Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: A high-resolution magnetic resonance imaging trial

Underhill, Hunter R.; Yuan, Chun; Zhao, Xue Qiao; Kraiss, Larry W.; Parker, Dennis L.; Saam, Tobias; Chu, Baocheng; Takaya, Norihide; Liu, Fei; Polissar, Nayak L.; Neradilek, Blažej; Raichlen, Joel S.; Cain, Valerie A.; Waterton, John C.; Hamar, Wendy; Hatsukami, Thomas S.

doi:10.1016/j.ahj.2007.11.018

Cited by 246 publications

(181 citation statements)

References 23 publications

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“…It has been established (4) that the presence of certain features, such as fibrous cap rupture, large lipid rich/necrotic core (LR/NC), and intraplaque hemorrhage (IPH) significantly increases the risk of cerebrovascular ischemic events (stroke and transient ischemic attacks). Beyond diagnostic and prognostic applications, carotid MRI has been widely used during recent years in clinical trials investigating the effect of lipid-lowering therapies (5,6). For such studies, MRI can deliver direct quantitative measures characterizing plaque size, geometry, and tissue composition, which are of critical interest as surrogate endpoints reflecting the effect of intervention on its primary target.…”

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confidence: 99%

Scan‐rescan reproducibility of carotid atherosclerotic plaque morphology and tissue composition measurements using multicontrast MRI at 3T

Yarnykh

Hatsukami

et al. 2009

Magnetic Resonance Imaging

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Purpose: To evaluate interscan reproducibility of both vessel morphology and tissue composition measurements of carotid atherosclerosis using a fast, optimized, 3T multicontrast protocol. Materials and Methods:A total of 20 patients with carotid stenosis >15% identified by duplex ultrasound were recruited for two independent 3T MRI (Philips) scans within one month. A multicontrast protocol including five MR sequences was applied: TOF, T1-/T2-/PD-weighted and magnetization-prepared rapid acquisition gradientecho (MP-RAGE). Carotid artery morphology (wall volume, lumen volume, total vessel volume, normalized wall index, and mean/maximum wall thickness) and plaque component size (lipid rich/necrotic core, calcification, and hemorrhage) were measured over two time points.Results: After exclusion of images with poor image quality, 257 matched locations from 18 subjects were available for analysis. For the quantitative carotid morphology measurements, coefficient of variation (CV) ranged from 2% to 15% and intraclass correlation coefficient (ICC) ranged from 0.87 to 0.99. Except for maximum wall thickness (ICC ¼ 0.87), all ICC were larger than 0.90. For the quantitative plaque composition measurements, the ICC of the volume and relative content of lipid rich/necrotic core and calcification were larger than 0.90 with CV ranging from 22% to 32%. Conclusion:The results from the multicontrast high-resolution 3T MR study show high reliability for carotid morphology and plaque component measurements. 3T MRI is a reliable tool for longitudinal clinical trials, with shorter scan time compared to 1.5T.

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confidence: 99%

Scan‐rescan reproducibility of carotid atherosclerotic plaque morphology and tissue composition measurements using multicontrast MRI at 3T

Yarnykh

Hatsukami

et al. 2009

Magnetic Resonance Imaging

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“…35 Previous studies have shown that the LRNC of carotid atherosclerosis regresses after treatment with lipid-lowering drugs. 36 For symptomatic patients, therefore, early detection of LRNC size by using accurate MR imaging techniques and receiving systemic lipid-lowering therapy may be helpful for prevention of recurrent stroke.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Carotid Atherosclerotic Plaque Characteristics by High-Resolution Black-Blood MR Imaging between Patients with First-Time and Recurrent Acute Ischemic Stroke

Liu

Zhao

Cao

et al. 2012

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: It has been shown that patients with a first ischemic stroke are at high risk of developing recurrent stroke due to carotid atherosclerotic plaque rupture. However, no one has defined the difference in plaques between initial and recurrent stroke. This study sought to investigate the characteristics of carotid plaque between patients with first-time and recurrent acute ischemic stroke by using MR imaging.

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“…4 In the ORION trial, individuals who were on very high-intensity therapy, 40-80 mg of rosuvastatin daily, experienced no change in carotid plaque volume. Rather, in all these individuals with a lipid-rich necrotic core at baseline, there was a mean decrease of 41% in the proportion of the vessel wall composed of the lipid-rich necrotic core.…”

Section: Cimt or Ldl-c?mentioning

confidence: 99%

The Implications of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression Trial: A Return to First Principles

Musunuru¹,

Blumenthal²

2008

Clinical Cardiology

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To outward appearances, the publication of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) trial has led to a monolithic backlash against the use of ezetimibe by cardiologists for the treatment of hyperlipidemia. Rather than be swayed by popular opinion, we should each put the results of ENHANCE into context and ask the questions: should I put my trust in an imaging surrogate or in low-density lipoprotein (LDL) cholesterol (LDL-C), and how do the safety and efficacy of ezetimibe compare with other nonstatin lipid-lowering agents?

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Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: A high-resolution magnetic resonance imaging trial

Cited by 246 publications

References 23 publications

Scan‐rescan reproducibility of carotid atherosclerotic plaque morphology and tissue composition measurements using multicontrast MRI at 3T

Scan‐rescan reproducibility of carotid atherosclerotic plaque morphology and tissue composition measurements using multicontrast MRI at 3T

Comparison of Carotid Atherosclerotic Plaque Characteristics by High-Resolution Black-Blood MR Imaging between Patients with First-Time and Recurrent Acute Ischemic Stroke

The Implications of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression Trial: A Return to First Principles

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