Effect of Salicylic Acid on Mitochondrial-Peroxisomal Fatty Acid Catabolism

Yoshida, Yasuhiko; Fujii, Miharu; Brown, Frank R.; Singh, Inderjit

doi:10.1203/00006450-198803000-00021

Cited by 25 publications

(17 citation statements)

References 22 publications

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“…On the other hand, the long-chain acylCoA synthetases for palmitic acid were inhibited by salicylic acid 20,21,25 , diclofenac 20 , ibuprofen 26 , ketoprofen 26 , naproxen 26 , rosiglitazone 27 , thiazolidinediones 28 and troglitazone 29 . Further, arachidonic acid (AA) metabolism in brain has been reported to be a target of valproic acid 30 .…”

Section: Short Communicationmentioning

confidence: 99%

“…The medium-chain acyl-CoA synthetases for octanoic acid were inhibited by salicylic acid [20][21][22][23] , enoxacin 23 and triacsin C 24 . On the other hand, the long-chain acylCoA synthetases for palmitic acid were inhibited by salicylic acid 20,21,25 , diclofenac 20 , ibuprofen 26 , ketoprofen 26 , naproxen 26 , rosiglitazone 27 , thiazolidinediones 28 and troglitazone 29 .…”

Section: Short Communicationmentioning

confidence: 99%

“…In particular cases, the acylation at serine-3 of peptide hormone with octanoic acid, as in ghrelin, confers its biological activity 14,15 . There are many reports that the pathology of Reye's syndrome [5][6][7][8][9] and the influenza-associated acute encephalopathy [10][11][12][13] might be associated with the inhibition of many mitochondrial enzymes involved in fatty acid metabolism. Free fatty acids (particularly octanoic acid) in serum and total lipids in the liver of Reye's syndrome patients were elevated during illness 16 .…”

Section: Introductionmentioning

confidence: 99%

“…Free fatty acids (particularly octanoic acid) in serum and total lipids in the liver of Reye's syndrome patients were elevated during illness 16 . Then, aspirin and salicylate have been identified as being associated with the development of Reye's syndrome, which occurs after an infectious illness, typically chickenpox or influenza A or B [5][6][7][8][9] . In Japan, it has been recognized that aspirin, diclofenac and mefenamic acid may serve a causal role in the development of influenza-associated acute encephalopathy [10][11] .…”

Section: Introductionmentioning

confidence: 99%

“…The changes in fatty acid composition of membrane phospholipids may play an important role in the pathology of neurological disorders [1][2][3][4] . On the other hand, the disturbances in fatty acid metabolism may be associated with the development of Reye's syndrome [5][6][7][8][9] or the influenzaassociated acute encephalopathy [10][11][12][13] . In particular cases, the acylation at serine-3 of peptide hormone with octanoic acid, as in ghrelin, confers its biological activity 14,15 .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effect of the non-steroidal anti-inflammatory drugs on the acyl-CoA synthetase activity toward medium-chain, long-chain and polyunsaturated fatty acids in mitochondria of mouse liver and brain

Kasuya

Misumi

Hasegawa

et al. 2012

Journal of Enzyme Inhibition and Medicinal Chemistry

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Section: Short Communicationmentioning

confidence: 99%

Section: Short Communicationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of the non-steroidal anti-inflammatory drugs on the acyl-CoA synthetase activity toward medium-chain, long-chain and polyunsaturated fatty acids in mitochondria of mouse liver and brain

Kasuya

Misumi

Hasegawa

et al. 2012

Journal of Enzyme Inhibition and Medicinal Chemistry

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Toxicity and Drug Safety

Schrör

2008

Acetylsalicylic Acid

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Decreased mitochondrial oxidation of fatty acids in pregnant mice: Possible relevance to development of acute fatty liver of pregnancy

et al. 1993

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Severe impairment of the beta-oxidation of fatty acids, as a consequence of a single factor or a combination of different causes, leads to microvesicular steatosis of the liver. In an effort to understand the mechanism(s) leading to the development of acute fatty liver of pregnancy in some women, we determined the effects of pregnancy on the mitochondrial oxidation of fatty acids in mice. In vivo, the rate of oxidation of the whole fatty-acid chain length was determined by measuring the rate of exhalation of [14C]CO2 after intragastric administration of a tracer dose of [U-14C]palmitic acid. [14C]CO2 exhalation was not significantly decreased at 14 days of gestation, but it had declined by 40% at 18 days of gestation (i.e., 24 to 48 hr before delivery). The rate of first beta-oxidation cycle was assessed by measuring the rate of [14C]CO2 exhalation after administration of [1-14C]octanoic acid, [1-14C]butyric acid or [1-14C]palmitic acid. [14C]CO2 exhalation had declined by 60%, 46%, and 24% after administration of [1-14C]octanoic acid, [1-14C]butyric acid and [1-14C]palmitic acid, respectively, in 18-day-pregnant mice. Total hepatic lipids and triglycerides, expressed per gram of liver, remained unchanged in 18-day-pregnant mice. In vitro, the rate of mitochondrial beta-oxidation (expressed per milligram of protein) had decreased by 47% at 18 days' gestation with [U-14C]palmitic acid as substrate and by 33% with [1-14C]octanoic acid but remained unchanged with [1-14C]palmitic acid. The activity of the tricarboxylic acid cycle, assessed by the formation of [14C]CO2 from [1-14C]acetic acid, had decreased by 24%. We conclude that the mitochondrial oxidation of fatty acids decreased during late-term pregnancy in mice as a consequence of both decreased mitochondrial beta-oxidation of medium-chain fatty acids, and decreased activity of the tricarboxylic acid cycle. We suggest that this effect, in combination with other factors, may contribute to the development of fatty liver of pregnancy in some pregnant women.

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Effect of Salicylic Acid on Mitochondrial-Peroxisomal Fatty Acid Catabolism

Cited by 25 publications

References 22 publications

Effect of the non-steroidal anti-inflammatory drugs on the acyl-CoA synthetase activity toward medium-chain, long-chain and polyunsaturated fatty acids in mitochondria of mouse liver and brain

Effect of the non-steroidal anti-inflammatory drugs on the acyl-CoA synthetase activity toward medium-chain, long-chain and polyunsaturated fatty acids in mitochondria of mouse liver and brain

Toxicity and Drug Safety

Decreased mitochondrial oxidation of fatty acids in pregnant mice: Possible relevance to development of acute fatty liver of pregnancy

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