Effect of saffron supplementation on oxidative stress markers (MDA, TAC, TOS, GPx, SOD, and pro-oxidant/antioxidant balance): An updated systematic review and meta-analysis of randomized placebo-controlled trials

Abedi, Ali; Ghobadi, Hassan; Sharghi, Afshan; Iranpour, Sohrab; Fazlzadeh, Mehdi; Aslani, Mohammad Reza

doi:10.3389/fmed.2023.1071514

Cited by 9 publications

(3 citation statements)

References 62 publications

(72 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MDA is the most common lipid marker of oxidative stress ( Abedi et al, 2023 ). In this study, MDA levels were markedly high in the AD-fed ApoE −/− mice ( p < 0.001, Figure 1D ).…”

Section: Resultsmentioning

confidence: 99%

Kefir peptides attenuate atherosclerotic vascular calcification and osteoporosis in atherogenic diet-fed ApoE−/− knockout mice

Chang

Cheng

Fan

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Aims: Vascular calcification (VC) and osteoporosis were previously considered two distinct diseases. However, current understanding indicates that they share common pathogenetic mechanisms. The available medicines for treating VC and osteoporosis are limited. We previously demonstrated that kefir peptides (KPs) alleviated atherosclerosis in high-fat diet (HFD)-induced apolipoprotein E knockout (ApoE−/−) mice. The present study further addressed the preventive effects of KPs on VC and osteoporosis in ApoE−/− mice fed a high-cholesterol atherogenic diet (AD).Main methods: Seven-week-old ApoE−/− and wild-type C57BL/6 mice were randomly divided into five groups (n = 6). The development of VC and osteoporosis was evaluated after AD feeding for 13 weeks in KP-treated ApoE−/− mice and compared to C57BL/6 and ApoE−/− mice fed a standard chow diet (CD).Key findings: The results indicated that KP-treated ApoE−/− mice exhibited lower serum total cholesterol, oxidized low-density lipoprotein (ox-LDL), malondialdehyde (MDA) levels, and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatine kinase (CK) activities, which suggested that KPs prevented hyperlipidemia and possible damages to the liver and muscle in ApoE−/− mice. KPs reduced serum tumor necrosis factor-α (TNF-α) and the local expression of TNF-α, IL-1β, and macrophage-specific CD68 markers in aortic tissues, which suggested that KPs inhibited inflammatory responses in AD-fed ApoE−/− mice. KPs reduced the deposition of lipid, collagen, and calcium minerals in the aortic roots of AD-fed ApoE−/− mice, which suggested that KPs inhibited the calcific progression of atherosclerotic plaques. KPs exerted osteoprotective effects in AD-fed ApoE−/− mice, which was evidenced by lower levels of the bone resorption marker CTX-1 and higher levels of the bone formation marker P1NP. KPs improved cortical bone mineral density and bone volume and reduced trabecular bone loss in femurs.Significance: The present data suggested that KPs attenuated VC and osteoporosis by reducing oxidative stress and inflammatory responses in AD-fed ApoE−/− mice. Our findings contribute to the application of KPs as preventive medicines for the treatment of hyperlipidemia-induced vascular and bone degeneration.

show abstract

“…MDA is the most common lipid marker of oxidative stress ( Abedi et al, 2023 ). In this study, MDA levels were markedly high in the AD-fed ApoE −/− mice ( p < 0.001, Figure 1D ).…”

Section: Resultsmentioning

confidence: 99%

Kefir peptides attenuate atherosclerotic vascular calcification and osteoporosis in atherogenic diet-fed ApoE−/− knockout mice

Chang

Cheng

Fan

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…Also, traditionally, medicinal plants have been used to prevent human diseases (Rashidmayvan et al, 2022). Various studies have also been conducted to determine their effects (Abedi et al, 2023; Li et al, 2021; Mohsenzadeh et al, 2016; Xu et al, 2023; Yang et al, 2023; Zhang et al, 2019). Rhus coriaria L., known commonly as sumac, is a well‐known spice in the Anacardiaceae family that grows throughout the Middle East and North Africa (Boivin et al, 2014; Rayne & Mazza, 2007).…”

Section: Introductionmentioning

confidence: 99%

Effects of sumac supplementation on lipid profile: A systematic review and meta‐analysis of randomized controlled trials

Bahari,

Taheri,

Namkhah

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

This systematic review aimed to gather data on the effects of sumac supplementation on lipid profile. A systematic literature search was carried out using electronic databases (PubMed, Scopus, and Web of Science) up to March 2023 to identify eligible randomized controlled trials (RCTs) assessing the effects of sumac intake on lipid profile as an outcome. All participants enrolled in our study were adult individuals who consumed sumac, in various forms, as an intervention. The included articles were assessed using the Cochrane risk of bias assessment tool. Heterogeneity tests of the selected trials were performed using the I2 statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95% confidence interval. In total, seven RCTs with a total sample size of 570 subjects were included. This study found a significant decrease in total cholesterol (TC) (weighted mean difference [WMD]: −10.01 mg/dL; 95% CI: −18.67, −1.34), triglyceride (TG) (WMD: −8.52 mg/dL; 95% CI: −14.79, −2.25), and low‐density lipoprotein (LDL)‐C levels (WMD: −9.25 mg/dL; 95% CI: −14.56, −3.93); Moreover, a significant increase was observed in high‐density lipoprotein (HDL)‐C concentration (WMD: 2.97 mg/dL; 95% CI: 0.75, 5.19). The reduction in TG and TC was greater in studies with a duration of ≥12 compared to <12 weeks. The increase in HDL‐C was greater in participants with an intervention duration of ≥12 compared to <12 weeks. Moreover, subgroup analysis based on the dose of sumac suggested a significant reduction in TC and LDL, specifically for doses below 3 g. Consumption of sumac significantly decreased serum TC, LDL‐C, and TG concentrations. This study suggested significantly positive effects on HDL‐C by intake of sumac. Longer interventions (>12 weeks) have a more favorable impact on TC, LDL‐C, and HDL‐C, while sumac doses below 3 g/day show greater effects on TC and LDL‐C. These findings underscore the potential of sumac supplementation as a valuable approach to lipid profile management.

show abstract

Cardioprotective of Saffron (Crocus sativus L.) treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Prameswari,

Kalanjati,

Yuliawati

et al. 2023

Digital Chinese Medicine

View full text Add to dashboard Cite

Effect of saffron supplementation on oxidative stress markers (MDA, TAC, TOS, GPx, SOD, and pro-oxidant/antioxidant balance): An updated systematic review and meta-analysis of randomized placebo-controlled trials

Cited by 9 publications

References 62 publications

Kefir peptides attenuate atherosclerotic vascular calcification and osteoporosis in atherogenic diet-fed ApoE−/− knockout mice

Kefir peptides attenuate atherosclerotic vascular calcification and osteoporosis in atherogenic diet-fed ApoE−/− knockout mice

Effects of sumac supplementation on lipid profile: A systematic review and meta‐analysis of randomized controlled trials

Cardioprotective of Saffron (Crocus sativus L.) treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Contact Info

Product

Resources

About