Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID-19 pandemic: A review

Dl-3-n-butylphthalide attenuates cerebral ischemia/reperfusion injury in mice through AMPK-mediated mitochondrial fusion

“…Stroke, a disease characterized by a substantial disability rate and elevated mortality rate, has emerged as a prominent contributor to global mortality rates in recent times, with ischemic stroke (IS) being the prevailing subtype ( Wang et al, 2021 ; Xie et al, 2024 ). According to the latest epidemiological survey results, there are about 2.4 million new stroke patients in China every year, most of whom will be left with varying degrees of neurological dysfunction, which brings a serious burden to patients, families and society ( Zhu et al, 2024 ). In recent years, extensive research has been conducted on the pathological mechanisms underlying brain ischemia/reperfusion (I/R) injury, including the excessive production of reactive oxygen species (ROS), disturbances in calcium ion (Ca 2+ ) homeostasis, excitotoxic effects, apoptosis, and mitophagy.…”

Editorial: Exploring the key targets and compounds that manipulate brain neurocircuits against mental disorders and psychiatric

“…Natural products and compounds are vital resources of exploring new treatments for mental disorders ( Zhu et al, 2024 ). In this Research Topic entitled “ Exploring the Key Targets and Compounds That Manipulate Brain Neurocircuits Against Mental Disorders and Psychiatric ”, there are four original research works that demonstrate the protective effects and therapeutic value for stress-induced psychiatric symptoms, including bioactive compound ginsenosides Rb1 and Rg1 ( Jiang et al ), Fraxetin ( Ahmed et al ), fresh Gastrodia products ( Zhang et al ) and traditional Chinese drugs called Chaihu-jia-Longgu-Muli-tang (CLM, Zhao et al ).…”