Effect of Retinopathy of Prematurity on Scotopic Spatial Summation

Hansen, Ronald M.; Tavormina, Jena; Moskowitz, Anne; Fulton, Anne B.

doi:10.1167/iovs.14-14344

Cited by 17 publications

(27 citation statements)

References 21 publications

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“…The present results add to the previously reported evidence 1,2,5,21 that ROP has long-lasting effects on the neurosensory retina and provide new evidence of postreceptor retinal dysfunction in mild ROP. Retinopathy of prematurity, whether mild or severe, perturbs photoreceptor and postreceptor function long after active ROP has resolved.…”

Section: Discussionsupporting

confidence: 85%

“…In mild ROP, the T DA value was normal in most subjects, perhaps a consequence of increased spatial pooling 5 of the remodeled postreceptor retinal circuitry. The Eigengrau ( A 0 ) was abnormal even if T DA was normal (Fig.…”

Section: Discussionmentioning

confidence: 92%

“…3,4 We found that the critical area for complete spatial summation in ROP subjects was significantly larger than in controls. 5 Thus, increased spatial pooling of rod input to postreceptor circuitry may be a factor involved in the normalization of sensitivity in mild ROP subjects. 5 …”

mentioning

confidence: 99%

“…5 Thus, increased spatial pooling of rod input to postreceptor circuitry may be a factor involved in the normalization of sensitivity in mild ROP subjects. 5 …”

mentioning

confidence: 99%

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Increment Threshold Functions in Retinopathy of Prematurity

Hansen

Moskowitz

Bush

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PurposeTo assess scotopic background adaptation in subjects with a history of preterm birth and retinopathy of prematurity (ROP). Retinopathy of prematurity is known to have long-term effects on rod photoreceptor and rod mediated postreceptor retinal function.MethodsRod-mediated thresholds for detection of 3° diameter, 50 ms stimuli presented 20° from fixation were measured using a spatial forced choice method in 36 subjects (aged 9–17 years) with a history of preterm birth and 11 age similar term-born subjects. Thresholds were measured first in the dark-adapted condition and then in the presence of 6 steady background lights (−2.8 to +2.0 log scot td). A model of the increment threshold function was fit to each subject's thresholds to estimate the dark-adapted threshold (TDA) and the Eigengrau (A0, the background that elevates threshold 0.3 log unit above TDA).ResultsIn subjects with a history of severe ROP, both TDA and A0 were significantly elevated relative to those in former preterms who never had ROP and term-born control subjects. Subjects who had mild ROP had normal TDA but elevated A0. Neither TDA nor A0 differed significantly between former preterms who never had ROP and term-born controls.ConclusionsThe results suggest that in severe ROP, threshold is affected at a preadaptation site, possibly the rod outer segment. In mild ROP, changes in the Eigengrau may reflect increased intrinsic noise in the photoreceptor or postreceptor circuitry or both.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 92%

mentioning

confidence: 99%

“…5 Thus, increased spatial pooling of rod input to postreceptor circuitry may be a factor involved in the normalization of sensitivity in mild ROP subjects. 5 …”

mentioning

confidence: 99%

See 2 more Smart Citations

Increment Threshold Functions in Retinopathy of Prematurity

Hansen

Moskowitz

Bush

et al. 2016

Invest. Ophthalmol. Vis. Sci.

Self Cite

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show abstract

“…8,9 With increasing survival of extremely premature neonates (<28 weeks) and very low birthweight (<1500 g at birth) infants, 10 long-term changes afflicting the subretina are now being detected in older children and young adults with former history of ROP and those at risk of ROP. 11,12 This is especially true in emerging economies, such as China and India 13,14 ; interestingly, these countries also have a high incidence of myopia. 15 In addition to ROP and myopia, 16,17 several other ophthalmic conditions, notably diabetic retinopathy, 18 geographic atrophy, 19 and nonarteritic anterior ischemic optic neuropathy 20 display progressive choroidal atrophy (Table).…”

mentioning

confidence: 99%