Effect of saffron oral capsule on anxiety and quality of sleep of diabetic patients in a tertiary healthcare facility in southeastern Iran: A quasi-experimental study

Shahdadi, Hosien; Balouchi, Abbas; Dehghanmehr, Sadegh

doi:10.4314/tjpr.v16i11.24

Cited by 11 publications

(27 citation statements)

References 8 publications

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“…We included 8 studies with 431 participants [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ] ( Table 1 ). One study was reported in two reports (Lopresti et al, 2020; Lopresti et al, 2021) and was referred to as Lopresti et al, (2021).…”

Section: Resultsmentioning

confidence: 99%

“…Five of the eight studies were conducted in high-income countries [ 24 , 25 , 26 , 27 , 31 ], and three studies were conducted in middle-income countries [ 28 , 29 , 30 ]. Four studies recruited participants from healthcare settings [ 24 , 28 , 29 , 30 ], and three recruited participants from social media, posters, and local newspapers [ 25 , 27 , 31 ]. One study did not mention the setting from which the participants were recruited [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…One study did not mention the setting from which the participants were recruited [ 26 ]. Two studies reported insomnia participants with an underlying comorbidity of diabetes mellitus [ 28 , 30 ] and six reported insomnia participants with no comorbidity [ 24 , 25 , 26 , 27 , 29 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…Participants in the studies were randomized into intervention and control groups. For eight studies, the intervention was a single dose of saffron per day [ 24 , 26 , 27 , 28 , 29 , 30 , 31 ], and one study included two groups each receiving different saffron dosages, 14 mg and 28 mg [ 25 ]. The total doses of saffron extract used in the studies were 0.6 mg per day [ 26 ], 7.5 mg per day [ 24 , 31 ], 8 mg intranasally [ 29 ], 15.5 mg per day [ 27 ], 28 mg per day [ 25 ], 100 mg per day [ 30 ], and 300 mg per day [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

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Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis

Munirah

Norhayati

Noraini

2022

IJERPH

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Insomnia is a common complaint affecting human performance in daily life activities. This study aimed to analyze the effects of Crocus sativus on insomnia. Methods: PRISMA guidelines were used according to the PICOS model. A systematic search of PubMed/Medline and the Cochrane Library was undertaken for literature until December 2021. A random effects model was used with I2 statistic to assess heterogeneity and a GRADE assessment was used to assess the quality of the outcomes. Eight articles were included, involving 431 participants. Crocus sativus reduced insomnia severity (SMD: 0.53; 95%CI: −0.05 to 1.11; I2 statistic = 59%; p = 0.08) and increased sleep quality (SMD 0.89, 95% CI 0.10 to 1.68; I2 statistic = 90%; p = 0.03; 6 studies, 308 participants, very low-quality evidence) and duration (SMD: 0.57; 95%CI: 0.21 to 0.93; I2 statistic = 40%; p = 0.002; 5 studies; 220 participants, moderate-quality evidence) compared with the placebos. Although there is limited evidence of a very low- to moderate-quality, Crocus sativus may benefit people with insomnia. This non-pharmacological intervention may reduce the chance of adults with insomnia taking sedative–hypnotic medication, thus reducing dependency and withdrawal symptoms.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis

Munirah

Norhayati

Noraini

2022

IJERPH

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“…In a study conducted by Kell et al [15], saffron at dosages of 22 mg/day and 28 mg/day for 4 weeks significantly improved the quality of sleep in healthy adults. In another study, after saffron intake at a dosage of 300 mg/day for 7 days there were beneficial effects in reducing anxiety and improving the quality of sleep among diabetic patients [35]. Also, in an animal study by Masaki et al [36], crocin increased the total time of non-REM sleep in mice.…”

Section: Discussionmentioning

confidence: 99%

The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial

Khalatbari-mohseni

Banafshe

Mirhosseini

et al. 2019

Subst Abuse Treat Prev Policy

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Background Methadone maintenance treatment (MMT) might be associated with the symptoms of depression and anxiety, sleep disturbances and sexual dysfunctions. This study was designed to determine the effects of crocin on psychological parameters in patients under MMT. Methods Patients under MMT were randomly allocated into two groups to receive either 30 mg/day crocin (2 plus crocin tablet, 15 mg BID) ( n = 25) or placebo (2 tablets per day, 15 mg BID) ( n = 25), one hour after taking food, for 8 weeks. Psychological parameters were evaluated at baseline and end of the trial to determine related associations between crocin and patients’ mental health status. Results After 8-week intervention, crocin significantly decreased Beck Depression Inventory (b − 6.66; 95% CI, − 9.88, − 3.45; P < 0.0001), Beck Anxiety Inventory (b − 4.35; 95% CI, − 5.94, − 2.75; P < 0.0001), general health questionnaire (b − 4.45; 95% CI, − 7.68, − 1.22; P = 0.008) and Pittsburgh Sleep Quality Index (b − 2.73; 95% CI, − 3.74, − 1.73; P < 0.0001) in patients under MMT, compared with the placebo. Crocin also significantly improved International Index of Erectile Functions (b 4.98; 95% CI, 2.08, 7.88; P = 0.001) rather than placebo. Conclusion Our findings indicated that taking crocin for 8 weeks by patients under MMT had beneficial effects on their mental health status. Crocin can be recommended as an adjunct to methadone in opioid withdrawal protocols because of the ability to improve the quality of life and decrease opioids side effects in these patients. This trial was registered in the Iranian website for clinical trials registry as http://www.irct.ir : IRCT2017110537243N1. Clinical trial registration number www.irct.ir: http://www.irct.ir: IRCT2017110537243N1 .

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Therapeutic potential of hypnotic herbal medicines: A comprehensive review

Ghasemzadeh Rahbardar,

Hosseinzadeh

2024

Phytotherapy Research

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Insomnia affects millions of people worldwide, prompting considerable interest in herbal remedies for its treatment. This review aims to assess the therapeutic potential of such remedies for insomnia by analyzing current scientific evidence. The analysis identified several herbs, including Rosmarinus officinalis, Crocus sativus, Rosa damascena, Curcuma longa, Valeriana officinalis, Lactuca sativa, Portulaca oleracea, Citrus aurantium, Lippia citriodora, and Melissa officinalis, which show promise in improving overall sleep time, reducing sleep latency, and enhancing sleep quality. These plants act on the central nervous system, particularly the serotonergic and gamma‐aminobutyric acid (GABA)ergic systems, promoting sedation and relaxation. However, further research is necessary to fully understand their mechanisms of action, optimal dosages, and treatment protocols. Combining herbal medicines with conventional treatments may offer an effective natural alternative for those seeking medication. Nevertheless, individuals should consult their healthcare provider before using herbal remedies for insomnia. While this review provides evidence supporting their use, additional high‐quality studies are needed to firmly establish their clinical efficacy.

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Effect of saffron oral capsule on anxiety and quality of sleep of diabetic patients in a tertiary healthcare facility in southeastern Iran: A quasi-experimental study

Cited by 11 publications

References 8 publications

Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis

Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis

The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial

Therapeutic potential of hypnotic herbal medicines: A comprehensive review

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