Effect of Schwann cell transplantation combined with electroacupuncture on axonal regeneration and remyelination in rats with spinal cord injury

Tan, Cheng-Fang; Yang, Cheng; Liu, Hui; Tang, Cheng‐Lin; Huang, Si-Qin

doi:10.1002/ar.24721

Cited by 8 publications

(7 citation statements)

References 62 publications

(75 reference statements)

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“…66 Cell-based regeneration studies on SCI include using cell types of Schwann's cells, neural stem cells (NSC), mesenchymal stem cells (MSCs), or oligodendrocyte precursor cells (OPCs) 8 showing the different mechanisms in SCI repair. For example, in a study conducted by Tan et al, 66 Schwann cell transplantation aided with electroacupuncture was targeted to enhance axonal remyelination. 66 The study showed successful axon remyelination in the rat model with SCI.…”

Section: The Potential Of Regenerative Therapymentioning

confidence: 99%

“…For example, in a study conducted by Tan et al, 66 Schwann cell transplantation aided with electroacupuncture was targeted to enhance axonal remyelination. 66 The study showed successful axon remyelination in the rat model with SCI. This indicates the ability of the Schwann cell to regenerate the demyelinated axon which potentially reverses the neurological defect after SCI.…”

Section: The Potential Of Regenerative Therapymentioning

confidence: 99%

“…Neuroregeneration therapy has been widely studied including using cell-based therapies, ,,,− electrical stimulation, ,,,− and biomaterials ,,,,,− for their potential in repairing SCI. Cell-based therapies which were originally derived from stem cell transplantation studies demonstrated the promotion of axon growth and myelination.…”

Section: Introductionmentioning

confidence: 99%

“…This has motivated the expansion of studies in this area. Its main strategy is to overcome the regeneration inhibitors after SCI by forming a functional relay and providing a regeneration signal for the damaged neurons . Cell-based regeneration studies on SCI include using cell types of Schwann’s cells, neural stem cells (NSC), mesenchymal stem cells (MSCs), or oligodendrocyte precursor cells (OPCs) showing the different mechanisms in SCI repair.…”

Section: Introductionmentioning

confidence: 99%

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Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

Shahemi

Mahat

Asri

et al. 2023

ACS Biomater. Sci. Eng.

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Spinal cord injury (SCI) causes severe motor or sensory damage that leads to long-term disabilities due to disruption of electrical conduction in neuronal pathways. Despite current clinical therapies being used to limit the propagation of cell or tissue damage, the need for neuroregenerative therapies remains. Conductive hydrogels have been considered a promising neuroregenerative therapy due to their ability to provide a pro-regenerative microenvironment and flexible structure, which conforms to a complex SCI lesion. Furthermore, their conductivity can be utilized for noninvasive electrical signaling in dictating neuronal cell behavior. However, the ability of hydrogels to guide directional axon growth to reach the distal end for complete nerve reconnection remains a critical challenge. In this Review, we highlight recent advances in conductive hydrogels, including the incorporation of conductive materials, fabrication techniques, and cross-linking interactions. We also discuss important characteristics for designing conductive hydrogels for directional growth and regenerative therapy. We propose insights into electrical conductivity properties in a hydrogel that could be implemented as guidance for directional cell growth for SCI applications. Specifically, we highlight the practical implications of recent findings in the field, including the potential for conductive hydrogels to be used in clinical applications. We conclude that conductive hydrogels are a promising neuroregenerative therapy for SCI and that further research is needed to optimize their design and application.

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Section: The Potential Of Regenerative Therapymentioning

confidence: 99%

Section: The Potential Of Regenerative Therapymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

Shahemi

Mahat

Asri

et al. 2023

ACS Biomater. Sci. Eng.

