Effect of rinsing with povidone–iodine on bacteraemia due to scaling: a randomized‐controlled trial

Cherry, Martin R; Daly, Christopher; Mitchell, David; Highfield, J. E.

doi:10.1111/j.1600-051x.2006.01025.x

Cited by 35 publications

(48 citation statements)

References 46 publications

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“…22,2009 ODONTOGENIC BACTEREMIA BEYOND ENDOCARDITIS 47 teremia." On all occasions, records were sorted according to relevance, and if it was deemed necessary, references cited in a given record were further analyzed.…”

Section: Search Strategymentioning

confidence: 99%

“…Various degrees of bacterial dissemination are associated with periodontal probing (27,28), scaling (22,68), root planing, and subgingival irrigation (5,77,106,141). The presence of inflammation in the periodontal site is an important contributory factor to bacterial dissemination, as shown by the increased incidence of bacteremia in subjects with periodontitis compared to those with gingivitis (where the degree of inflammation is considered less severe) and those with healthy periodontium (48).…”

Section: Periodontal Proceduresmentioning

confidence: 99%

“…Other contributory factors for the phenom-VOL. 22,2009 ODONTOGENIC BACTEREMIA BEYOND ENDOCARDITIS 55…”

Section: Tooth Extractionmentioning

confidence: 99%

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Microbiology of Odontogenic Bacteremia: beyond Endocarditis

et al. 2009

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SUMMARY The human gingival niche is a unique microbial habitat. In this habitat, biofilm organisms exist in harmony, attached to either enamel or cemental surfaces of the tooth as well as to the crevicular epithelium, subjacent to a rich vascular plexus underneath. Due to this extraordinary anatomical juxtaposition, plaque biofilm bacteria have a ready portal of ingress into the systemic circulation in both health and disease. Yet the frequency, magnitude, and etiology of bacteremias due to oral origin and the consequent end organ infections are not clear and have not recently been evaluated. In this comprehensive review, we address the available literature on triggering events, incidence, and diversity of odontogenic bacteremias. The nature of the infective agents and end organ infections (other than endocarditis) is also described, with an emphasis on the challenge of establishing the link between odontogenic infections and related systemic, focal infections.

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Section: Search Strategymentioning

confidence: 99%

Section: Periodontal Proceduresmentioning

confidence: 99%

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Microbiology of Odontogenic Bacteremia: beyond Endocarditis

et al. 2009

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“…Invasive dental procedures that traumatise the periodontium such as periodontal probing, scaling and root planing, subgingival irrigation, periodontal surgery, rubber dam placement, matrix band placement and extractions can allow microbes in the gingival sulcus/pocket to gain entry into the systemic circulation and cause bacteraemia , Sconyers et al 1973, Berger et al 1974, Baumgartner et al 1976, Forner et al 2006, Cherry et al 2007. It is thought that the more invasive and the longer the duration of the procedure, the greater the incidence of bacteraemia detected (Lockhart 2000).…”

Section: Oral Bacteraemiamentioning

confidence: 99%

“…The intensity of bacteraemia necessary to induce experimental infective endocarditis in animals is of the order of 1 x 10 6 to 1 x 10 7 colony forming units (CFU) per mL (Bahn et al 1978). A dentally associated bacteraemia in adult humans is usually of a low-grade intensity and of the order of <10 CFU per mL of blood , Forner et al 2006, Cherry et al 2007). …”

Section: Magnitude Of Bacteraemiamentioning

confidence: 99%

Bacteraemia due to dental flossing

Crasta

Daly

Mitchell

et al. 2009

J Clinic Periodontology

Self Cite

114

105

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Aims: The aims of this study were to (1) investigate the incidence of bacteraemia following flossing in subjects with chronic periodontitis or periodontal health; (2) identify the micro‐organisms in detected bacteraemias; and (3) identify any patient or clinical factors associated with such bacteraemia. Material and Methods: Baseline blood samples were obtained from 30 individuals with chronic periodontitis (17 M:13 F, 29–75 years) and 30 with periodontal health (17 M:13 F, 28–71 years) following a non‐invasive examination. Each subject's teeth were then flossed in a standardized manner and blood samples obtained 30 s and 10 min. after flossing cessation. Blood samples were cultured in a BACTEC™ system and positive samples subcultured for identification. Results: Forty per cent of periodontitis subjects and 41% of periodontally healthy subjects tested positive for bacteraemia following flossing. Viridans streptococci, which are commonly implicated in infective endocarditis (IE), were isolated from 19% of positive subjects and accounted for 35% of microbial isolates. Twenty per cent of subjects had a detectable bacteraemia at 10 min. post‐flossing. No patient or clinical factors were significantly associated with post‐flossing bacteraemia. Conclusions: Dental flossing can produce bacteraemia in periodontally healthy and periodontally diseased individuals at a rate comparable with that caused by some dental treatments for which antibiotic prophylaxis is given to prevent IE.

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Design and Synthesis of Novel Benzopyran‐2‐one Derivatives of Expected Antimicrobial Activity through DNA Gyrase‐B Inhibition

Hassan

Farag

Hegazy³

et al. 2008

Archiv der Pharmazie

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In an attempt to find a new class of antibacterial agents, we have synthesized thirty new coumarin (2H-benzopyran-2-one) analogues. These derivatives include substituted azetidin-2-ones (beta-lactam) 3a-f, pyrrolidin-2-ones 4a-f, 2H-1,3,4-oxadiazoles 5a-f, and thiazolidin-4-ones 6a-f attached to 4-phenyl-2H-benzopyran-2-one through an oxyacetamido or an oxymethyl bridge. The target compounds were synthesized starting from 2-oxo-4-phenyl-2H-benzo[b]pyran-7-yl-oxyacetic acid hydrazides 2a-f. The new compounds were evaluated as DNA gyrase-B inhibitors through molecular modeling and docking techniques using the Molsoft ICM 3.4-8C program. The synthesized compounds were also screened for antibacterial activity against four different species of Gram-positive and Gram-negative bacteria; as well as screening against C. albicans for antifungal activity. The molecular modeling data were in accordance with the antimicrobial screening results.

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Effect of rinsing with povidone–iodine on bacteraemia due to scaling: a randomized‐controlled trial

Abstract: Rinsing with 7.5% povidone-iodine reduced the incidence and magnitude of bacteraemia and eliminated viridans streptococci from such bacteraemia. Povidone-iodine rinsing may be helpful for ultrasonic scaling of gingivitis patients at risk of infective endocarditis.

Cited by 35 publications

References 46 publications

Microbiology of Odontogenic Bacteremia: beyond Endocarditis

Microbiology of Odontogenic Bacteremia: beyond Endocarditis

Bacteraemia due to dental flossing

Design and Synthesis of Novel Benzopyran‐2‐one Derivatives of Expected Antimicrobial Activity through DNA Gyrase‐B Inhibition

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