EFFECT OF SAUDI ARABIAN Capparis Cartilaginea FRUIT EXTRACTS ON SERUM PARATHYROID HORMONE AND 1α,25-DIHYDROXYVITAMIN D3 LEVELS IN RATS

Abstract

Capparis cartilaginea is a shrub plant which used in traditional medicine to cure various diseases. Phytochemical analysis of Capparis cartilaginea plants extracts revealed the presence of isothiocyanates and flavonoids. A dose dependent study was designed to assess effects of Capparis cartilaginea fruit extract on serum parathyroid hormones (PTH) and 1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3) levels in adult male and female Wistar rats, which could describe a regulation effect on bone metabolism. Healthy adult Wistar rats (20 female and 20 male) were treated with 1000, 2000 and 3000 mg/kg body weight (BW) of fruit extract via gavage for 6 weeks. The rats were housed under standard laboratory conditions (22±1ºC and 60% humidity) for 2 weeks prior to the experiment. Blood samples were collected to determine the level of PTH and 1α,25(OH)2D3 in serum. Results of study revealed that serum PTH levels were increased in male and female rats treated with 1000, 2000 and 3000 mg/kg body Capparis cartilaginea fruit extract. The analysis of the hormones suggested a dosedependent response in male serum PTH levels and it was significantly higher than the female PTH levels. On the other hand, all the three doses of Capparis cartilaginea fruit extract decreased 1α,25(OH)2D3 levels in both genders. The results of study indicated that Capparis cartilaginea fruit extracts have a potential to change the PTH and 1α,25(OH)2D3 hormonal levels.

Mechanistic Insights into Effects of Different Dietary Polyphenol Supplements on Arsenic Bioavailability, Biotransformation, and Toxicity Based on a Mouse Model

“…Mice-fed As + QC also displayed significantly higher Trpv6 expression in the duodenum (2.00 ± 0.70 vs 0.88 ± 0.28, p < 0.05, Figure G), while ileal Trpv6 expression was also elevated although not significantly (Figure H). Studies reported increased serum PTH levels with flavonoids in rat and upregulated serum 1,25­(OH) 2 D 3 in broilers . Among the test five polyphenols, QC and EGCG are flavonoids that possess estrogen-like effects.…”

GC-MS analysis of the bioactive phytochemical compounds with anticancer activity in the Capparis cartilaginea fruit extracts

“…Then, 50 g of the dried fruit powder was used to create 11.5 g of dried extract. The final extract was stored at -80°C for later use [6].…”

“…Our research group has been studying the Capparis cartilaginea (C. cartilaginea) fruit extract and has published on the many beneficial aspects of this plant. It has been found to possibly reduce and treat osteoporosis and could alter the levels of the parathyroid hormone (PTH) and 1α,25-Dihydroxyvitamin D3 (25(OH)2D3) hormone [5,6]. Moreover, it induced morphological alterations in 22RV1 human prostate cancer cells and had a notable impact on cell death and mortality.…”