Effect of royal jelly on longevity and memory-related traits of Apis mellifera workers

Shi, Jingliang; Liao, Chunhua; Wang, Zilong; Wu, Xiaobo

doi:10.1016/j.aspen.2018.11.003

Cited by 14 publications

(8 citation statements)

References 16 publications

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“…Moreover, RJ has antioxidants with the potential of reducing the risk of cancer, high blood pressure, diabetes, and cardiovascular diseases [94,110,111]. RJ also affects the morphological characters, growth, learning, size, and shape variations in various creatures, such as honeybees, mice, and humans [112].…”

Section: Biological Activity Of Rjmentioning

confidence: 99%

“…Memory impairment and depression-like behaviors in ovariectomized rats are recovered to the levels of sham-operated rats by RJ administration [171]. RJ administration has the potential to consolidate the learning, memory abilities, and longevity of honeybees [112], and the intake of RJ has the potential to ameliorate cognitive deficits [103]. RJ ingestion is effective on neurological disorders, such as Alzheimer's disease in postmenopausal patients, via decreasing cholesterol and amyloid-beta deposition, increasing cholinergic response, estrogen level, and also improving the blood-brain barrier and autonomic nervous systems [102].…”

Section: Neuroprotective Effectmentioning

confidence: 99%

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New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Ahmad

Campos

Fratini

et al. 2020

IJMS

158

134

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Royal jelly (RJ) is a yellowish-white and acidic secretion of hypopharyngeal and mandibular glands of nurse bees used to feed young worker larvae during the first three days and the entire life of queen bees. RJ is one of the most appreciated and valued natural product which has been mainly used in traditional medicines, health foods, and cosmetics for a long time in different parts of the world. It is also the most studied bee product, aimed at unravelling its bioactivities, such as antimicrobial, antioxidant, anti-aging, immunomodulatory, and general tonic action against laboratory animals, microbial organisms, farm animals, and clinical trials. It is commonly used to supplement various diseases, including cancer, diabetes, cardiovascular, and Alzheimer’s disease. Here, we highlight the recent research advances on the main bioactive compounds of RJ, such as proteins, peptides, fatty acids, and phenolics, for a comprehensive understanding of the biochemistry, biological, and pharmaceutical responses to human health promotion and life benefits. This is potentially important to gain novel insight into the biological and pharmaceutical properties of RJ.

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Section: Biological Activity Of Rjmentioning

confidence: 99%

Section: Neuroprotective Effectmentioning

confidence: 99%

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Ahmad

Campos

Fratini

et al. 2020

IJMS

158

134

View full text Add to dashboard Cite

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“…Real-time RT-PCR and HPLC-ECD analysis denoted that augmentation of fertility (ovarian development) in bee workers by RJ is the result of enhancement of brain levels of tyrosine, dopamine, and tyramine by RJ [61], as well as activation of epidermal growth factor receptor ( EGFR ), which increases the production of the juvenile hormone, titre, known to regulate growth [41]. RJ also improves the memory of bee workers [62] and increases their survival [15,41,56,62,63], owing to its high Ach concentration [56], MRJP1 content of royalactin [41], MRJPs 2, 3, and 5 [25], and a water soluble RJ protein extracted by precipitation with 60% ammonium sulfate (RJP 60 ) [15].…”

