Effect of royal jelly on testicular antioxidant enzymes activity, MDA level and spermatogenesis in rat experimental Varicocele model

Asadi, Nematollah; Kheradmand, Arash; Gholami, Mohammadreza; Saidi, Seyed Hojatolah; Mirhadi, S A

doi:10.1016/j.tice.2019.02.005

Cited by 28 publications

(25 citation statements)

References 43 publications

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“…In addition, our results demonstrated that VC-induced rats showed histological alteration in testes, such as impaired spermatogenesis and decreases in germ cells and vacuolization. Similar alterations have been observed in previous studies [7,31], showing that VC-induced testicular histological disruption is associated with oxidative stress and ER stress. Pretreatment of VC rats with SC preserved all histological changes, suggesting that SC has ameliorative effects on specific components of seminiferous epithelium and germ cells.…”

Section: Discussionsupporting

confidence: 91%

The Effect of Schisandra chinensis Baillon on Cross-Talk between Oxidative Stress, Endoplasmic Reticulum Stress, and Mitochondrial Signaling Pathway in Testes of Varicocele-Induced SD Rat

Karna

Choi

Kim

et al. 2019

IJMS

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Schisandra chinensis Baillon (SC) has been utilized for its antioxidants and anti-inflammatory activities in a broad variety of medical applications. However; SC uses for improving fertility in males and related disorders with proper scientific validation remain obscure. The present study aimed to investigate the effects of SC on varicocele (VC)-induced testicular dysfunction and the potential molecular mechanism associated with VC-induced germ cell apoptosis. The male Sprague–Dawley rats were equally divided into four groups consisting of 10 rats in a normal control group (CTR), a control group administered SC 200 mg/kg (SC 200), a varicocele-induced control group (VC), and a varicocele-induced group administered SC 200 mg/kg (VC + SC 200). Rats were administrated 200 mg/kg SC once daily for 28 days after induction of varicocele rats and sham controls. At the end of the treatment period, body and reproductive organ weight, sperm parameters, histopathological damages, proinflammatory cytokines, apoptosis markers, biomarkers of oxidative stress, endoplasmic reticulum (ER) stress, and steroidogenic acute regulatory protein (StAR) were evaluated. The effects of SC extract on human sperm motility were also analyzed. SC treatment reduces VC-induced testicular dysfunction by significantly increasing testicular weight, sperm count and sperm motility, serum testosterone level, Johnsen score, spermatogenic cell density, testicular superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase level, and steroidogenic acute regulatory protein (StAR) level. Furthermore, the effects of SC on malondialdehyde (MDA) level, reactive oxygen species (ROS)/reactive nitrogen species (RNS) level, apoptotic index, serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels, Glucose-regulated protein-78 (Grp 78), phosphorylated c-Jun-N-terminal kinase (p-JNK), phosphorylated inositol-requiring transmembrane kinase/endoribonuclease 1α (p-IRE1α), cleaved caspase 3, and Bax:Bcl2 in VC-induced rats were significantly decreased. Treatment with SC extracts also increased sperm motility in human sperm. Our findings suggest that the SC ameliorate testicular dysfunction in VC-induced rats via crosstalk between oxidative stress, ER stress, and mitochondrial-mediated testicular germ cell apoptosis signaling pathways. SC promotes spermatogenesis by upregulating abnormal sex hormones and decreasing proinflammatory cytokines (interleukin-6; TNF-α).

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Section: Discussionsupporting

confidence: 91%

The Effect of Schisandra chinensis Baillon on Cross-Talk between Oxidative Stress, Endoplasmic Reticulum Stress, and Mitochondrial Signaling Pathway in Testes of Varicocele-Induced SD Rat

Karna

Choi

Kim

et al. 2019

IJMS

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“…Considering its potent antioxidant activity, major components of the RJ are flavonoids and phenolic compounds (Yang et al, 2019;Šedivá et al, 2018;Kocot et al, 2018). In recent years, studies have motivated on the antimicrobial (Coutinho et al, 2018;Park et al, 2019), anti-inflammatory (Yang et al, 2018), anti-diabetic (Khazaei et al, 2018), anti-oxidant (Danis et al, 1994;Asadi et al, 2019;Gu et al, 2018), anti-tumor (Filipič et al, 2015) and anti-aging (Park et al, 2012) activities of RJ from different origins. The physical properties and chemical composition of the bee products vary with the genotype of the bees according to the flora species and climatic conditions and this affects the anticancer, antioxidant and antimicrobial activities of the bee products (Kocot et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Bingöl Arı Sütünün İçeriği ve Antimikrobiyal Aktivitesi

