Effect of salicylate on the acid-base equilibrium of patients with chronic CO2 retention due to pulmonary emphysema

Wégria, René; Capeci, Nicholas E.; Kiss, George T.; Glaviano, Vincent V.; Keating, John H.; Hilton, James G.

doi:10.1016/0002-9343(55)90343-0

Cited by 19 publications

(2 citation statements)

References 9 publications

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“…However, aspirin caused a sharp rise in CO2 production and this may have canceled the effect of hyperventilation in so far as lowering the arterial CO2 tension was concerned. The ability of aspirin to lower the Paco2 in hypercapnia has been claimed by some (13) and disputed by others (14). It is of interest that in another study in this laboratory, on individuals without heart or lung disease, progesterone produced approximately the same decline in alveolar CO2 tension as did aspirin, 2 Gm.…”

Section: Methodsmentioning

confidence: 84%

The Effect of Progesterone on the Respiration of Patients With Emphysema and Hypercapnia*

Tyler¹

1960

J. Clin. Invest.

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The possibility that progesterone could influence breathing was first suggested by studies investigating the respiration of pregnant women. In 1912 Leimdorfer, Novak and Porges (1) found that the alveolar concentration of CO2 was lower in pregnant women than it was in the same individuals when they were not.pregnant. These observations were amplified and confirmed in 1915 by Hasselbalch and Gammeltoft (2). Beginning in 1947, Dbring, Heerhaber and co-workers (3-5) investigated the effect of pregnancy in lowering the alveolar CO2 tension and later extended the studies to measurements of CO, tension made during the normal menstrual cycle. They were able to show that the alveolar CO2 tension was depressed in the luteal phase of the cycle and that if pregnancy occurred this depression continued throughout gestation, rising shortly after delivery. This suggested to them that progesterone might play a role in the genesis of the decrease in alveolar CO2 tension and they were able to show that 50 mg. of progesterone given intramuscularly to normal men caused a stimulus to breathing which reached its maximum about 12 hours after injection.Persistent hypercapnia is a frequent finding in the terminal stages of chronic pulmonary disease. Present long-term methods for lowering this hypercapnia are not satisfactory. Since Daring and Heerhaber's studies were limited to single injections of progesterone, and because the effect of progesterone on respiration in the presence of hypercapnia was not known, the following studies were done to investigate the effect of repeated injections of progesterone on the respiration of patients with chronic pulmonary disease and elevated levels of arterial pCO2. In an attempt to evaluate

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Section: Methodsmentioning

confidence: 84%

The Effect of Progesterone on the Respiration of Patients With Emphysema and Hypercapnia*

Tyler¹

1960

J. Clin. Invest.

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“…-Wegria, Capeci, Kiss, Glaviano, Keating, and Hilton (1955) have shown that similar doses of sodium salicylate reduce the arterial pCO2 in patients with respiratory failure due to chronic lung disease. Our results confirm these findings.…”

Section: Discussionmentioning

confidence: 99%

Effects of Aminophylline, Nikethamide, and Sodium Salicylate in Respiratory Failure

Westlake¹,

Campbell²

1959

BMJ

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Das Lungenemphysem

Lottenbach¹

1956

Erkrankungen Der Atmungsorgane

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Effect of salicylate on the acid-base equilibrium of patients with chronic CO2 retention due to pulmonary emphysema

Cited by 19 publications

References 9 publications

The Effect of Progesterone on the Respiration of Patients With Emphysema and Hypercapnia*

The Effect of Progesterone on the Respiration of Patients With Emphysema and Hypercapnia*

Effects of Aminophylline, Nikethamide, and Sodium Salicylate in Respiratory Failure

Das Lungenemphysem

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