Effect of ring size on properties of technetium amine oxime complexes. X-ray structures of TcO2Pent(AO)2, which contains an unusual eight-membered chelate ring, and of TcOEn(AO)2

99mTc Labeling of Highly Potent Small Peptides

“…The [TcdO] 3+ core forms square pyramidal oxotechnetium complexes, often with tetradentate ligands, which include N 4 propylene amine oxime (87), N 3 S triamidethiols (24,54,55,(57)(58)(59), N 2 S 2 diamidedithiols (24,31,32,54,74), N 2 S 2 monoamidemonoaminedithiols (69,77,79), and N 2 S 2 diaminedithiols (61)(62)(63)(64)(65). Functionalization on the ligand backbone of these chelators results in syn and anti isomers due to the relative orientation of the functional group to the TcdO core .…”

Crystal Structure of 3,3,10,10-Tetramethyl-4,9-diazadodecane-2,11-dione-dioxime Hydrochloride

“…The bond lengths and angles are normal and similar to those with a related structure. 3 There is clear evidence of a double bond at N2-C6 (1.278(2)Å) and single bonds are at N1-C2 (1.483(2)Å) and N1-C3 (1.500(2)Å). One of the nitrogen atoms (N1) of the ligand is half protonated with one side NH 2 + and half protonated with other side NH 2 + (one of the H-atom is disordered).…”

“…3 The title compound ( Fig.1) is also interesting to us as part of a continuing investigation for hypoxia study.…”

Structure of trans-aquanitrido(1,4,8,11-tetraazacyclotetradecan-5-onato-N,N',N'',N''')technetium(V) chloride dihydrate

“…Throughout this paper the form [T~----O] 3+ is used to describe the Tc--oxo multiple bond according to the well known bond situation in oxo complexes where the M--O bond has three components (one ~r and two rr), out of which two are covalent and one is donor-acceptor (Tc----~O) (Shustorovich, Porai-Koshits & Buslaev, 1975). This formalism is useful to distinguish the bond situation in oxo [Tc-~-O] 3+ complexes, where Tc--O distances fall in the range 1.61-1.68 A with stretching frequencies in the range 920-1020cm -~, from that in dioxo [O--Tc=O] + complexes where the distances and stretching frequencies occur in the ranges 1.74-1.75 A and 790-880cm -~ respectively (Zuckman, Freeman, Troutner, Volkert, Holmes, Van Derveer & Kent Barefield, 1981;Kastner, Lindsay & Clarke, 1982;Jurisson, Aston, Fair, Schlemper, Sharp & Troutner, 1987).…”

“…dithiolates, amino-oxime ligands) (Bryson, Dewan, Lister-James, Jones & Davison, 1988;Jurisson et al, 1987;Jurisson, Schlemper, Troutner, Canning, Nowotnik & Neirinckx, 1986) can cross the blood barrier and this fact seems to indicate that the formation of a square-pyramidal structure containing an apical TcX group (X= O, N) is a favourable feature for obtaining potential radiopharmaceutical agents for brain imaging. On the other hand it is well known that technetium(V) tends to form dioxooctahedral complexes with neutral or poor zr-donor ligands such as in [TcO2(en)2] ÷ (en=ethylen-diamine) and [TcO2(cyclam)] ÷ (Kastner et al, 1982;Zuckman et al, 1981).…”