Effect of scaling and root planing on blood counts in patients with chronic generalized periodontitis

Kalsi, Devinder Singh; Sood, Anchal; Mundi, Simran; Sharma, Vikrant

doi:10.4103/ijds.ijds_1_17

Cited by 5 publications

(5 citation statements)

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“…Significant variations in the neutrophils were seen between the various groups and subgroups of periodontitis. These results coincide with previous studies (1)(2)(12)(13)(14) . Periods of bacteremia in periodontitis or lipopolysaccharide leakage to the systemic circulation result in greater amounts of neutrophil discharge since they are the first line of defense in the innate immune system (15) .…”

Section: Resultssupporting

confidence: 93%

“…Periods of bacteremia in periodontitis or lipopolysaccharide leakage to the systemic circulation result in greater amounts of neutrophil discharge since they are the first line of defense in the innate immune system (15) . According to other investigations (2,3,12,14,16,17) , lymphocytes demonstrated considerable variations between groups and periodontitis subgroups, but disagrees with other studies (4,13) . When the severity of periodontal disease has been increased, there were increased numbers of neutrophils in the connective tissue and the appearance of macrophages, lymphocytes, plasma cells and mast cells.…”

Section: Resultscontrasting

confidence: 58%

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Evaluation of leukocytes cells types counts in blood from patients with different severities of periodontal diseases

2023

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Background: Periodontal diseases are inflammatory disorders caused by the accumulation of oral biofilm and the host response to this accumulation which characterized by exaggerated leukocytes and neutrophils attraction to the sites of inflammation by chemoattractants which are a very important part of the pathogenesis of periodontal diseases. This study aimed to determine and compare the clinical periodontal parameters and the leukocyte cell types in the peripheral blood between patients with gingivitis and periodontitis with different severities compared to healthy controls. Materials and methods: This study included 150 male subjects aged between 35-50 years. They were divided into three groups: gingivitis group (n=30), periodontitis patients (n=90) which subdivided into Mild =30 patients, Moderate =30 patients, Severe =30 patients and a control group (n=30) with clinically healthy periodontium. Clinical periodontal parameters were recorded ((plaque index (PLI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL)). Blood samples were collected then an automated blood analyzer evaluated leukocyte cell types. Results: Significant differences in The counts of neutrophils and lymphocytes exhibited significant differences among the study groups and subgroups. On contrary, differences in monocytes, eosinophils, and basophils counts were not significant. Additionally, severity of periosontitis was significantly correlated with the mean counts of the various leukocyte cell types; however, clinical periodontal characteristics did not show such correlation with these inflammatory cells. Conclusion: This study demonstrated that periodontal disease with different severities is associated with possible episodes of bacteremia that originate from periodontal lesions which mediate inflammatory conditions that in turn causing changes in the systemic markers especially leukocytes cells types.

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Section: Resultssupporting

confidence: 93%

Section: Resultscontrasting

confidence: 58%

Evaluation of leukocytes cells types counts in blood from patients with different severities of periodontal diseases

2023

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“…ESR is another inflammatory marker and is less specific and sensitive to inflammation than CRP. However, various studies depicted that subjects with chronic periodontitis have higher levels of ESR compared to healthy subjects, as reported by Kalsi et al in 2017 [ 15 ] and Merchant in 2002 [ 16 ], and a significant decrease is reported after periodontal therapy. The results of the present study show an increase in PISA value with increased ESR in subjects with periodontitis.…”

Section: Discussionmentioning

confidence: 93%

Assessing the Correlation of Periodontal Inflamed Surface Area (PISA) With Systemic Inflammatory Markers

Kumari,

Banerjee,

Verma

et al. 2024

Cureus

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Background Periodontitis has a vital role in eliciting a cross-reactivity or systemic inflammatory response, making periodontal inflamed surface area (PISA) a primary contributor to the inflammatory burden posed by periodontitis. PISA helps in the quantification of the amount of inflamed periodontal tissue. However, the existing literature data concerning PISA as an indicator of inflammatory burden are scarce, with limited research on the relationship between systemic inflammatory markers and PISA. Aim The present clinic-hematological cross-sectional study aimed to correlate PISA with systemic inflammatory markers. The study also aimed to assess serum concentrations of inflammatory markers such as erythrocyte sedimentation rates (ESR), C-reactive protein (CRP), and peripheral blood markers such as neutrophils and monocytes and to correlate these markers with PISA. Methods The study assessed 62 subjects, who were divided into two groups of 31 subjects, each following bleeding on probing (BOP) criteria. Group I consisted of subjects with generalized chronic gingivitis, and Group II included subjects with generalized chronic periodontitis. In two groups, BOP, probing pocket depth, clinical attachment level, and gingival recession were assessed along with PISA by a custom-made R function derived from a pre-existing, freely available MS Excel spreadsheet (Microsoft Corporation, Redmond, Washington). The results of the assessment were then compared. Results A statistically highly significant positive correlation was seen in PISA and CRP with a correlation coefficient of 0.4875 and p-value of 0.000059. A similar statistically significant positive correlation was seen in ESR and PISA with a correlation coefficient of 0.4089 and p-value of 0.000968. A statistically non-significant correlation was seen in neutrophils and PISA with p=0.576018. However, a moderate and positive statistically significant association was seen in monocyte and PISA with a correlation coefficient of 0.3258 and p-value of 0.009956. Conclusions The present study concludes that most of the common systemic inflammatory markers have a positive correlation with PISA. However, more studies are required to establish this correlation.

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“…A total of 70 volunteers were recruited from patients visiting the hospital for treatment of periodontitis. The volunteers were interviewed and examined for eligibility for inclusion in the study in case they met the following selection criteria: diagnosed with chronic periodontitis with radiographic bone loss and bleeding on probing; had at least 20 natural teeth with at least two probing pockets with a depth of >3 mm; had not undergone periodontal treatments within the previous 6 months; had not used systemic antimicrobials within 6 weeks before the study; and had no allergy to egg or to any of the ingredients of the study products. Participants were excluded if they were diagnosed as having systemic diseases or could not follow the protocol of the study.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of lozenges containing egg yolk antibody against Porphyromonas gingivalis gingipains as an adjunct to conventional non‐surgical therapy in periodontitis patients: A randomized controlled clinical trial

Nguyen

Tran

et al. 2018

Journal of Periodontology

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Effect of scaling and root planing on blood counts in patients with chronic generalized periodontitis

Cited by 5 publications

References 1 publication

Evaluation of leukocytes cells types counts in blood from patients with different severities of periodontal diseases

Evaluation of leukocytes cells types counts in blood from patients with different severities of periodontal diseases

Assessing the Correlation of Periodontal Inflamed Surface Area (PISA) With Systemic Inflammatory Markers

Evaluation of lozenges containing egg yolk antibody against Porphyromonas gingivalis gingipains as an adjunct to conventional non‐surgical therapy in periodontitis patients: A randomized controlled clinical trial

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