Effect of Salts on the Thermal Stability of Physically Crosslinked Gelatin Hydrogels

Zhang, Jianlong; Qiao, Chuanling; Liu, Weiliang; Liu, Qinze

doi:10.7317/pk.2017.41.4.702

Cited by 1 publication

(1 citation statement)

References 26 publications

(34 reference statements)

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“…However, gelatin is a thermal gel that turns into a solution above 37°C, and the printing accuracy is so low that it cannot be directly used as bioink[ 108 ]. Therefore, combining gelatin with other biological materials or chemical modification is the main method of applying gelatin[ 109 ]. GelMA is a photo-cross-linked hydrogel formed by modified gelatin with methacryloyl group (MA), and the chemical modification of gelatin only involves less than 5% of the amino acid residues in molar ratio, which will not significantly decrease the arginyl-glycyl-aspartic acid (RGD) content of the gelatin[ 110 ].…”

Section: Bioinks For 3d Bioprintingmentioning

confidence: 99%

Three-dimensional bioprinting of artificial blood vessel: Process, bioinks, and challenges

Hou¹,

Cui²,

Qin³

et al. 2023

IJB

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The coronary artery bypass grafting is a main treatment for restoring the blood supply to the ischemic site by bypassing the narrow part, thereby improving the heart function of the patients. Autologous blood vessels are preferred in coronary artery bypass grafting, but their availability is often limited by due to the underlying disease. Thus, tissue-engineered vascular grafts that are devoid of thrombosis and have mechanical properties comparable to those of natural vessels are urgently required for clinical applications. Most of the commercially available artificial implants are made from polymers, which are prone to thrombosis and restenosis. The biomimetic artificial blood vessel containing vascular tissue cells is the most ideal implant material. Due to its precision control ability, three-dimensional (3D) bioprinting is a promising method to prepare biomimetic system. In the 3D bioprinting process, the bioink is at the core state for building the topological structure and keeping the cell viable. Therefore, in this review, the basic properties and viable materials of the bioink are discussed, and the research of natural polymers in bioink, including decellularized extracellular matrix, hyaluronic acid, and collagen, is emphasized. Besides, the advantages of alginate and Pluronic F127, which are the mainstream sacrificial material during the preparation of artificial vascular graft, are also reviewed. Finally, an overview of the applications in the field of artificial blood vessel is also presented.

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Section: Bioinks For 3d Bioprintingmentioning

confidence: 99%