Effect of San’ao Decoction (三拗汤) on the airway inflammation and hyperresponsiveness in a murine model of lipopolysaccharide-enhanced asthma

Gu, Ping; Fan, Xianqun; Jiang, Chenxue; Xu, Hao; Yu, Jinghua; Tang, Yuping

doi:10.1007/s11655-011-0788-x

Cited by 11 publications

(4 citation statements)

References 7 publications

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“…[26] The pathologic mechanisms of asthma include allergic reaction, bronchial chronic inflammation, airway hyperresponsiveness, abnormality of airway neuromodulation, genetic factor, respiratory viral infection, neural signal transduction mechanism, and airway remodeling. [23,27]…”

Section: Discussionmentioning

confidence: 99%

“…[17–19] Recently, with the publication of a number of trials on SAD for asthma, they have proved that SAD has good clinical effect. [20–23] There is an urgent need for a systematic review to support the effectiveness and safety of SAD in treating asthma. Hereby, the purpose of the study is to systematically review current available articles to assess the efficacy and safety of the SAD treatment in patients of asthma.…”

Section: Introductionmentioning

confidence: 99%

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Sanao decoction for asthma

Chen

et al. 2019

Medicine

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Background: Asthma is a chronic inflammatory disease characterized by recurrent attacks of breathlessness and wheezing, which often worsen at night or in the early morning and vary from person to person in severity and frequency. Sanao decoction (SAD), as a traditional Chinese medicine compound, has a long history of clinical application in the treatment of respiratory diseases. Whereas neither systematic nor meta-analysis of randomized controlled articles explain the efficacy of SAD in treating asthma. Therefore, we provide a protocol to evaluate the efficacy and safety of SAD for asthma. Methods: From the beginning to December 2018, the following electronic databases will be searched for studies in English or Chinese: the Cochrane Library, Embase, PubMed, Web of Science, the Chinese National Knowledge Infrastructure, the Chinese Biomedical Literature Database, the Chinese Scientific Journal Database, and the Wanfang Database. Total effective rate, peak expiratory flow (PEF), forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC will be measured as primary outcomes. Meta-analysis will be performed using the Stata 15. Results: This study will provide the current evidence of asthma treated with SAD from the several points including PEF, FEV1, FVC, and FEV1/FVC. Conclusion: The consequence of this summary will furnish proof to evaluate if SAD is effective in the treatment of asthma. PROSPERO registration number: PROSPERO CRD42018117923.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sanao decoction for asthma

Chen

et al. 2019

Medicine

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“…Moreover, Rhizoma Pinelliae (Ban Xia) inhibits TNF- α -induced NF- κ B activation [53], and the extraction from Poria (Fu ling) has immunoregulatory effect [54]. In addition, San'ao decoction, a famous Chinese medicine formula composed of three herbs identified in the study, Semen Armeniacae Amarum (Xin Ren), Radix Glycyrrhizae (Gan Cao), and Herba Ephedrae (Ma Huang), has shown anti-inflammation and hyperresponsiveness in airway of a murine model [55]. …”

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Meta‐Analysis of Herbal Medicine on Chronic Obstructive Pulmonary Diseases

Chen

Ke-jian

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Herbal medicine (HM) as an adjunct therapy has been shown to be promising for the chronic obstructive pulmonary disease (COPD). However, the role of herbs in COPD remains largely unexplored. In this present study, we conducted the systematic review to evaluate the efficacy of herbs in COPD. 176 clinical studies with reporting pulmonary function were retrieved from English and Chinese database. Commonly used herbs for acute exacerbations stage (AECOPD) and stable COPD stage (SCOPD) were identified. A meta-analysis conducted from 15 high quality studies (18 publications) showed that HM as an adjunct therapy had no significant improvement in pulmonary function (FEV1, FEV%, FVC, and FEV1/FVC) compared to conventional medicine. The efficacy of the adjunct HM on improving the arterial blood gas (PaCO2 and PaO2) for AECOPD and SCOPD remains inconclusive due to the heterogeneity among the studies. However, HM as an adjunct therapy improved clinical symptoms and quality of life (total score, activity score, and impact score of St. George's Respiratory Questionnaire). Studies with large-scale and double-blind randomized controlled trials are required to confirm the role of the adjunct HM in the management of COPD.

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“…SAD may have a inhibitory effect on airway inflammation of asthmatic rats by regulating Th1/Th2 transfer factors [ 9 ]. Our recent research showed that SAD and its series of formulae could alleviate normal human bronchial epithelial cell damage and suppress airway inflammation by various ways [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of the Main Bioactive Components of San-ao Decoction and Its Series of Formulations

Shu¹,

Tang²,

Jiang³

et al. 2012

Molecules

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A high performance liquid chromatographic (HPLC) method with diode array detection (DAD) was established for simultaneous determination of seven main bioactive components in San-ao decoction and its series of formulae (San-ao decoction, Wu-ao decoction, Qi-ao decoction and Jia-wei San-ao decoction). Seven compounds were analyzed simultaneously with a XTerra C18 column (4.6 mm × 250 mm, 5 µm) using a linear gradient elution of a mobile phase containing acetonitrile (A) and a buffer solution (0.02 mol/L potassium dihydrogen phosphate and adjusted to pH 3 using phosphoric acid) (B); the flow rate was 1.0 mL/min. The sample was detected with DAD at 210, 254 and 360 nm and the column was maintained at 30 °C. All the compounds showed good linearity (r2 > 0.9984) in the tested concentration range. The precisions were evaluated by intra-day and inter-day tests, and relative standard deviation (R.S.D.) values within the range of 0.83%–2.53% and 0.64%–2.77% were reported, respectively. The recoveries of the quantified compounds were observed to cover a range from 95.34% and 104.82% with R.S.D. values less than 2.72%. The validated method was successfully applied for the simultaneous determination of seven main bioactive components including ephedrine (1), amygdalin (2), liquiritin (3), benzoic acid (4), isoliquiritin (5), formononetin (6) and glycyrrhizic acid (7) in San-ao decoction and its series of formulae. The results also showed a wide variation in the content of the identified active compounds in these samples, which could also be helpful to illustrate the drug interactions after some herbs combined in different formulations.

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Effect of San’ao Decoction (三拗汤) on the airway inflammation and hyperresponsiveness in a murine model of lipopolysaccharide-enhanced asthma

Abstract: SAD has a good therapeutic effect on airway hyperresponsiveness in the LPS-enhanced asthma model, but its definite influence on airway inflammation is not remarkable.

Cited by 11 publications

References 7 publications

Sanao decoction for asthma

Sanao decoction for asthma

A Systematic Review and Meta‐Analysis of Herbal Medicine on Chronic Obstructive Pulmonary Diseases

Comparative Analysis of the Main Bioactive Components of San-ao Decoction and Its Series of Formulations

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