Effect of route of administration in the micronucleus test with potassium bromate

Nakajima, Masahiro; Kitazawa, Michiyo; Oba, Kousuke; Kitagawa, Yuichi; Toyoda, Yoshiko

doi:10.1016/0165-1218(89)90095-5

Cited by 23 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is notable that MN levels for relatively short-lived (2-3 days) PCEs reflecting acute exposure effects also reveal differences between experiments (i.e., higher maximum MN induction levels in the 8-week exposure trial). The general patterns of dose-dependent, significant increases in blood cell MN described here after chronic exposure to KBrO 3 are similar to, although lower in magnitude than, those reported earlier after acute or subacute bromate exposure of mice [Hayashi et al, 1988;Nakajima et al, 1989]. The data from the present study clearly indicate that chronic exposure to KBrO 3 under the described conditions damages chromosomes; however, they do not define a consistent relationship between genotoxic and carcinogenic properties over the dose range used.…”

Section: Resultssupporting

confidence: 57%

See 1 more Smart Citation

Erythrocyte and spermatid micronucleus analyses in mice chronically exposed to potassium bromate in drinking water

Allen

Collins

Lori

et al. 2000

Environ. Mol. Mutagen.

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 57%

“…It is well established that levels of inducible chromosome damage can vary with the route and duration of chemical exposure [Hayashi et al, 1989;Witt et al, 1999]. Studies with KBrO 3 have given mixed results regarding route-specific differences in levels of induced chromosome damage [Hayashi et al, 1989;Nakajima et al, 1989].…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte and spermatid micronucleus analyses in mice chronically exposed to potassium bromate in drinking water

Allen

Collins

Lori

et al. 2000

Environ. Mol. Mutagen.

View full text Add to dashboard Cite

“…In a 1994 assessment of potassium bromate and sodium bromate, the Cosmetic Ingredient Review (CIR) Expert Panel stated that these ingredients may be used in cosmetic permanent wave formulations at concentrations not to exceed 10.17%, measured as sodium bromate. 1 The Expert Panel reviewed newly available studies since that assessment, along with updated information regarding types and concentrations of use 2…”

Section: Resultsmentioning

confidence: 99%

Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

Andersen¹

2011

Int J Toxicol

View full text Add to dashboard Cite

This Annual Review of Cosmetic Ingredient Safety Assessments updates and affirms the findings of the Cosmetic Ingredient Review (CIR) Expert Panel's assessment of almost 30 compounds used in cosmetic ingredients. The review also summarizes new findings from epidemiology studies of hair dyes. The CIR Expert Panel's re-review process is intended to uncover any new data since the last safety assessment. In some cases, newly available data are largely redundant compared with the data available in the original safety assessment. In other cases, new data present new safety issues. If after considering the newly available information, the CIR Expert Panel decides to not reopen a safety assessment, this finding, along with any background material, is summarized and announced publicly. To assure that the scientific community is aware of any new information and the decision not to reopen, this Annual Review of Cosmetic Ingredient Safety Assessments is prepared. A list of reference sources is provided after each ingredient re-review summary that updates the available published literature and includes any unpublished data made available since the original safety assessment. The re-review also captures information on the industry's current practices of ingredient use, updating the data available in the earlier report. Although this material provides the opinion of the CIR Expert Panel regarding the new data described, it does not constitute a full safety review. The CIR Expert Panel has assessed the safety of over 2100 cosmetic ingredients since its inception in 1976. These safety assessments were published in the

show abstract

“…KBrO 3 is potentially genotoxic in bacterial mutation assays (1) and in chromosome aberration tests using a hamster cell line (1). In a micronucleus assay, KBrO 3 induced micronucleated polychromatic erythrocytes dose-dependently in male mice (2,3). KBrO 3 is a well-known renal carcinogen to rats, and also tumors in other organs have been observed after oral administration of KBrO 3 (4).…”

Section: Introductionmentioning

confidence: 99%

Requirement of Glutathione and Cysteine in Guanine-Specific Oxidation of DNA by Carcinogenic Potassium Bromate

Murata

Bansho

Inoue

et al. 2001

Chem. Res. Toxicol.

View full text Add to dashboard Cite

Potassium bromate (KBrO3), a food additive, induces renal-cell tumors in rats. KBrO3 induced 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodG) formation in human leukemia cell line HL-60 as well as in its H2O2-resistant clone, HP100, suggesting no involvement of H2O2. Depletion of GSH by buthionine sulfoximine (BSO) had a little inhibitory effect on KBrO3-induced 8-oxodG formation. However, the amount of 8-oxodG was still significantly higher than that in control, suggesting that intracellular Cys can affect KBrO3 to oxidize DNA, when GSH decreased. KBrO3 caused 8-oxodG in isolated DNA in the presence of GSH (tripeptide; gamma-GluCysGly), gamma-GluCys, CysGly, or Cys. Methional completely inhibited 8-oxodG formation induced by KBrO3 plus GSH, but typical hydroxyl radical scavengers, SOD and catalase, had little or no inhibitory effects. When bromine solution (BrO(-)) was used instead of BrO3(-), similar scavenger effects were observed. Experiments with 32P-labeled DNA fragments obtained from the human p53 tumor suppressor gene and the c-Ha-ras-1 protooncogene suggested that KBrO3 induced 8-oxodG formation at 5'-site guanine of GG and GGG sequences of double-stranded DNA in the presence of GSH and that treatment of formamidopyrimidine-DNA glycosylase led to chain cleavages at the guanine residues. ESR spin-trapping studies showed that 1:2:2:1 quartet DMPO (5,5-dimethyl-1-pyrroline N-oxide) spectrum similar to DMPO/hydroxy radical (*OH) adduct, but the signals were not inhibited by ethanol. Therefore, the signal seemed not to be due to *OH but byproduct due to oxidation of DMPO by the reactive species. The signals were suppressed by the addition of dGMP, but not by other mononucleotides, suggesting the specific reactivity with guanine. On the basis of our results and previous literature, it is speculated that reduction of KBrO3 by SH compounds in renal proximal tubular cells yields bromine oxides and bromine radicals, which are the reactive species that cause guanine oxidation, leading to renal carcinogenesis of KBrO3.

show abstract

Effect of route of administration in the micronucleus test with potassium bromate

Cited by 23 publications

References 6 publications

Erythrocyte and spermatid micronucleus analyses in mice chronically exposed to potassium bromate in drinking water

Erythrocyte and spermatid micronucleus analyses in mice chronically exposed to potassium bromate in drinking water

Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

Requirement of Glutathione and Cysteine in Guanine-Specific Oxidation of DNA by Carcinogenic Potassium Bromate

Contact Info

Product

Resources

About