Effect of selenium supplementation on thyroid hormone metabolism in an iodine and selenium deficient population

Contempré, Bernard; Duale, N L; Dumont, Jacques Emile; Ngo, Bebe; Diplock, A. T.; Vanderpas, Jean

doi:10.1111/j.1365-2265.1992.tb02268.x

Cited by 117 publications

(69 citation statements)

References 18 publications

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“…Symptoms of cretinism with myxoedema were observed in the population living within that area, including mental retardation, growth suppression, and impaired puberty. The studies further confirmed that all those conditions had been associated with iodine and selenium deficits on one hand, and with the consumption of large quantities of foods containing goitrogens on the other [44,80]. Negative additive effects, resulting from deficits of either microelement, have also been confirmed by the results of studies on animals [80,81].…”

Section: Prace Poglądowementioning

confidence: 55%

The role of selenium in thyroid gland pathophysiology

Stuss¹,

Michalska-Kasiczak

Sewerynek³

2017

Endokrynologia Polska

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It is now assumed that proper functioning of the thyroid gland (TG), beside iodine, requires also a number of elements, including selenium, iron, zinc, copper, and calcium. In many cases, only an adequate supply of one of these microelements (e.g. iodine) may reveal symptoms resulting from deficits of other microelements (e.g. iron or selenium). Selenium is accounted to the trace elements of key importance for homeostasis of the human system, in particular, for the proper functioning of the immune system and the TG. Results of epidemiological studies have demonstrated that selenium deficit may affect as many as one billion people in many countries all over the world. A proper sequence of particular supplementations is also worth emphasising for the significant correlations among the supplemented microelements. For example, it has been demonstrated that an excessive supplementation of selenium may enhance the effects of iodine deficit in endemic regions, while proper supplementation of selenium in studied animals may alleviate the consequences of iodine excess, preventing destructive-inflammatory lesions in the TG. This paper is a summary of the current knowledge on the role of selenium in the functionality of the TG.

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Section: Prace Poglądowementioning

confidence: 55%

The role of selenium in thyroid gland pathophysiology

Stuss¹,

Michalska-Kasiczak

Sewerynek³

2017

Endokrynologia Polska

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“…In several studies in Iran (12,22,23), Turkey (24,25) and Poland (26), goitrous patients had significant lower Selenium levels than nongoitrous ones. In two other studies, administration of selenium supplementation in children with severe selenium and moderate iodine deficiency and also severe selenium and severe iodine deficiency resulted a significant reduction in serum T4 concentration (27,28). Sufficient selenium activates iodothyronine deiodinases type 1 and type 2 and increase the shift of T4 to T3.…”

Section: J Biol Today's World 2017 Feb; 6 (2): 21-26 Figure 1 Spementioning

confidence: 93%

Assessment of the Selenium Status in Hypothyroid Children from North East of Iran

Khorasani¹,

Mirhafez²,

Niroumand³

2017

J.JBTW

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“…In studies contemporary to the efforts toward purifying DIO1, both animal models and human trials suggested impaired DIO1 activity with low selenium intake (7,8). In healthy African schoolchildren with combined severe iodine and selenium deficiency, selenium supplementation vs placebo led to decreases in serum thyrotropin (TSH) and reverse T 3 (RT 3 ) concentrations, and the authors concluded that selenium intake plays a definite role in thyroid hormone metabolism in humans (8).…”

Section: Introductionmentioning

confidence: 99%

“…In healthy African schoolchildren with combined severe iodine and selenium deficiency, selenium supplementation vs placebo led to decreases in serum thyrotropin (TSH) and reverse T 3 (RT 3 ) concentrations, and the authors concluded that selenium intake plays a definite role in thyroid hormone metabolism in humans (8). Dietary selenium intake varies considerably between populations (9).…”

Section: Introductionmentioning

confidence: 99%

Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population

Winther¹,

Bonnema²,

Cold³

et al. 2015

European Journal of Endocrinology

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Objective: Selenium is present in the active site of proteins important for thyroid hormone synthesis and metabolism. The objective of this study is to investigate the effect of selenium supplementation in different doses on thyroid function, under conditions of suboptimal dietary selenium intake. Design: The Danish PREvention of Cancer by Intervention with SElenium pilot study (DK-PRECISE) is a randomized, doubleblinded, placebo-controlled trial. A total of 491 males and females aged 60-74 years were randomized to 100 mg (nZ124), 200 mg (nZ122), or 300 mg (nZ119) selenium-enriched yeast or matching yeast-based placebo tablets (nZ126). A total of 361 participants, equally distributed across treatment groups, completed the 5-year intervention period. Methods: Plasma samples were analyzed for selenium and serum samples for TSH, free triiodothyronine (FT 3 ), and free thyroxine (FT 4 ) at baseline, and after 6 months, and 5 years of supplementation. Results: Plasma selenium concentrations increased significantly and dose-dependently in treatment groups receiving selenium (P!0.001). Serum TSH and FT 4 concentrations decreased significantly and dose-dependently by 0.066 mIU/l (PZ0.010) and 0.11 pmol/l (PZ0.015), respectively, per 100 mg/day increase, with insignificant differences between 6 months and 5 years. No significant effects were found for FT 3 and FT 3 :FT 4 ratio. Conclusions: In euthyroid subjects, selenium supplementation minutely and dose-dependently affects thyroid function, when compared with placebo, by decreasing serum TSH and FT 4 concentrations. Based on these findings, selenium supplementation is not warranted under conditions of marginal selenium deficiency. However, a role for selenium supplementation in the treatment of autoimmune thyroid diseases is still unresolved.

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Effect of selenium supplementation on thyroid hormone metabolism in an iodine and selenium deficient population

Cited by 117 publications

References 18 publications

The role of selenium in thyroid gland pathophysiology

The role of selenium in thyroid gland pathophysiology

Assessment of the Selenium Status in Hypothyroid Children from North East of Iran

Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population

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