Bengü

Ayna

ÖZBOLAT

et al. 2020

Türk Tarım Ve Doğa Bilimleri Dergisi

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Royal jelly (RJ) is the special nutriment of the larva of queen honeybee (Apis mellifera) which is composed of several bioactive substances that include amino acids, proteins, carbohydrates, lipids, mineral salts, and vitamins. The content of RJ varies depending on genotype of the bees according to the flora species and climatic conditions and this affects biological activities of RJ. In recent years, literature has perceived an exponential growth in amount of drug (antibiotic)-resistant pathogenic bacteria. The main reasons of growing antibiotic resistance might be credited to the abuse of the antibiotic usage demonstrating prominence of examining other choices other than the communal antibiotics, such as bee products), to avoid a additional build-up in antibiotic resistance. To our knowledge, chemical content and antimicrobial activity of Bingol RJ (BRJ) has not been investigated to date. Therefore, the purpose of this study was to study composition and antimicrobial activities of BRJ. The results demonstrated that BRJ contains major flavonoids and phenolics such as apigenin, quercetin, naringenin, gallic acid, caffeic acid that contribute antimicrobial and antioxidant properties of BRJ. We have also shown that there are some middle and short chain fatty acids that include Linoleic acid and Propionic acid. BRJ also contain majority of trace elements and mineral. In addition to chemical content, antimicrobial activity of BRJ was also investigated towards pathogens. BRJ showed antimicrobial activity against Salmonella typhimurium (8.64 mm), Escherichia coli (9.1 mm) and Staphylococcus aureus (10.73 mm).

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“…This advantage is perhaps because of the existence of MRJPs in the RJ (Park et al, 2019). These properties supported the use of RJ as a well-known dietary supplement and different pharmaceuticals related to fertility disorders in human and animals (Asadi et al, 2019;Azad et al, 2018;Maghsoudlou et al, 2019;Zhang et al, 2019). MRJP substances have a strong antioxidant ability because of the capability of scavenging free radical by their properties of metal chelation (Park et al, 2019).…”

Section: Minerals and Vitaminsmentioning

confidence: 97%

“…In summary, this substantial enhancement in the motility of frozen-thawed sperm may be due to the collective influences of the chemical composition of the amino acids and the noteworthy antioxidant capacity of the RJ (Bărnuţiu et al, 2011). Furthermore, RJ is rich in calcium ions that promote sperm motility by limiting the capacity of sperm cells (Howe, Dimick, & Benton, 1985;Kodai et al, 2007 (Asadi et al, 2019;Park et al, 2019). Likewise, Khadr et al (2015) pointed out that oral administration of 200 mg RJ/kg every other day for 6 weeks produced higher progressive motility percentage (91.0 ± 0.9) in pre-pubertal buck rabbits compared with the control group (70.0 ± 1.1).…”

Section: Sperm Motility Parametersmentioning

confidence: 99%

“…The RJ protects testis of rats against the negative influences of oxidative stress in the reproductive tract. This defence may be because of the suppressive influences of free radical synthesis and lipid peroxidation, and also the improvement of antioxidant enzyme formation (Asadi et al, 2019). function and disrupts the hormonal balance (Yang et al, 2012).…”

Section: Minerals and Vitaminsmentioning

confidence: 99%

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Useful impacts of royal jelly on reproductive sides, fertility rate and sperm traits of animals

Abdelnour

El‐Hack

Alagawany

et al. 2020

Animal Physiology Nutrition

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Royal jelly (RJ) is one of the furthermost valuable curative products mentioned by natural medicine scientists due to its promising medical and nutritional purposes. It possesses many impacts, including antioxidants, antimicrobial, antitumor, antiinflammatory and immunomodulatory functions in human and animal that benefit How to cite this article: Abdelnour SA, Abd El-Hack ME, Alagawany M, et al. Useful impacts of royal jelly on reproductive sides, fertility rate and sperm traits of animals.

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Effect of royal jelly on testicular antioxidant enzymes activity, MDA level and spermatogenesis in rat experimental Varicocele model

Cited by 28 publications

References 43 publications

The Effect of Schisandra chinensis Baillon on Cross-Talk between Oxidative Stress, Endoplasmic Reticulum Stress, and Mitochondrial Signaling Pathway in Testes of Varicocele-Induced SD Rat

The Effect of Schisandra chinensis Baillon on Cross-Talk between Oxidative Stress, Endoplasmic Reticulum Stress, and Mitochondrial Signaling Pathway in Testes of Varicocele-Induced SD Rat

Bingöl Arı Sütünün İçeriği ve Antimikrobiyal Aktivitesi

Useful impacts of royal jelly on reproductive sides, fertility rate and sperm traits of animals

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