Section: Healthspan and Longevity Effects Of Rj In Various Speciesmentioning

confidence: 99%

Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans

Kunugi

Ali

2019

IJMS

143

154

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Aging is a natural phenomenon that occurs in all living organisms. In humans, aging is associated with lowered overall functioning and increased mortality out of the risk for various age-related diseases. Hence, researchers are pushed to find effective natural interventions that can promote healthy aging and extend lifespan. Royal jelly (RJ) is a natural product that is fed to bee queens throughout their entire life. Thanks to RJ, bee queens enjoy an excellent reproductive function and lengthened lifespan compared with bee workers, despite the fact that they have the same genome. This review aimed to investigate the effect of RJ and/or its components on lifespan/healthspan in various species by evaluating the most relevant studies. Moreover, we briefly discussed the positive effects of RJ on health maintenance and age-related disorders in humans. Whenever possible, we explored the metabolic, molecular, and cellular mechanisms through which RJ can modulate age-related mechanisms to extend lifespan. RJ and its ingredients—proteins and their derivatives e.g., royalactin; lipids e.g., 10-hydroxydecenoic acid; and vitamins e.g., pantothenic acid—improved healthspan and extended lifespan in worker honeybees Apis mellifera, Drosophila Melanogaster flies, Gryllus bimaculatus crickets, silkworms, Caenorhabditis elegans nematodes, and mice. The longevity effect was attained via various mechanisms: downregulation of insulin-like growth factors and targeting of rapamycin, upregulation of the epidermal growth factor signaling, dietary restriction, and enhancement of antioxidative capacity. RJ and its protein and lipid ingredients have the potential to extend lifespan in various creatures and prevent senescence of human tissues in cell cultures. These findings pave the way to inventing specific RJ anti-aging drugs. However, much work is needed to understand the effect of RJ interactions with microbiome, diet, activity level, gender, and other genetic variation factors that affect healthspan and longevity.

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“…Various factors influence the quality of RJ by affecting its ingredients and their activity. For instance, feeding bees with sugars causes significant alterations in the amounts and structure of vital constituents of RJ such as amino acids (e.g., tryptophan and lysine), derivatives of amino acids (e.g., pyroglutamic acid), amines (e.g., cadaverine), carbohydrates, and vitamins [ 103 ]. Of importance, RJ should be stored in a frozen state in order to retain its biological properties.…”

Section: Royal Jelly Its Ingredients and Pharmacological Propertimentioning

confidence: 99%

“…From another standpoint, evolving knowledge highlights an important role of dopamine and its D2-like dopamine receptor gene (AmDOP3) in learning and memory via the homovanillyl alcohol target dopamine pathways in the brain [ 150 ]. RJ contains tryptophan and tyrosine, the precursors of serotonin and dopamine [ 63 , 103 , 151 ]. Treating experimental models with RJ and tyrosine significantly increases brain levels of dopamine and its metabolites [ 152 , 153 ].…”

Section: Mechanisms Underlying Effects Of Rj On Cognition and Ad-rmentioning

confidence: 99%

Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A Review

Ali

2020

Antioxidants

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The astronomical increase of the world’s aged population is associated with the increased prevalence of neurodegenerative diseases, heightened disability, and extremely high costs of care. Alzheimer’s Disease (AD) is a widespread, age-related, multifactorial neurodegenerative disease that has enormous social and financial drawbacks worldwide. The unsatisfactory outcomes of available AD pharmacotherapy necessitate the search for alternative natural resources that can target various the underlying mechanisms of AD pathology and reduce disease occurrence and/or progression. Royal jelly (RJ) is the main food of bee queens; it contributes to their fertility, long lifespan, and memory performance. It represents a potent nutraceutical with various pharmacological properties, and has been used in a number of preclinical studies to target AD and age-related cognitive deterioration. To understand the mechanisms through which RJ affects cognitive performance both in natural aging and AD, we reviewed the literature, elaborating on the metabolic, molecular, and cellular mechanisms that mediate its anti-AD effects. Preclinical findings revealed that RJ acts as a multidomain cognitive enhancer that can restore cognitive performance in aged and AD models. It promotes brain cell survival and function by targeting multiple adversities in the neuronal microenvironment such as inflammation, oxidative stress, mitochondrial alterations, impaired proteostasis, amyloid-β toxicity, Ca excitotoxicity, and bioenergetic challenges. Human trials using RJ in AD are limited in quantity and quality. Here, the limitations of RJ-based treatment strategies are discussed, and directions for future studies examining the effect of RJ in cognitively impaired subjects are noted.

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Effect of royal jelly on longevity and memory-related traits of Apis mellifera workers

Cited by 14 publications

References 16 publications

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans

Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A Review

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