Effect of N‐acetylcysteine supplementation on oxidative stress status and alveolar inflammation in people exposed to asbestos: A double‐blind, randomized clinical trial

Abstract

No evidence was found that NAC supplementation replenishes total combined thiols in the blood of healthy subjects with a history of asbestos exposure. There was also no evidence of reduced indicators of inflammation or oxidative stress. Further studies should determine the conditions required to increase levels of total anti-oxidant capacity in the blood and in the lungs of subjects with either asbestos-related diseases or subclinical lung inflammation.

The Potential Use of Metabolic Cofactors in Treatment of NAFLD

“…The typical daily dose of NAC reported was 5.8 g/day; with a range between 1.2 and 20.0 g/day [49]. The effect of NAC supplementation on oxidative stress status and alveolar inflammation was analyzed in a double-blind, randomized clinical trial using a dose of 1800 mg/day for 4 months in people exposed to asbestos [50]. NAC was administered in oral doses of 6000–8000 mg daily for several months in HIV-infected patients.…”

“…The effect of NAC supplementation on oxidative stress status and alveolar inflammation was analyzed in a double-blind, randomized clinical trial using a dose of 1800 mg/day for 4 months in people exposed to asbestos [50].…”

The exposure to pollutants of the auto repair workers: Monitoring their oxidative stress

“…The main pollutants, or risk factors, that involved the workers in the car repair section are essentially fine dust, lead, polycyclic aromatic containing gases, the CO, and mineral oils. For each pollutant, the biological damage and the ways for monitoring are reported in literature, and in some cases also an estimation of the oxidative stress induced individually,[ 10 11 12 13 ]). In our study, it cannot be affirmed which one specifically has raised in a statistically significant way the values of salivary MDA among workers compared to the control group; this consideration may be even more important, if considered the synergistic contribution that certainly can have smoking and age., with the other risk factors.…”