Effect of S-adenosyl-L-methionine on brain muscarinic receptors of aged rats

Muccioli, Giampiero; Scordamaglia, Antonella; Bertacco, S.; Carlo, R. Di

doi:10.1016/0922-4106(92)90007-i

Cited by 37 publications

(10 citation statements)

References 42 publications

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“…Treatment of aged rats for 30 days with SAMe restored the number of muscarinic receptors in the striatum and hippocampus to levels found in the same areas from young animals. Also the in vitro addition of SAMe to hippocampal membranes from aged rats resulted in a significant increase in the number of muscarinic binding sites ( Muccioli et al ., 1992 ). It has been suggested that these effects are due to an increase in the fluidity of neuronal membranes by stimulated phospholipid synthesis and methylation.…”

Section: Discussionmentioning

confidence: 99%

Influence of S‐adenosyl‐L‐methionine on chronic mild stress‐induced anhedonia in castrated rats

Benelli

Filaferro

Bertolini

et al. 1999

British J Pharmacology

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1. S-adenosyl-L-methionine (SAMe) is the most important methyl donor in the brain and is essential for polyamine synthesis. Methyl group deficiency in the brain has been implicated in depression; on the other hand, polyamines enhance phosphorylation processes, and phosphorylation of functional proteins in neurons in involved in the therapeutic mechanisms of antidepressants. 2. The effect of SAMe in an animal model of 'depression', the chronic mild stress-induced anhedonia, was studied using long-term castrated male and female Lister hooded rats. 3. Chronic daily exposure to an unpredictable sequence of mild stressors produced, within 3 weeks, a significant reduction of the consumption of a sucrose solution. SAMe (100, 200 or 300 mg kg-1 daily i.m.) while having no influence on sucrose intake in non-stressed animals, dose-dependently reinstated sucrose consumption within the first week of treatment, both in male and in female stressed rats. Imipramine (10 mg kg-1 daily i.p.) produced a similar effect after a 3 week treatment. 4. Similarly, a palatable food reward-induced place preference conditioning was developed in SAMe (200 or 300 mg kg-1 daily i.m.)--and in imipramine (10 mg kg-1 daily i.p.)--treated chronically stressed animals (males and females), whilst it could not be obtained in vehicle-treated rats. 5. Moreover, the same doses of SAMe (but not of imipramine) restored the exploratory activity and curiosity for the environment (rearing), in the open-field test. 6. While imipramine caused a blockade of the growth throughout the treatment, SAMe produced only a transient growth arrest during the first week of treatment. 7. These results show that SAMe reverses an experimental condition of 'depression-like' behaviour in rats, the effect being more rapid and complete than that of imipramine, and without apparent side effects.

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Section: Discussionmentioning

confidence: 99%

Influence of S‐adenosyl‐L‐methionine on chronic mild stress‐induced anhedonia in castrated rats

Benelli

Filaferro

Bertolini

et al. 1999

British J Pharmacology

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“…In fact, enhancement of phospholipid methylation has been shown to increase membrane fluidity, leading to an increase in the lateral movement of the beta-adrenergic receptor and more efficient coupling with adenylate cyclase in rat reticulocytes [73]. In a similar fashion, treatment with SAMe has resulted in an in vitro increase in rat brain muscarinic [74,75] and prolactin receptor binding [76]. Thus, it is possible that low folate levels may lead to a disruption in the one-carbon cycle metabolism resulting in abnormally low SAMe levels.…”

Section: Possible Antidepressant Mechanisms Of S-adenosyl-methioninementioning

confidence: 91%

S-adenosyl-methionine in depression: A comprehensive review of the literature

Papakostas

Alpert²,

Fava³

2003

Curr Psychiatry Rep

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As many as 29% to 46% of patients with major depressive disorder (MDD) show only partial or no response to an adequate course of an antidepressant. The current practice is to increase the dose, switch to another antidepressant, or to combine the initial antidepressant with an antidepressant of a different class or a non-antidepressant agent. A growing number of studies have also been directed toward exploring the potential use of augmenting traditional antidepressants with nonpharmaceutic supplements, or even using such supplements as monotherapy for depression. S-adenosyl-methionine (SAMe) is one such compound. Compared with many other nonpharmaceutic supplements, SAMe has been extensively studied, and impressive literature extending back three decades suggests the antidepressant efficacy of SAMe. In the present work, the authors summarize the literature, focusing on the potential role of SAMe and its precursors in the pathophysiology of MDD, followed by a review of studies examining the use of SAMe for the treatment of MDD. Finally, the authors propose a model that would explain the actions of SAMe in the central nervous system.

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“…Two mechanisms have been proposed; the stimulatory effect on monoamine transmitters or alternatively increased or restored membrane phospholipids methylation 83 . SAMe, through its activity as a methyl donor, has the ability to increase the fluidity of cell membranes by stimulating phospholipids methylation 99 . The effect of SAMe, on receptor systems is interesting because the evidence suggests that age‐related changes in the membrane environment may result in increased membrane viscosity and thus membrane dysfunction 100 …”

Section: Managementmentioning

confidence: 99%

“…83 SAMe, through its activity as a methyl donor, has the ability to increase the fluidity of cell membranes by stimulating phospholipids methylation. 99 The effect of SAMe, on receptor systems is interesting because the evidence suggests that age-related changes in the membrane environment may result in increased membrane viscosity and thus membrane dysfunction. 100 St John' s Wort is an herbal extract derived from the plant Hypericum perforatum.…”

Section: Adjunctive Nutritional Regimensmentioning

confidence: 99%

Depression: Does nutrition have an adjunctive treatment role?

Völker

Ng²

2006

Nutrition & Dietetics

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Depression is a serious illness, affecting more than one million Australians each year. It causes significant morbidity and is a major risk factor for deliberate self‐harm and suicide. Depression was traditionally viewed as a personality weakness, for which few treatment options were available. The simplistic view that depression is a personality weakness has changed in recent times. Depression is now widely recognised as a mood disorder with underlying biological (biochemical and genetic) and psychosocial causes and as such is responsive to a number of different treatments. The aim of the present paper is to review the literature related to dietary manipulation and how manipulation may assist in treating this illness. Evidence reviewed supports a potential therapeutic benefit of n‐3 polyunsaturated fatty acids for the alleviation of negative symptoms associated with depression. Omega‐3 polyunsaturated fatty acids, optimal omega balance, folate, tryptophan, vitamin B6, B12, S‐adenosyl‐L‐methionine and Hypericum perforatum may all serve as adjuncts to psychosocial and pharmacological therapies, with positive implications for long‐term prognosis.

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Effect of S-adenosyl-L-methionine on brain muscarinic receptors of aged rats

Cited by 37 publications

References 42 publications

Influence of S‐adenosyl‐L‐methionine on chronic mild stress‐induced anhedonia in castrated rats

Influence of S‐adenosyl‐L‐methionine on chronic mild stress‐induced anhedonia in castrated rats

S-adenosyl-methionine in depression: A comprehensive review of the literature

Depression: Does nutrition have an adjunctive treatment role?

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