Effect of Sanguisorba minor on scopolamine-induced memory loss in rat: involvement of oxidative stress and acetylcholinesterase

Hosseini, Zeinab; Mansouritorghabeh, Fatemeh; Kakhki, Faezeh Sadat Hosseini; Hosseini, Mahmoud; Rakhshandeh, Hassan; Hosseini, Azar; Hasanpour, Maede; Iranshahi, Mehrdad; Rajabian, Arezoo

doi:10.1007/s11011-021-00898-y

Cited by 14 publications

(22 citation statements)

References 49 publications

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“…Finally, the supernatant absorbance was read by a spectrophotometer at a wavelength of 535 nm. The result was expressed as nmol/g tissue (Hosseini et al, 2022).

Concentration ()(, mol / normalL) goodbreak= Absorbance / 1.65 goodbreak\times 10^{5}

…”

Section: Methodsmentioning

confidence: 99%

“…After 10 min, the second absorbance was read and the change in absorbance was calculated. AchE activity was estimated by the following formula and expressed as nmol/min/tissue (g) (Hosseini et al, 2022; Ugbaja et al, 2021).

normalR goodbreak= 5.74 ()(, 10^{- 4}) ΔA / C_{0}

where R = rate in moles substrate hydrolyzed per min per tissue (g); ΔA = change in absorbance per min; and C 0 = original concentration of tissue.…”

Section: Methodsmentioning

confidence: 99%

“…The total thiol content (or sulfhydryl groups) in the brain tissue was detected using 5,5′‐dithiobis (2‐nitrobenzoic acid) (DTNB), as a reagent (Hosseini et al, 2022 ). DTNB reacts with sulfhydryl groups, and a Uv–vis spectrophotometer detects the absorbance.…”

Section: Methodsmentioning

confidence: 99%

“…The optical absorbance was measured at 570 nm. The brain tissue SOD activity was expressed as units per gram of tissue (Hosseini et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Section: Evaluation Of Ache Enzyme Levelmentioning

confidence: 99%

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Punica granatum peel supplementation attenuates cognitive deficits and brain injury in rat by targeting the Nrf2‐HO‐1 pathway

Akbarian

Hosseini

Mirzavi

et al. 2022

Food Science & Nutrition

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The critical role of nutrition to prevent neurodegenerative disorders is well documented. Punica granatum fruit is identified as a highly nutritional food for alleviating various ailments. The ameliorating properties of P. granatum peel on memory dysfunction and the possible roles of oxidative stress, acetylcholinesterase (AchE), and nuclear factor erythroid 2‐related factor 2 (Nrf2)‐heme oxygenase (HO)‐1 pathway in the scopolamine‐treated rats were assessed. The hydroethanolic extract was standardized using high‐performance liquid chromatography (HPLC). The animal groups were as follows: Control, scopolamine (2 mg/kg), and treatment groups (the extract at doses of 200–800 mg/kg). The behavioral performance was evaluated using the Morris water maze (MWM) and passive avoidance equipment. Various biochemical parameters were then measured. Rats received the extract properly found on the platform location, indicated by a shorter traveling time and distance during 5 days of learning MWM. Moreover, the extract increased the delay and light time, while decreasing dark time and the frequency of entries to the dark in the passive avoidance test. The extract also exerted a significant increase in superoxide dismutase activity and thiol content, while decreasing AchE activity and lipid peroxidation in the brain of scopolamine‐injured rats. Our results demonstrated the neuroprotective effects of P. granatum peel in minimizing scopolamine injury possibly through targeting the Nrf2‐HO‐1 pathway.

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“…Finally, the supernatant absorbance was read by a spectrophotometer at a wavelength of 535 nm. The result was expressed as nmol/g tissue (Hosseini et al, 2022).

Concentration ()(, mol / normalL) goodbreak= Absorbance / 1.65 goodbreak\times 10^{5}

…”

Section: Methodsmentioning

confidence: 99%

normalR goodbreak= 5.74 ()(, 10^{- 4}) ΔA / C_{0}

where R = rate in moles substrate hydrolyzed per min per tissue (g); ΔA = change in absorbance per min; and C 0 = original concentration of tissue.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The optical absorbance was measured at 570 nm. The brain tissue SOD activity was expressed as units per gram of tissue (Hosseini et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Section: Evaluation Of Ache Enzyme Levelmentioning

confidence: 99%

See 3 more Smart Citations

Punica granatum peel supplementation attenuates cognitive deficits and brain injury in rat by targeting the Nrf2‐HO‐1 pathway

Akbarian

Hosseini

Mirzavi

et al. 2022

Food Science & Nutrition

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Zataria multiflora and its constituent, carvacrol, counteract sepsis‐induced aortic and cardiac toxicity in rat: Involvement of nitric oxide and oxidative stress

Hosseini

Arab

Beheshti

et al. 2023

Anim Models and Exp Med

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Background: Zataria multiflora and carvacrol showed various pharmacological properties including anti-inflammatory and anti-oxidant effects. However, up to now no studies have explored its potential benefits in ameliorating sepsis-induced aortic and cardiac injury. Thus, this study aimed to investigate the effects of Z. multiflora and carvacrol on nitric oxide (NO) and oxidative stress indicators in lipopolysaccharide (LPS)-induced aortic and cardiac injury.Methods: Adult male Wistar rats were assigned to: Control, lipopolysaccharide (LPS)(1 mg/kg, intraperitoneal (i.p.)), and Z. multiflora hydro-ethanolic extract (ZME, 50-200 mg/kg, oral)-and carvacrol (25-100 mg/kg, oral)-treated groups. LPS was injected daily for 14 days. Treatment with ZME and carvacrol started 3 days before LPS administration and treatment continued during LPS administration. At the end of the study, the levels of malondialdehyde (MDA), NO, thiols, and antioxidant enzymes were evaluated. Results:Our findings showed a significant reduction in the levels of superoxide dismutase (SOD), catalase (CAT), and thiols in the LPS group, which were restored by ZME and carvacrol. Furthermore, ZME and carvacrol decreased MDA and NO in cardiac and aortic tissues of LPS-injected rats. Conclusions:The results suggest protective effects of ZME and carvacrol on LPSinduced cardiovascular injury via improved redox hemostasis and attenuated NO production. However, additional studies are needed to elucidate the effects of ZME and its constituents on inflammatory responses mediated by LPS.

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Amelioration of oxidative stress, cholinergic dysfunction, and neuroinflammation in scopolamine-induced amnesic rats fed with pomegranate seed

et al. 2022

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Effect of Sanguisorba minor on scopolamine-induced memory loss in rat: involvement of oxidative stress and acetylcholinesterase

Cited by 14 publications

References 49 publications

Punica granatum peel supplementation attenuates cognitive deficits and brain injury in rat by targeting the Nrf2‐HO‐1 pathway

Punica granatum peel supplementation attenuates cognitive deficits and brain injury in rat by targeting the Nrf2‐HO‐1 pathway

Zataria multiflora and its constituent, carvacrol, counteract sepsis‐induced aortic and cardiac toxicity in rat: Involvement of nitric oxide and oxidative stress

Amelioration of oxidative stress, cholinergic dysfunction, and neuroinflammation in scopolamine-induced amnesic rats fed with pomegranate seed

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