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“…EA regulation of ApoE and Nrf2 to inhibit inflammation and oxidative stress in SCI has been also reported [ 15 ]. EA stimulation was reported to regulate the function of SCs, which favors axonal recovery post-SCI [ 16 ]. Through regulating Notch signaling pathway, EA was found to promote the recovery following SCI in rats [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture-Regulated miR-34a-3p/PDCD6 Axis Promotes Post-Spinal Cord Injury Recovery in Both In Vitro and In Vivo Settings

et al. 2022

Journal of Immunology Research

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Electroacupuncture (EA) could enhance neuroregeneration and posttraumatic conditions; however, the underlying regulatory mechanisms remain ambiguous. PDCD6 (programmed cell death 6) is an established proapoptotic regulator which is responsible for motoneuronal death. However, its potential regulatory role in post-spinal cord injury (SCI) regeneration has remained largely unknown. Further investigations are warranted to clarify the involvement of PDCD6 post-SCI recovery and the underlying mechanisms. In our study, based on bioinformatics prediction, we found that miR-34a-3p might be an upstream regulator miRNA for PDCD6, which was subsequently validated through combined utilization of the qRT-PCR, western blot, and dual-luciferase reporter system. Our in vitro results showed that miR-34a-3p might promote the in vitro differentiation of neural stem cell (NSC) through suppressing PDCD6 and regulating other important neural markers such as fibroblast growth factor receptor 1 (FGFR1), MAP1/2 (MAP kinase kinases 1/2), myelin basic protein (MBP), βIII-tubulin Class III β-tubulin (βIII tubulin), and glial fibrillary acidic protein (GFAP). Notably, in the post-SCI rat model, exogenous miR-34a-3p agomir obviously inhibited the expression of PDCD6 at the protein level and promoted neuronal proliferation, motoneurons regeneration, and axonal myelination. The restorations at cellular level might contribute to the improved hindlimbs functions of post-SCI rats, which was manifested by the Basso-Beattie-Bresnahan (BBB) locomotor test. The impact of miR-34a-3p was further promoted by EA treatment in vivo. Conclusively, this paper argues that a miR-34a-3p/PDCD6 axis might be a candidate therapeutic target for treating SCI and that the therapeutic effect of EA is driven through this pathway.

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Comparative efficacy and safety of acupuncture and Western medicine for poststroke thalamic pain

Yang

et al. 2022

The Anatomical Record

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Poststroke thalamic pain (PSTP) is one of the most common sequelae following stroke. Analgesics, antidepressants, anticonvulsants, and surgical treatment are conventional treatment methods of PSTP, but these methods have limited efficacy, cost more, and cause a likelihood of adverse reactions. Clinical studies have shown that acupuncture has a significant analgesic effect on PSTP without obvious side effects. But, there is a lack of high‐quality evidence concerning its effectiveness and safety to support its use. Therefore, this study aimed to evaluate the clinical efficacy and safety of acupuncture versus Western medicine for the treatment of PSTP to provide evidence to support clinical PSTP treatment. Searches were conducted to identify randomized controlled trials investigating the use of acupuncture for PSTP across six databases, including PubMed, the Cochrane Library, EMBASE, the China National Knowledge Infrastructure, Wan Fang Database, and the Chinese Scientific Journal Database VIP. RevMan 5.3 software was used for the meta‐analysis. The results showed that compared with Western medicine, acupuncture had a higher total effective rate for the treatment of PSTP, reduced visual analog scale scores, increased beta‐endorphin content, and decreased incidence of adverse reactions. However, the sample sizes of the included studies were insufficient, and the quality of the articles was relatively poor. In future studies, the clinical study design should be standardized and the sample size should be expanded to validate these results.

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Effect of Schwann cell transplantation combined with electroacupuncture on axonal regeneration and remyelination in rats with spinal cord injury

Cited by 8 publications

References 62 publications

Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

Electroacupuncture-Regulated miR-34a-3p/PDCD6 Axis Promotes Post-Spinal Cord Injury Recovery in Both In Vitro and In Vivo Settings

Comparative efficacy and safety of acupuncture and Western medicine for poststroke thalamic pain

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