Effect of Sclerocarya birrea (Anacardiaceae) stem bark methylene chloride/methanol extract on streptozotocin-diabetic rats

Dimo, Théophile; Rakotonirina, S.V.; Tan, Paul V.; Azay, Jacqueline; Dongo, Étienne; Kamtchouing, Pièrre; Cros, Gérard

doi:10.1016/j.jep.2006.10.020

Cited by 73 publications

(70 citation statements)

References 14 publications

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“…For example, higher concentration of Iron in the leaves of Sterculia setigera might be due to its biological character which has broad leaves and absorbed more Iron from the surrounding environment, the differences between the concentrations of heavy metal accumulated and distributed in each part of the plant, depends on the bioavailability of the heavy metal in the soil. This work is in agreement with the previous work of Ye [22] who reported that heavy metal concentration in plants are in descending other Iron, Zinc Manganese, Lead and Cadmium, however, despite the high concentration are still within the permissible limit FAO/WHO [23]. Figure 4 showed the results of concentration of heavy metal in Jalingo.…”

Section: Resultssupporting

confidence: 91%

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Evaluation of Heavy Metals Concentration in Selected Medicinal Plants (Sterculia setigera Del. and Sclerocarya birrea (A. rich.) Hochst) Collected from Bwabul Spring, Bambuka and Jalingo Low-lands, Taraba State

Isa¹,

Louis²,

Mijinyawa³

et al. 2017

J Environ Anal Chem

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Analytical study was conducted on some selected medicinal plants (Sterculia setigera Del. and Sclerocarya birrea (A. rich.) Hochst) collected from Bwabul Spring, Bambuka, and Jalingo Low-Lands in order to determine the presence and levels of some selected heavy metals (Cd, Mn, Fe Pb and Zn) and also to compare the concentrations of these metals from the two locations. Results obtained from this study revealed that the concentration of elements Cadmium, Iron and Lead (0.03 ± 0.06, 4.84 ± 0.08 and 0.06 ± 0.02) mg/kg from Bwabul were lower compared to those from Jalingo Low-lands (0.21 ± 0.07, 6.03 ± 0.05 and 0.36 ± 0.02) mg/kg. On the other hand, the concentration of Zinc and Manganese (5.69 ± 0.08 and 1.87 ± 0.10) mg/kg are higher from Bwabul as compared to Jalingo Low-lands (4.29 ± 0.10 and 1.45 ± 0.00) mg/kg. However, despite the high concentrations of these elements from the two locations, they were found to be within the permissible limit set by WHO/FAO as at the time of determination.

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Section: Resultssupporting

confidence: 91%

“…This could be regarded as the effect of climatic condition as well as the nature of the element on it efficiency. However, despite the high concentration of these elements are still within the permissible limit of FAO/WHO [23].…”

Section: Resultsmentioning

confidence: 96%

Evaluation of Heavy Metals Concentration in Selected Medicinal Plants (Sterculia setigera Del. and Sclerocarya birrea (A. rich.) Hochst) Collected from Bwabul Spring, Bambuka and Jalingo Low-lands, Taraba State

Isa¹,

Louis²,

Mijinyawa³

et al. 2017

J Environ Anal Chem

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“…birrea stem-bark extracts have been shown to exert hypoglycaemic effects in animal models. In rats with streptozotocin-induced diabetes, acute administration of S. birrea stem-bark extract reduces blood glucose levels (Ojewole 2003, Dimo et al 2007. Chronically, the efficacy of S. birrea stem-bark extract administered for 5 weeks was shown to be similar to metformin treatment with regards to lowering of glycaemia (Gondwe et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…This process is referred to as metabolism-secretion coupling, since glucose oxidation promotes ATP generation necessary for the triggering of exocytosis signals. Elevation of plasma insulin was reported in stem-bark-treated diabetic rats (Dimo et al 2007). Accordingly, it was of importance to investigate putative direct effects of S. birrea on insulin-secreting cells.…”

