Effect of samul-tang on female fertility via RAS signaling pathway in ovaries of aged mice

Kim, Jihyun; You, Sooseong

doi:10.18632/aging.203150

Cited by 5 publications

(15 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SWT administration also restored miR-223-3p, which could interact with embryo implantation-related genes (Hal, Acp5) in the uterus of aged mice (97). This transcriptome analysis result was consistent with the phenotypic findings of the protective effect of SWT on the increase of ovarian reserve, ovulated mature oocytes, and pregnancy rate in aged mice (96,97). Tao-Hong-Si-Wu Decoction (THSWD), a traditional herbal medicine, is composed of six herbs (Prunus persica, Carthamus tinctorius, Rehmannia glutinosa, Angelica sinensis, Paeonia lactiflora, and Ligustium chuanxiong).…”

Section: Transcriptome-based Elucidation Of Molecular Target And/or M...supporting

confidence: 85%

“…Si-Wu-Tang (SWT) (Samul-tang in Korean, Shimotsu-to in Japanese) is one of the most popular herbal prescriptions consisting of four herbs including Paeonia Radix, Ligusticum Rhizoma, Rehmannia Radix, and Angelica Radix at a 1:1:1:1 ratio. It has been clinically applied for centuries in Asia to treat symptoms of hematological disorders such as anemia, menstrual irregularities, dysmenorrhea, and menopausal syndrome (89)(90)(91)(92)(93)(94)(95)(96)(97). In recent years, an increasing number of studies have elucidated the MOA of SWT by analyzing SWT-induced changes in gene expression.…”

Section: Transcriptome-based Elucidation Of Molecular Target And/or M...mentioning

confidence: 99%

“…Three microRNAs (miR-200b-3p, miR-665-3p, and miR-667-3p) had binding sites on either Bmp15 or Oas1 mRNA and their expression levels were restored in SWT plus CP-treated mice. Kim and You have http://bmbreports.org BMB Reports also investigated the influence of SWT on ovarian reserve and fertilization in aged mice (＞ 40-week-old) (96,97). They performed functional enrichment analysis of transcriptome data obtained from ovulated ovaries and revealed that RAS signaling pathway-related genes were restored to normal levels as those in young mice after SWT administration to aged mice (96).…”

Section: Transcriptome-based Elucidation Of Molecular Target And/or M...mentioning

confidence: 99%

“…Kim and You have http://bmbreports.org BMB Reports also investigated the influence of SWT on ovarian reserve and fertilization in aged mice (＞ 40-week-old) (96,97). They performed functional enrichment analysis of transcriptome data obtained from ovulated ovaries and revealed that RAS signaling pathway-related genes were restored to normal levels as those in young mice after SWT administration to aged mice (96). SWT administration also restored miR-223-3p, which could interact with embryo implantation-related genes (Hal, Acp5) in the uterus of aged mice (97).…”

Section: Transcriptome-based Elucidation Of Molecular Target And/or M...mentioning

confidence: 99%

See 3 more Smart Citations

Systems pharmacology approaches in herbal medicine research: a brief review

Lee¹,

Shin²,

Park³

et al. 2022

BMB Rep

View full text Add to dashboard Cite

Herbal medicine, a multi-component treatment, has been extensively practiced for treating various symptoms and diseases. However, its molecular mechanism of action on the human body is unknown, which impedes the development and application of herbal medicine. To address this, recent studies are increasingly adopting systems pharmacology, which interprets pharmacological effects of drugs from consequences of the interaction networks that drugs might have. Most conventional network-based approaches collect associations of herb-compound, compound-target, and target-disease from individual databases, respectively, and construct an integrated network of herb-compound-target-disease to study the complex mechanisms underlying herbal treatment. More recently, rapid advances in highthroughput omics technology have led numerous studies to exploring gene expression profiles induced by herbal treatments to elicit information on direct associations between herbs and genes at the genome-wide scale. In this review, we summarize key databases and computational methods utilized in systems pharmacology for studying herbal medicine. We also highlight recent studies that identify modes of action or novel indications of herbal medicine by harnessing drug-induced transcriptome data. [

show abstract

Section: Transcriptome-based Elucidation Of Molecular Target And/or M...supporting

confidence: 85%

Section: Transcriptome-based Elucidation Of Molecular Target And/or M...mentioning

confidence: 99%

Section: Transcriptome-based Elucidation Of Molecular Target And/or M...mentioning

