Effect of Salbutamol on Respiratory Function in Children With Asthma

Bass, Brittany; Disney, M. E.; Morrison-Smith, J.

doi:10.1016/s0140-6736(69)90151-2

Cited by 14 publications

(4 citation statements)

References 3 publications

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“…[ 14 ] But on the other hand, the response to the stress of the patients may cause the BW gain by fluid retention, which is through the secretion of antidiuretic hormone, renin, and aldosterone. [ 15 ] In the aspect of fluid retention, excessive fluid accumulation is not only demonstrated to link with the raised morbidities and mortality in patients with critical illness or AKI, and those undergoing major surgeries, [ 16 , 17 ] but also shown to be associated with higher risk of subsequent AKI. [ 18 ]…”

Section: Introductionmentioning

confidence: 99%

Perioperative body weight change is associated with in-hospital mortality in cardiac surgical patients with postoperative acute kidney injury

et al. 2017

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BackgroundPostoperative acute kidney injury (AKI) is common following cardiac surgery (CS). Body weight (BW) may be an amenable variable by representing the summation of the nutritional and the fluid status. However, the predictive role of perioperative BW changes in CS patients with severe postoperative AKI is never explored. This study aimed to evaluate this association.MethodsThis study was conducted using a prospectively collected multicenter cohort, NSARF (National Taiwan University Hospital Study Group on Acute Renal Failure) database. The adult CS patients with postoperative AKI requiring renal replacement therapy (RRT), who had clear initial consciousness, received CS within 14 days of hospitalization, and underwent RRT within seven days after CS in intensive care units from January 2001 to January 2014 were enrolled. With the endpoint of 30-day postoperative mortality, we evaluated the association between the clinical factors denoting fluid status and patients outcomes.ResultsA total of 188 patients (70 female, mean age 63.7 ± 15.2 years) were enrolled. Comparing with the survivors (n = 124), the non-survivors (n = 64) had a significantly higher perioperative BW change [3.6 ± 6.1% versus 0.1 ± 8.3%, p = 0.003] but not the postoperative and pre-RRT BW changes. By using multivariate Cox proportional hazards model, the independent indicators of 30-day postoperative mortality included perioperative BW change (p = 0.026) and packed red blood cells transfusion (p = 0.007), postoperative intra-aortic balloon pump (p = 0.001) and central venous pressure level (p = 0.005), as well as heart rate (p = 0.022), sequential organ failure assessment score (p < 0.001), logistic organ dysfunction score (p = 0.001), and blood total bilirubin level (p = 0.044) at RRT initiation. The generalized additive models further demonstrated, in a multivariate manner, that the mortality risk rose significantly during a perioperative BW change of 2% to 15%.ConclusionsPerioperative BW change was independently associated with an increased risk for 30-day postoperative mortality in CS patients with RRT-requiring AKI.

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Section: Introductionmentioning

confidence: 99%

Perioperative body weight change is associated with in-hospital mortality in cardiac surgical patients with postoperative acute kidney injury

et al. 2017

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“…The first report of such effects in children was in 1969, when a significant fall in arterial blood oxygen saturation was found in asthmatic children after they inhaled salbutamol, even though this improved forced expiratory volume in one second in the same period 9. A later study recorded a fall in arterial oxygen saturation of more than 5% in nine out of 18 asthmatic children aged 2-15 years who were treated with salbutamol nebulised with air 10.…”

Section: Resultsmentioning

confidence: 99%

Oxygen treatment for acute severe asthma

Inwald

Roland

Kuitert

et al. 2001

BMJ

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Deaths from asthma in England and Wales dropped by about 6% a year in people aged 5-64 from 1983 to 1995, 1 but about 20 children and 1600 adults still die in the United Kingdom every year from acute asthma. Profound hypoxaemia may be a readily preventable cause of some of these deaths. The British Thoracic Society's asthma guidelines advise oxygen as first line treatment in hospital for all patients in cases of acute severe asthma.2 However, the guidelines do not advise treatment with oxygen in primary care in children and do not insist on its use in adults. The recent death of a child in a primary care setting after administration of salbutamol nebulised with air prompted us to question whether treatment with oxygen should be recommended in all cases of acute severe asthma, including those presenting in primary care. MethodsA systematic review was not possible as there have never been any randomised controlled trials of oxygen in acute severe asthma. We therefore present a traditional literature review and our opinion based on it. We selected 24 publications from our personal collections and from Medline searches. Using the search terms "asthma" and "hypoxaemia or hypoxemia or hypoxia or oxygen" and "salbutamol or albuterol" yielded 204 papers, of which 11 were included in this review. The other 13 papers that we evaluated were from our personal collections. Results and discussionIn acute severe asthma, narrowing of the airway occurs as a result of bronchospasm, mucosal oedema, and hypersecretion. The homoeostatic response to this is to decrease blood flow to underventilated lung units, thus maximising oxygenation by matching pulmonary perfusion with alveolar ventilation. This was shown in an elegant series of studies spanning nearly two decades that used the multiple inert gas technique to study ventilation-perfusion relations and gas exchange in asthmatic patients with varying degrees of disease severity. [3][4][5]

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“…No adverse cardiac effects were observed in 19 asthmatic children given 0.2 mg salbutamol by aerosol inhalation (Bass et al, 1969). In another study in 10 asthmatic patients aerosol inhalation of 0.2 mg salbutamol did not increase cardiac output whereas 0.8 mg isoprenaline by aerosol inhalation did cause a statistically significant increase in cardiac output (Kelman et al, 1969).…”

Section: Cardiovascular Effectsmentioning

confidence: 96%