Effect of SCH 23390 on (±)-3,4-methylenedioxymethamphetamine hyperactivity and self-administration in rats

Daniela, Evangelene Joy Kia; Brennan, Katie; Gittings, Dave; Hely, Lincoln S.; Schenk, Susan

doi:10.1016/j.pbb.2004.01.008

Cited by 104 publications

(125 citation statements)

References 61 publications

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“…Since CPP is believed to be a measure of appetitive behavior where the animal associates contextual cues with either a positive or negative feeling produced by the drug, these results provide direct evidence of the rewarding properties of MDMA in rats. A rewarding effect of MDMA has also been shown in the self-stimulation paradigm in rats (Hubner et al, 1988), where MDMA lowers the reward threshold of electrical stimulation, and in the drug self-administration test in rats (Schenk et al, 2003;Daniela et al, 2004) and baboons (Lamb and Griffiths, 1987). The locomotor hyperactivity observed after MDMA injection is also consistent with this drug exerting a positive rewarding effect (Gold and Koob, 1988;Gold et al, 1989a).…”

mentioning

confidence: 62%

Elevation of Ambient Room Temperature has Differential Effects on MDMA-Induced 5-HT and Dopamine Release in Striatum and Nucleus Accumbens of Rats

O’Shea

Escobedo

Orío

et al. 2005

Neuropsychopharmacol

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3,4-Methylenedioxymethamphetamine (MDMA) produces acute dopamine and 5-HT release in rat brain and a hyperthermic response, which is dependent on the ambient room temperature in which the animal is housed. We examined the effect of ambient room temperature (20 and 301C) on MDMA-induced dopamine and 5-HT efflux in the striatum and shell of nucleus accumbens (NAc) of freely moving rats by using microdialysis. Locomotor activity and rectal temperature were also evaluated. In the NAc, MDMA (2.5 or 5 mg/kg, i.p.) produced a substantial increase in extracellular dopamine, which was more marked at 301C. 5-HT release was also increased by MDMA given at 301C. In contrast, MDMA-induced extracellular dopamine and 5-HT increases in the striatum were unaffected by ambient temperature. At 201C room temperature, MDMA did not modify the rectal temperature but at 301C it produced a rapid and sustained hyperthermia. MDMA at 201C room temperature produced a two-fold increase in activity compared with salinetreated controls. The MDMA-induced increase in locomotor activity was more marked at 301C due to a decrease in the activity of the saline-treated controls at this high ambient temperature. These results show that high ambient temperature enhances MDMA-induced locomotor activity and monoamine release in the shell of NAc, a region involved in the incentive motivational properties of drugs of abuse, and suggest that the rewarding effects of MDMA may be more pronounced at high ambient temperature.

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mentioning

confidence: 62%

Elevation of Ambient Room Temperature has Differential Effects on MDMA-Induced 5-HT and Dopamine Release in Striatum and Nucleus Accumbens of Rats

O’Shea

Escobedo

Orío

et al. 2005

Neuropsychopharmacol

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“…This elevation of NAcc(sh) dopamine is widely accepted as the basis for drug-induced reward (Wise and Bozarth, 1984;Hoebel, 1985;Koob and Weiss, 1992;Carlezon and Wise, 1996;Everitt et al, 1999;Di Chiara and Imperato, 1988). Conversely, disruption of dopamine transmission attenuates the rewarding effects of MDMA in rats trained to self-administer MDMA (Daniela et al, 2004). Therefore, the enhanced MDMA-induced dopamine efflux observed after previous exposure to MDMA + chronic stress could reflect an increase in the rewarding and addictive properties of MDMA.…”

Section: Discussionmentioning

confidence: 99%

Prior Exposure to Chronic Stress and MDMA Potentiates Mesoaccumbens Dopamine Release Mediated by the 5-HT1B Receptor