Section: Introductionmentioning

confidence: 99%

Sclerocarya birrea (Anacardiaceae) stem-bark extract corrects glycaemia in diabetic rats and acts on β-cells by enhancing glucose-stimulated insulin secretion

Ndifossap¹,

Frigerio²,

Casimir³

et al. 2010

Journal of Endocrinology

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Sclerocarya birrea is a plant widely used as traditional medication for the treatment of diabetes in sub-Saharan regions. However, the mechanism of action is unknown and only hypoglycaemic effects of S. birrea extract (SBE) in diabetic rats have been reported to date. Here, we tested aqueous extracts of S. birrea on insulin-secreting INS-1E cells and isolated rat islets. Following 24 h of treatment at 5 mg/ml, the extract markedly potentiated glucose-stimulated insulin secretion. Neither basal insulin release nor non-nutrient stimulation was affected. The potentiation of the secretory response at stimulatory glucose appeared after 12 h of treatment. No acute effects were observed and, at the effective concentration, SBE was safe regarding cell integrity and differentiation. The mechanism of action of the SBE was related to glucose metabolism as both ATP generation and glucose oxidation were enhanced following the 24-h treatment. In streptozotocin-induced diabetic rats, SBE administration corrected glycaemia and restored plasma insulin levels after 2 weeks of treatment. These data show direct action of S. birrea on insulin-secreting cells and favour further delineation for use of the plant in the management of diabetes.

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“…Acarbose and miglitol are examples of enzyme inhibitors that are already in clinical use. Some medicinal plants have also been reported to inhibit the activity of α-amylase and α-glucosidase (Dimo et al, 2007). Examples of such plants are Musa paradisiacal (Shodehinde and Oboh, 2012), Tourneforia hartwegiana (Oritz et al, 2007) and Allium spp.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of leaf extract of <i>Newbouldia laevis</i> on the metabolic activities of alpha-glucosidase and alpha-amylase

Kolawole

Akanji

2013

Bangladesh J Pharmacol

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In this study, the effect of ethanol extract of the leaves of Newbouldia laevis on the activity of α-amylase and α-glucosidase was investigated. Inhibitory effect of N. laevis extract on α-glucosidase was tested in vitro using baker's yeast α-glucosidase and rat intestinal α-glucosidase while α-amylase inhibitory effect was assayed using rat pancreatic α-amylase. α-Glucosidase inhibitory effect of the extract was also tested in vivo in diabetic and non-diabetic rats. N. laevis extract exhibited good α-glucosidase inhibitory activity in vitro with IC50 values of 2.2 µg/mL and 43.5 µg/mL for baker's yeast and rat intestinal α-glucosidase respectively. The extract also inhibited rat pancreatic α-amylase activity with IC50 value of 58.7 µg/mL. In both diabetic and non-diabetic rats, N. laevis extract caused a significant reduction in postprandial blood glucose level after oral sucrose load. The results of this study indicate that N. laevis extract exerts its glucose-lowering effect through inhibition of α-glucosidase and α-amylase. Article Info

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Effect of Sclerocarya birrea (Anacardiaceae) stem bark methylene chloride/methanol extract on streptozotocin-diabetic rats

Cited by 73 publications

References 14 publications

Evaluation of Heavy Metals Concentration in Selected Medicinal Plants (Sterculia setigera Del. and Sclerocarya birrea (A. rich.) Hochst) Collected from Bwabul Spring, Bambuka and Jalingo Low-lands, Taraba State

Evaluation of Heavy Metals Concentration in Selected Medicinal Plants (Sterculia setigera Del. and Sclerocarya birrea (A. rich.) Hochst) Collected from Bwabul Spring, Bambuka and Jalingo Low-lands, Taraba State

Sclerocarya birrea (Anacardiaceae) stem-bark extract corrects glycaemia in diabetic rats and acts on β-cells by enhancing glucose-stimulated insulin secretion

Inhibitory effect of leaf extract of <i>Newbouldia laevis</i> on the metabolic activities of alpha-glucosidase and alpha-amylase

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