Effect of rice and salty rice diets on the structure of mouse stomach

Kodama, Mitsuo; Kodama, Toshiko; Suzuki, Harumi; Kondo, Ken

doi:10.1080/01635588509513817

Cited by 44 publications

(17 citation statements)

References 14 publications

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“…110 In later studies, Swiss/ICR mice fed salted (10% w/w NaCl) rice diets for 3-12 months were noted to have developed hypertrophy of the forestomach but atrophy (considered a marker of premalignancy in humans) of the glandular stomach. 111 The authors emphasized that a reduction in the parietal cells accounted for the atrophy observed in the fundus of the mice. 111 114 It will be interesting to ascertain whether these results can also be duplicated in animal models.…”

Section: Micementioning

confidence: 99%

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Helicobacter species and in vivo models of gastrointestinal cancer

Fox¹

1998

Aliment Pharmacol Ther

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Section: Micementioning

confidence: 99%

“…111 The authors emphasized that a reduction in the parietal cells accounted for the atrophy observed in the fundus of the mice. 111 114 It will be interesting to ascertain whether these results can also be duplicated in animal models.…”

Section: Micementioning

confidence: 99%

Helicobacter species and in vivo models of gastrointestinal cancer

Fox¹

1998

Aliment Pharmacol Ther

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“…Estudos epidemiológicos sobre os padrões de ocorrência e óbito por CE em populações de migrantes (Haenszel, 1961;Haenszel & Kurihara, 1968;Haenszel et al, 1972;Correa et al, 1973;McMichael et al, 1980;Kolonel et al, 1981Kolonel et al, , 1983Miller, 1982;Rosen Waike, 1984;Correa et al, 1985;Jedrychowski et al, 1986;Hu et al, 1988) vêm reforçando a idéia da associação entre essa neoplasia e alguns fatores encontrados em certos padrões de dieta, dentre eles o sal, hoje imputado como um fator que lesa a mucosa gástrica facilitando a ação de agentes genotóxicos. Evidências experimentais foram obtidas com ratos que receberam dietas ricas em sal, comprovando que este leva à atrofia gástrica (Capoferro & Torgensen, 1974;Kodama et al, 1984), além de estar fortemente associado a metaplasia, facilitar a carcinogênese no estômago na presença de outros carcinóge-nos (Tatematsu et al, 1975;Ohgaki & Kato, 1984;Takahashi et al, 1984;Correa, 1988) e aumentar a absorção dos hidrocarbonetos policí-clicos aromáticos (Capoferro & Torgensen, 1974), que são substâncias carcinogênicas para animais e, provavelmente, para seres humanos.…”

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Câncer de estômago: fatores de risco

Britto

1997

Cad. Saúde Pública

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“…22 Swiss/ICR mice fed salted rice diets developed glandular atrophy. 23 In addition, a concentrated salt diet caused excessive cell proliferation in the gastric mucosa in rodent models. 24 A recent study showed that outbred Mongolian Gerbils fed a 2.5% salt diet for 56 weeks developed atrophic gastritis and intestinal metaplasia.…”

Section: Introductionmentioning

confidence: 99%

Intestinal metaplasia with a high salt diet induces epithelial proliferation and alters cell composition in the gastric mucosa of mice

Xiao

Crissey²,

Lynch³

et al. 2005

Cancer Biology & Therapy

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Intestinal metaplasia of the gastric mucosa is an important component in the pathway to adenocarcinoma. The mechanisms that induce the progression from intestinal metaplasia to cancer have not been elucidated. High dietary salt has been known as one of the risk factors for gastric cancer development in humans. Therefore, we investigated the role of high salt diet on gastric epithelial cell proliferation and differentiation, using our mouse model that ectopically expressed Cdx2 homeodomain transcription factor and induced an intestinal metaplastic phenotype in the gastric epithelia. Sixty Cdx2 transgenic and sixty age-matched wild-type littermates were studied. Fifty-percent Cdx2 transgenic and wild type mice were administered a high-salt diet and the other fifty-percent was fed a standard diet starting at 12 weeks after birth. At 10, 20 and 40 weeks after initiation of the diets, histopathological changes were determined by Hemotoxylin and Eosin, alcian blue, and periodic acid-Schiff (PAS) staining. Cell types and cell kinetics were assessed by immunohistochemistry. At 52 weeks, significant alterations in pathology were observed in the Cdx2 transgenic mice fed a high-salt diet, including elongation of gastric pits, reduction of the glandular zone in the gastric corpus, and deepening of glands in the antrum. In the Cdx2 transgenic mice fed a high salt diet, the parietal and chief cells were significantly decreased in the gastric corpus. A significant increase in cell proliferation and apoptosis in the corpus and antrum were observed in Cdx2 transgenic mice fed a high-salt diet as compared to wild-type littermates. Taken together, these data implicate that intestinal metaplasia in concert with a high-salt diet induces epithelial proliferation, apoptosis, and alters cellular types in the gastric mucosa of mice. Alteration in the composition of the gastric epithelium may play a role in influencing the microenvironment to engender susceptibility to carcinogens.

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Effect of rice and salty rice diets on the structure of mouse stomach

Cited by 44 publications

References 14 publications

Helicobacter species and in vivo models of gastrointestinal cancer

Helicobacter species and in vivo models of gastrointestinal cancer

Câncer de estômago: fatores de risco

Intestinal metaplasia with a high salt diet induces epithelial proliferation and alters cell composition in the gastric mucosa of mice

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