Amato

Bankson

Yamamoto

2006

Neuropsychopharmacol

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( + ) 3,4,-Methylenedioxymethamphetamine (MDMA) is an abused drug that acutely releases serotonin (5-HT) and dopamine (DA) but produces long-term damage to 5-HT terminals. MDMA-induced DA release has been shown to be dampened by 5-HT. Although stress also activates the mesolimbic DA pathway, it is unknown if chronic stress after exposure to neurotoxic doses of MDMA will augment MDMA-induced DA release in the nucleus accumbens shell (NAcc(sh)). Rats were pretreated with MDMA (10 mg/kg Â 4, intraperitoneal (i.p.)). After 7 days, rats were subjected to 10 days of chronic unpredictable stress. DA release in the NAcc(sh) and 5-HT in the ventral tegmental area (VTA) were measured after a challenge injection of MDMA (5 mg/kg, i.p.). The combination of pretreatment with MDMA + stress decreased basal concentrations of 5-HT in the VTA and DA in the NAcc(sh) and enhanced MDMAstimulated DA release in the NAcc(sh). Pretreatment with MDMA or stress alone blunted MDMA-induced 5-HT release in the VTA. The augmentation of MDMA-induced DA release in rats pretreated with MDMA + chronic stress was attenuated by perfusion of the 5-HT 1B antagonist, GR127935 into the VTA before the MDMA challenge injection. These results suggest that prior exposure to both MDMA and stress can produce a long-term augmentation in mesolimbic DA transmission and enhanced drug abuse vulnerability that is mediated, in part, by the 5-HT 1B receptor in the VTA. Neuropsychopharmacology (2007) 32, 946-954.

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“…The outcomes of this study included very low inactive lever responding, and dose-dependent responding for MDMA. In a subsequent report, Schenk and colleagues reported on the role of DA in MDMA self-administration and hyperactivity (Daniela et al 2004). In this report, the training dose of MDMA was 1.0 mg/kg and experiments were conducted daily during 2-hr tests sessions.…”

Section: Schenk and Colleaguesmentioning

confidence: 99%

Relevance of rodent models of intravenous MDMA self-administration to human MDMA consumption patterns

2006

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Rationale: Despite decades of research specifying harmful effects produced by 3,4-methylenedioxymethamphetamine (MDMA; a principal component of 'ecstasy' pills), young people (and adults) continue to use it.In an attempt to model human MDMA consumption patterns, preclinical investigators have sought to establish reliable patterns of intravenous MDMA self-administration in rodents. Objective: The objective of this report is to offer a critical review of published data (including our own novel findings) that reveal MDMA self-administration in rodents. Results: The data indicate that MDMA serves as a reinforcer in rodents, though the responses are not similar to those previously reported for psychostimulants (i.e., cocaine). Important differences between rodent models and human use patterns include frequency of dosing and dosage exposure, routes of administration, tolerance that develops to MDMA after repeated exposure, polydrug use in humans but not by rodents, limits on the repertoire of behaviors that can be exhibited by rodents undergoing IV self-administration procedures, and the question of neurotoxicity as it relates to models of self-administration. Conclusions: While MDMA is not as potent a reinforcer as other drugs of abuse, the fact remains that young people and adults continue to use the drug, and therefore, additional research is needed to determine why drugs with low reinforcing effects continue to be abused.

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Effect of SCH 23390 on (±)-3,4-methylenedioxymethamphetamine hyperactivity and self-administration in rats

Cited by 104 publications

References 61 publications

Elevation of Ambient Room Temperature has Differential Effects on MDMA-Induced 5-HT and Dopamine Release in Striatum and Nucleus Accumbens of Rats

Elevation of Ambient Room Temperature has Differential Effects on MDMA-Induced 5-HT and Dopamine Release in Striatum and Nucleus Accumbens of Rats

Prior Exposure to Chronic Stress and MDMA Potentiates Mesoaccumbens Dopamine Release Mediated by the 5-HT1B Receptor

Relevance of rodent models of intravenous MDMA self-administration to human MDMA consumption patterns

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