Effect of ricin on biosynthesis of myeloma protein (IgA) and general cellular proteins in MOPC-315 cells

Action of ricin from Ricinus communis L. seeds on eukaryote ribosomal proteins

“…Since the discovery by Dirheimer et al [1 ] that ricin inhibits protein synthesis at the ribosome level in rats, evidence has accumulated showing that this toxin exerts its protein synthesis inhibition in intact cells [2][3][4][5] as well as in cell-free systems [6][7][8], but only on eukaryotes [9,10]. Montanaro et al [11"] and Sperti et al [12] have shown that the target of action of ricin in rat liver protein synthesis is on the 60-S ribosomal subunits.…”