Effect of root canal medications on maturation and calcification of root canal dentin’ hydroxyapatite

Zeid, Sawsan Taha Hassan Abu; Khafagi, Monazah G.; Neel, Ensanya A. Abou

doi:10.1080/00387010.2015.1099109

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…Detectable TAP could be found deeper in the dentin (up to 350 µm) 28 days after application than was the case for residual CH, which was present at a shallower level [ 40 ]. A demineralizing effect has been detected and a collagen-rich matrix has been found to form on the surface of radicular dentin in contact with TAP and DAP [ 6 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…CHX did not seem to affect the retention of either MTA or BA. In a recent study, CHX showed a lack of demineralizing or solving effect on the mineral or organic content of dentin [ 6 ]. Ari et al [ 53 ] showed that 0.2% CHX used as an irrigant was harmless to dentin microhardness and roughness.…”

Section: Discussionmentioning

confidence: 99%

“…Chlorhexidine (CHX) has been used in endodontics as an irrigant and an ICM. It has been proposed as an alternative to CH and antibiotics in REPs, as it shows similar antibacterial effects [ 4 ] and may have fewer adverse effects on dentin [ 5 6 ]. It has been used alone or in combination with CH [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Retention of BioAggregate and MTA as coronal plugs after intracanal medication for regenerative endodontic procedures: an ex vivo study

Amin

Gawdat

2018

Restor Dent Endod

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ObjectivesThis study compared the retention of BioAggregate (BA; Innovative BioCeramix) and mineral trioxide aggregate (MTA; Angelus) as coronal plugs after applying different intracanal medications (ICMs) used in regenerative endodontics.Materials and MethodsOne-hundred human maxillary central incisors were used. The canals were enlarged to a diameter of 1.7 mm. Specimens were divided into 5 groups (n = 20) according to the ICM used: calcium hydroxide (CH), 2% chlorhexidine (CHX), triple-antibiotic paste (TAP), double-antibiotic paste (DAP), and no ICM (control; CON). After 3 weeks of application, ICMs were removed and BA or MTA were placed as the plug material (n = 10). The push-out bond strength and the mode of failure were assessed. The data were analyzed using 2-way analysis of variance, the Tukey's test, and the χ2 test; p values < 0.05 indicated statistical significance.ResultsThe type of ICM and the type of plug material significantly affected bond strength (p < 0.01). Regardless of the type of ICM, BA showed a lower bond strength than MTA (p < 0.05). For MTA, CH showed a higher bond strength than CON, TAP and DAP; CHX showed a higher bond strength than DAP (p < 0.01). For BA, CH showed a higher bond strength than DAP (p < 0.05). The mode of failure was predominantly cohesive for BA (p < 0.05).ConclusionsMTA may show better retention than BA. The mode of bond failure with BA can be predominantly cohesive. BA retention may be less affected by ICM type than MTA retention.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Retention of BioAggregate and MTA as coronal plugs after intracanal medication for regenerative endodontic procedures: an ex vivo study

Amin

Gawdat

2018

Restor Dent Endod

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“…In this instance, EDTA is combined with sodium hypochlorite, which acts as a disinfectant. The concentration of EDTA in these solutions is between 17 and 25% [49][50][51][52][53][54][55][57][58][59][60]. When used in cosmetics it is 2% and the lowest dose reported to cause a toxic effect in animals while administered by injection was 750 mg/kg/day [61].…”

Section: Discussionmentioning

confidence: 99%

Dystrophic calcinosis: structural and morphological composition, and evaluation of ethylenediaminetetraacetic acid (‘EDTA’) for potential local treatment

Lee,

Green,

Marzec

et al. 2024

Arthritis Res Ther

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Background To perform a detailed morphological analysis of the inorganic portion of two different clinical presentations of calcium-based deposits retrieved from subjects with SSc and identify a chemical dissolution of these deposits suitable for clinical use. Methods Chemical analysis using Fourier Transform IR spectroscopy (‘FTIR’), Raman microscopy, Powder X-Ray Diffraction (‘PXRD’), and Transmission Electron Microscopy (‘TEM’) was undertaken of two distinct types of calcinosis deposits: paste and stone. Calcinosis sample titration with ethylenediaminetetraacetic acid (‘EDTA’) assessed the concentration at which the EDTA dissolved the calcinosis deposits in vitro. Results FTIR spectra of the samples displayed peaks characteristic of hydroxyapatite, where signals attributable to the phosphate and carbonate ions were all identified. Polymorph characterization using Raman spectra were identical to a hydroxyapatite reference while the PXRD and electron diffraction patterns conclusively identified the mineral present as hydroxyapatite. TEM analysis showed differences of morphology between the samples. Rounded particles from stone samples were up to a few micron in size, while needle-like crystals from paste samples reached up to 0.5 µm in length. Calcium phosphate deposits were effectively dissolved with 3% aqueous solutions of EDTA, in vitro. Complete dissolution of both types of deposit was achieved in approximately 30 min using a molar ratio of EDTA/HAp of ≈ 300. Conclusions Stone and paste calcium-based deposits both comprise hydroxyapatite, but the constituent crystals vary in size and morphology. Hydroxyapatite is the only crystalline polymorph present in the SSc-related calcinosis deposits. Hydroxyapatite can be dissolved in vitro using a dosage of EDTA considered safe for clinical application. Further research is required to establish the optimal medium to develop the medical product, determine the protocol for clinical application, and to assess the effectiveness of EDTA for local treatment of dystrophic calcinosis.

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Phase-resolved photoacoustic spectroscopy to monitor dental plaque on tooth enamel

Dias

Sales

Nakamura

et al. 2018

Spectroscopy Letters

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Effect of root canal medications on maturation and calcification of root canal dentin’ hydroxyapatite

Cited by 4 publications

References 32 publications

Retention of BioAggregate and MTA as coronal plugs after intracanal medication for regenerative endodontic procedures: an ex vivo study

Retention of BioAggregate and MTA as coronal plugs after intracanal medication for regenerative endodontic procedures: an ex vivo study

Dystrophic calcinosis: structural and morphological composition, and evaluation of ethylenediaminetetraacetic acid (‘EDTA’) for potential local treatment

Phase-resolved photoacoustic spectroscopy to monitor dental plaque on tooth enamel

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