Effect of rumen-protected choline and methionine on physiological and metabolic disorders and reproductive indices of dairy cows

Ardalan, M.; Rezayazdi, K.; Dehghan-Banadaky, M.

doi:10.1111/j.1439-0396.2009.00966.x

Cited by 35 publications

(41 citation statements)

References 25 publications

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“…In this sense, methionine supplementation before and around conception seems to be a promising tool for improving reproductive performance in lactating dairy cattle [18]. Previous studies in ruminants have indicated that a methionine-deficient diet provided to the dam prior to and for the first six days after conception can produce substantial changes in the offspring such as elevated blood pressure, insulin resistance, and altered immune response [19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Maternal Methionine Supplementation on the Transcriptome of Bovine Preimplantation Embryos

et al. 2013

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Maternal nutrition exclusively during the periconceptional period can induce remarkable effects on both oocyte maturation and early embryo development, which in turn can have lifelong consequences. The objective of this study was to evaluate the effect of maternal methionine supplementation on the transcriptome of bovine preimplantation embryos. Holstein cows were randomly assigned to one of two treatments differing in level of dietary methionine (1.89 Met vs. 2.43 Met % of metabolizable protein) from calving until embryo flushing. High quality preimplantation embryos from individual cows were pooled and then analyzed by RNA sequencing. Remarkably, a subtle difference in methionine supplementation in maternal diet was sufficient to cause significant changes in the transcriptome of the embryos. A total of 276 genes out of 10,662 showed differential expression between treatments (FDR <0.10). Interestingly, several of the most significant genes are related to embryonic development (e.g., VIM, IFI6, BCL2A1, and TBX15) and immune response (e.g., NKG7, TYROBP, SLAMF7, LCP1, and BLA-DQB). Likewise, gene set enrichment analysis revealed that several Gene Ontology terms, InterPro entries, and KEGG pathways were enriched (FDR <0.05) with differentially expressed genes involved in embryo development and immune system. The expression of most genes was decreased by maternal methionine supplementation, consistent with reduced transcription of genes with increased methylation of specific genes by increased methionine. Overall, our findings provide evidence that supplementing methionine to dams prior to conception and during the preimplantation period can modulate gene expression in bovine blastocysts. The ramifications of the observed gene expression changes for subsequent development of the pregnancy and physiology of the offspring warrant further investigation in future studies.

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Section: Introductionmentioning

confidence: 99%

Effect of Maternal Methionine Supplementation on the Transcriptome of Bovine Preimplantation Embryos

et al. 2013

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“…Rumen-protected choline (RPC) supplementation to both transition and early lactating dairy cows, usually provided as choline chloride coated with hydrogenated oils (Pinotti et al, 2002), has been demonstrated to improve milk production (Erdman and Sharma, 1991;Pinotti et al, 2003;Ardalan et al, 2010) and the metabolism of lipids and methyl groups (Piepenbrink and Overton, 2003;Baldi and Pinotti, 2006). Moreover, supplemental choline may improve the transport of lipids in the blood, thus reducing the risk of fatty liver disease and ketosis in periparturient dairy cows, as choline is an essential component of the phospholipids that are at the core of the structure of lipoproteins (Pinotti et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Lecithin: a by-product of biodiesel production and a source of choline for dairy cows

Marchesini

Segato

Stefani

et al. 2012

Italian Journal of Animal Science

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The aim of the present study was to compare soy lecithins (L), a by-product of the biodiesel production process, with choline chloride microencapsulated with hydrogenated vegetable oils (C), to verify their effects on dry matter intake, milk yield, milk quality traits, milk choline and haematological profile of dairy cows. A total of 12 mid-lactating Holstein Friesian cows were assigned to one of two experimental groups and fed according to cross-over design (2 diets x 2 periods). Diets were isoenergetic, isofibrous and isonitrogenous and had the same content of choline. Dry matter intake, milk yield and the 3.5% fat-corrected milk (FCM) were not affected by the diet. The milk choline content and the milk quality did not differ between treatments, with the exception of milk fat (P<0.05) and urea (P<0.01), which resulted lower for the L-group. Milk fat, protein and choline yields remained unaffected. With regard to the haematological profile, all of the parameters fell within the physiological range of lactating dairy cows, and the only difference was represented by the lower urea level of the L fed cows (P<0.01), that could be explained by a better N metabolic efficiency. Results indicated that soy lecithins can be used as an available source of choline in midlactating dairy cows.

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“…Supplementing RPM to the diet of dairy goats increased ECM (Flores et al 2009). Moreover, Ardalan et al (2010) and Soltan et al (2012) suggest that the increased ECM suggests that RPM can positively impact milk energy output when early-lactation curve peaks and drops. No effect of RPM supplementation was reported on ECM of dairy cows (Girard et al 2005).…”

Section: Milk Yield and Compositionmentioning

confidence: 99%

Effect of rumen-protected methionine on production and composition of early lactating Shami goats milk and growth performance of their kids

Al‐Qaisi

Titi

2014

Arch. Anim. Breed.

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This study was conducted at the Agricultural Research Station of the University of Jordan in the Jordan valley to evaluate the effect of supplementing rumen-protected methionine to early lactating Shami goats on milk production, composition, fatty acid profile, and growth performance of their kids. Twenty-four fresh lactating Shami goats were randomly assigned into three dietary treatment groups (eight each) in a completely randomized design. Diets were a control with no supplements or supplemented with either 2.5, or 5.0 g/head/d rumenprotected methionine. The experiment started exactly after kidding and lasted for 60 days thereafter. Production variables studied were milk production, milk composition, body weights, feed intake, kids weaning weight, and milk fatty acids.Daily milk production and energy corrected milk were not affected by protected me thionine supplementation. Milk Percentages of fat, protein, total solids, and casein were also not affected by protected methionine supplementation. Likewise, fat and protein yields were not different among dietary treatments of protected methionine. No differences in milk fatty acids composition were observed by supplementing rumen protected methionine in the experiment.Feed intake, feed to milk ratio, and final body weight of dams were not changed among treatments. No differences were observed in weaning weights, average daily gain, and milk to gain ratio of kids born to dams in the experiment regardless to sex of kids.In conclusion, results indicated that supplementing rumen protected methionine to dairy goats diet did not improve their milking performance, the composition of their milk, or growth performance of their kids.

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Effect of rumen-protected choline and methionine on physiological and metabolic disorders and reproductive indices of dairy cows

Cited by 35 publications

References 25 publications

Effect of Maternal Methionine Supplementation on the Transcriptome of Bovine Preimplantation Embryos

Effect of Maternal Methionine Supplementation on the Transcriptome of Bovine Preimplantation Embryos

Lecithin: a by-product of biodiesel production and a source of choline for dairy cows

Effect of rumen-protected methionine on production and composition of early lactating Shami goats milk and growth performance of their kids

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