confidence: 99%

Section: Transcriptome-based Elucidation Of Molecular Target And/or M...mentioning

confidence: 99%

See 2 more Smart Citations

Systems pharmacology approaches in herbal medicine research: a brief review

Lee¹,

Shin²,

Park³

et al. 2022

BMB Rep

View full text Add to dashboard Cite

show abstract

“…Previously, we reported that Samul-tang (SM), comprising Paeonia lactiflora, Ligusticum striatum, Rehmannia glutinosa , and Angelica giga , improves implantation potential in aged mice. 13 This herbal preparation has been traditionally used to manage infertility symptoms in humans and rodent models. 14 , 15 In this study, we explored uterine transcriptomic changes in the metestrus phase of the estrous cycle in the aged and hormonally stimulated uteri of mice.…”

Section: Introductionmentioning

confidence: 99%

Restoration of miR-223-3p expression in aged mouse uteri with Samul-tang administration

Kim

You

2022

Integrative Medicine Research

Self Cite

View full text Add to dashboard Cite

Background During the secretory phase of the estrous cycle, endometrium senescence is accompanied by biological mechanisms such as metabolic dysfunction and epigenetic changes, leading to decreased embryo receptivity and implantation failure. Samul-tang has been reported to improve implantation potential in aged mice. Methods To uncover the age-related changes in the transcriptomes, we performed QuantSeq 3′mRNA sequencing to compare the mRNA expression patterns in the uteri between young and old mice. Young and old female BALB/c mice were administered distilled water or Samul-tang for 4 weeks, and the corresponding effects on the uteri of aged mice were investigated. Results We found 586 differentially expressed genes between the young and old mouse groups. Functional annotation analysis revealed 10 important pathways, including arachidonic acid metabolism and glutathione metabolism, involved in uterine cellular proliferation and decidualization. Using in silico analysis, we identified the three most abundantly interacting microRNAs―miR-223–3p, 155–5p, and 129–5p―with differentially expressed genes associated with important biological pathways. Samul-tang administration restored the expression of miR-223–3p, which could interact with important genes such as histamine ammonia-lyase ( Hal ) and acid phosphatase 5 ( Acp5 ) for embryo implantation. Conclusion Our study demonstrated that uterine aging changes the expression of genes involved in metabolic pathways that are crucial to uterine health, leading to cellular senescence. We postulate that the regulation of miR-223–3p via Samul-tang administration can be of therapeutic importance in cellular senescence.

show abstract

Hyperbaric Oxygen Treatment Ameliorates the Decline in Oocyte Quality and Improves the Fertility of Aged Female Mice

Zhong

Chen

et al. 2022

Reprod. Sci.

View full text Add to dashboard Cite

The age-related decay in oocyte quality contributes to the gradual decline in fertility and the final occurrence of natural sterility. In this study, we aimed to investigate the effects of the hyperbaric oxygen treatment (HBOT) on oocyte quality in aging mouse oocyte. Eight- and forty-week-old female C57BL/6 J mice were treated with HBO for 10 days, and the quality of oocytes was analyzed. The results revealed that HBOT improved the age-related serum AMH levels. While compared with untreated aged mice, HBOT showed reduced follicular apoptosis and improved oocyte maturation, fertilization, and blastocyst formation in aged mice. HBO triggered changes in the microRNA expression in the ovaries of aged mice. In this study, 27 DEGs were identified in the HBOT mouse ovarian tissues, of which 9 were upregulated and 18 were downregulated. Notably, KEGG analysis revealed that these genes involved in different biological processes differed significantly in the ovary. Among these, the PI3K-Akt signaling was the most prominent pathway that controlled the recruitment and growth of primordial follicles. The calcium signaling pathway was found to be involved during the peri-implantation period. These results suggest that HBOT can be applied to improve the quality of oocytes, and it could be a potential clinical application to improve the fertility of aged female.

show abstract

Effect of samul-tang on female fertility via RAS signaling pathway in ovaries of aged mice

Cited by 5 publications

References 45 publications

Systems pharmacology approaches in herbal medicine research: a brief review

Systems pharmacology approaches in herbal medicine research: a brief review

Restoration of miR-223-3p expression in aged mouse uteri with Samul-tang administration

Hyperbaric Oxygen Treatment Ameliorates the Decline in Oocyte Quality and Improves the Fertility of Aged Female Mice

Contact Info

Product

Resources

About