022

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A study was conducted to determine the effect of long-term supplementation with selenium and copper, administered at twice the level used in the standard diet of rats, on the content of selected elements in the femoral bones of healthy rats and rats with implanted LNCaP cancer cells. After an adaptation period, the animals were randomly divided into two experimental groups. The rats in the experimental group were implanted with prostate cancer cells. The rats in the control group were kept in the same conditions as those in the experimental group and fed the same diet, but without implanted cancer cells. The cancer cells (LNCaP) were intraperitoneally implanted in the amount of 1 × 106 (in PBS 0.4 mL) at the age of 90 days. The content of elements in the samples was determined by a quadrupole mass spectrometer with inductively coupled plasma ionization (ICP-MS). In the femoral bones of rats with implanted LNCaP cells, in the case of the standard diet and the copper-enriched diet, there was a marked decreasing trend in the content of the analysed elements relative to the control rats. This may indicate slow osteolysis taking place in the bone tissue. Contrasting results were obtained for the diet enriched with selenium; there was no significant reduction in the level of these elements, and there was even an increase in the concentrations of Fe and K in the bones of rats with implanted LNCaP cells. Particularly, numerous changes in the mineral composition of the bones were generated by enriching the diet with copper. The elements that most often underwent changes (losses) in the bones were cobalt, iron, manganese and molybdenum. The changes observed, most likely induced by the implantation of LNCaP cells, may indicate a disturbance of mineral homeostasis.

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Effect of selenium supplementation on biomarkers of bone turnover

Cited by 2 publications

References 5 publications

The Effects of Selenium on Bone Health: From Element to Therapeutics

The Effects of Selenium on Bone Health: From Element to Therapeutics

Effect of Copper and Selenium Supplementation on the Level of Elements in Rats’ Femurs under Neoplastic Conditions

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