Effect of SARS-CoV-2 infection and pandemic period on healthcare-associated infections acquired in intensive care units

Lepape, Alain; Machut, Anaïs; Bretonnière, Cédric; Friggeri, Arnaud; Vacheron, Charles-Hervé; Savey, Anne

doi:10.1016/j.cmi.2022.10.023

Cited by 15 publications

(17 citation statements)

References 20 publications

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“…Lepape et al concluded that microbial epidemiology and resistance seem not to be a major problem in COVID-19 infections. Although the rate of MDR infections was low in 2020Cov patients, it was significantly higher than that observed in 2019Control and 2020NonCov groups, confirming data reported by other authors [ 10 ]. The increase in MDR prevalence [ 16 ], and in some studies the emergence and spread of difficult to treat resistant (DTR) bacteria (i.e.…”

supporting

confidence: 89%

“…In this issue of Clinical Microbiology and Infection , Lepape and colleagues [ 10 ] compared the occurrence and etiology of hospital acquired VAP, BSI and catheter-related bacteremia (CRB) in patients admitted to ICU, between 2019 (2019Control) and 2020 in COVID-19 (2020Cov) and non-COVID-19 (2020NonCov) patients, in France. Data were obtained by a continuous voluntary surveillance network on patients admitted to ICU for a minimum stay of 2 days, with 110 participating units in 2019 and 90 in 2020.…”

mentioning

confidence: 99%

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The controversial bond between COVID-19 and bacterial superinfections

Bonazzetti

Giannella

2023

Clinical Microbiology and Infection

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supporting

confidence: 89%

mentioning

confidence: 99%

The controversial bond between COVID-19 and bacterial superinfections

Bonazzetti

Giannella

2023

Clinical Microbiology and Infection

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“…However, even though our results show a high level of AMR genes among hospitals in Brazil, it is also important to consider that the samples for this study were collected between 2020-2021, when SARS-CoV-2 pandemic was widely spread around the world, and the hospitals were overcrowded, and the health professionals were overloaded. Previous studies have shown that hospitals were suffering with a higher level of HAIs during this period (48,49). Furthermore, hospital sampling was not equally distributed among all Brazilian regions, some regions are well more represented than others.…”

Section: Discussionmentioning

confidence: 86%

A transversal overview of Intensive Care Units environmental microbiome and antimicrobial resistance profile in Brazil

de Bastiani,

Silva,

Christoff

et al. 2024

Preprint

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IntroductionInfections acquired during healthcare setting stay pose significant public health threats. These infections are known as Healthcare-Associated Infections (HAI), mostly caused by pathogenic bacteria, which exhibit a wide range of antimicrobial resistance.ObjectiveCharacterize the microbiome and antimicrobial resistance genes present in high-touch Intensive Care Unit (ICU) surfaces, and to identify the potential contamination of the sanitizers/processes used to clean hospital surfaces.MethodsIn this national, multicenter, observational, and prospective cohort, bacterial profiles and antimicrobial resistance genes from 41 hospitals across 16 Brazilian states were evaluated. Using high-throughput 16S rRNA amplicon sequencing and real-time PCR, the bacterial abundance and resistance genes presence were analyzed in both ICU environments and cleaning products.ResultsWe identified a wide diversity of microbial populations with a recurring presence of HAI-related bacteria among most of the hospitals. The median bacterial positivity rate in surface samples was high (88.24%), varying from 21.62% to 100% in different hospitals. Hospitals with the highest bacterial load in samples were also the ones with highest HAI-related abundances.Streptococcus spp,Corynebacterium spp,Staphylococcus spp,Bacillus spp,Acinetobacter spp,and bacteria from the Flavobacteriaceae family were the microorganisms most found across all hospitals. Despite each hospital particularities in bacterial composition, clustering profiles were found for surfaces and locations in the ICU. Antimicrobial resistance genesmecA,blaKPC-like,blaNDM-like, andblaOXA-23-likewere the most frequently detected in surface samples. A wide variety of sanitizers were collected, with 19 different active principles in-use, and 21% of the solutions collected showed viable bacterial growth with antimicrobial resistance genes detected.ConclusionThis study demonstrated a diverse and spread pattern of bacteria and antimicrobial resistance genes covering a large part of the national territory in ICU surface samples and in sanitizers solutions. This data should contribute to the adoption of surveillance programs to improve HAI control strategies and demonstrate that large-scale epidemiology studies must be performed to further understand the implications of bacterial contamination in hospital surfaces and sanitizer solutions.

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“…In a study conducted in the Netherlands, the incidence rates of VAP and CLABSI increased during the COVID-19 pandemic, 9 and a study conducted in France also reported an increase in VAP and BSI during the pandemic. 8 On the other hand, in a study conducted in ICUs in Germany, it was reported that the rate of CLABSI did not increase during the COVID-19 pandemic, and the rate of CAUTI decreased. 7 …”

Section: Discussionmentioning

confidence: 95%

“…In previous reports, COVID-19 was reported to be associated with increased rates of healthcare-associated infections (HAIs). [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] These results could be attributed to the neglect of conventional infection control practices, such as monitoring of handwashing activities and contact precautions for multidrug-resistant organisms. On the other hand, the COVID-19 pandemic has led to the strengthening of personal protective equipment usage in healthcare facilities.…”

Section: Introductionmentioning

confidence: 99%