Effect of <scp>d</scp>-β-hydroxybutyrate-(<i>R</i>)-1,3 butanediol on plasma levels of asprosin and leptin: results from a randomised controlled trial

Charles, Sanjali; Liu, Yutong; Kimita, Wandia; Ko, Jung Hwa; Bharmal, Sakina H; Petrov, Maxim S.

doi:10.1039/d2fo02405e

Cited by 3 publications

(2 citation statements)

References 46 publications

(71 reference statements)

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“…That study also reported no changes in the circulating levels of ghrelin and leptin [ 27 ]. It is pertinent to note here that another CETUS study also found no significant effect of acute ketone supplementation on the circulating levels of leptin [ 28 ]. The utility that exogenous ketone supplements may have during weight loss interventions is likely based on their ability to reduce stress markers during exercise and prolong the period of intense activity rather than modulate appetite [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Acute Nutritional Ketosis on Circulating Levels of Growth Differentiation Factor 15: Findings from a Cross-Over Randomised Controlled Trial

Charles,

Liu,

Bharmal

et al. 2024

Biomolecules

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Exogenous supplementation with ketone beverages has been shown to reduce plasma glucose levels during acute nutritional ketosis. It remains to be investigated whether growth differentiation factor 15 (GDF-15)—an anorexigenic hormone—is involved in this process. The aim was to investigate the effect of a ketone ester beverage delivering β-hydroxybutyrate (KEβHB) on plasma levels of GDF-15, as well as assess the influence of eating behaviour on it. The study was a randomised controlled trial (registered at clinicaltrials.gov as NCT03889210). Individuals were given a KEβHB beverage or placebo in a cross-over fashion. Blood samples were collected at baseline, 30, 60, 90, 120, and 150 min after ingestion. Eating behaviour was assessed using the three-factor eating questionnaire. GDF-15 levels were not significantly different (p = 0.503) after the KEβHB beverage compared with the placebo. This finding remained consistent across the cognitive restraint, emotional eating, and uncontrolled eating domains. Changes in the anorexigenic hormone GDF-15, irrespective of eating behaviour, do not appear to play a major role in the glucose-lowering effect of exogenous ketones.

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Section: Discussionmentioning

confidence: 99%

Effect of Acute Nutritional Ketosis on Circulating Levels of Growth Differentiation Factor 15: Findings from a Cross-Over Randomised Controlled Trial

Charles,

Liu,

Bharmal

et al. 2024

Biomolecules

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“…Upon ingestion of food, the gastrointestinal tract secrets several different hormones, such as the incretin hormones and oxyntomodulin [89,90]. These gut hormones are secreted to regulate satiety, carbohydrate absorption, gastric emptying, and glucose metabolism [91,92]. Incretin hormones, such as glucose-dependent insulinotropic polypeptide (GIP) and glucagonlike peptide 1 (GLP-1), are responsible for augmenting the insulin-secretory response initiated by hyperglycaemia [93].…”

Section: Interplay With Gut Hormonesmentioning

confidence: 99%

Dietary Fibre for the Prevention of Post-Pancreatitis Diabetes Mellitus: A Review of the Literature and Future Research Directions

Li,

Petrov

2024

Nutrients

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Post-pancreatitis diabetes mellitus—the most common sequela of pancreatitis—leads to poorer glycaemic control compared with type 2 diabetes. Because post-pancreatitis diabetes mellitus is an exemplar of secondary diabetes (with a clear underlying cause), much post-pancreatitis diabetes mellitus is preventable or treatable early. Earlier literature established the important role of dietary fibre in reducing plasma glucose in individuals with type 2 diabetes. The present review benchmarks available evidence on the role of habitual dietary fibre intake in pancreatitis and post-pancreatitis diabetes mellitus. It also paves the way for future research on the use of dietary fibre in the post-pancreatitis setting.

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Response to lowering plasma glucose is characterised by decreased oxyntomodulin: Results from a randomised controlled trial

Liu,

Kimita,

Bharmal

et al. 2024

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Effect of d-β-hydroxybutyrate-(R)-1,3 butanediol on plasma levels of asprosin and leptin: results from a randomised controlled trial

Abstract: Background: D-β-hydroxybutyrate-(R)-1,3 butanediol – a non-racemic ketone monoester for ingestion – has emerged as an effective way to achieve acute nutritional ketosis. Whether white adipose tissue plays a role in...

Cited by 3 publications

References 46 publications

Effect of Acute Nutritional Ketosis on Circulating Levels of Growth Differentiation Factor 15: Findings from a Cross-Over Randomised Controlled Trial

Effect of Acute Nutritional Ketosis on Circulating Levels of Growth Differentiation Factor 15: Findings from a Cross-Over Randomised Controlled Trial

Dietary Fibre for the Prevention of Post-Pancreatitis Diabetes Mellitus: A Review of the Literature and Future Research Directions

Response to lowering plasma glucose is characterised by decreased oxyntomodulin: Results from a randomised controlled trial

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