Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations

Abstract

Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment that impacts critical phases of the fetus’s life and correlates to an increased risk of chronic pathological conditions, such as diabetes, obesity, and cardiovascular diseases, in both the mother's and adult offspring’s life. The dietary intake of naturally occurring antioxidants promotes health benefits and disease prevention. In this regard, maternal dietary intake of polyphenolic antioxidants is linked to a reduced risk of maternal obesity and cardio-metabolic disorders, positively affecting both the fetus and offspring. In this work, we will gather and critically appraise the current literature highlighting the effect/s of the naturally occurring polyphenol antioxidant resveratrol on oxidative stress, inflammation, and other molecular and physiological phenomena associated with pregnancy and pregnancy conditions, such as gestational diabetes, preeclampsia, and preterm labor. The resveratrol impact on prenatal complications and pregnancy-associated structures, such as the fetus and placenta, will also be discussed. Finally, we will draw conclusions from the current knowledge and provide future perspectives on potentially exploiting resveratrol as a therapeutic tool in pregnancy-associated conditions.

The Pharmacological Properties of Red Grape Polyphenol Resveratrol: Clinical Trials and Obstacles in Drug Development

“…Several pharmacological interactions involving resveratrol were also discovered and because of the potential for these interactions to reduce the efficacy of the medication, they are considered hazardous [27]. High-dose resveratrol has hormetic effects in vitro (micromolar range in cell culture media) and in vivo (nanomolar range in the blood) [28][29][30], including pro-oxidant effects [29][30][31][32][33][34], but it also has toxic side effects, such as disrupting the thyroid and causing goiter if used for an extended period of time. Thus, it is important to identify the actual biologically effective concentration range at which this compound should be supplemented in human subjects [35,36].…”

Biochemical and cellular basis of oxidative stress: Implications for disease onset

“…For instance, bardoxolone‐methyl, a synthetic triterpenoid, is being studied for its potential therapeutic effects in diabetic kidney disease, Alport syndrome, advanced solid tumors and lymphomas, among others (Chertow et al, 2021; Hong et al, 2012; Nangaku et al, 2023). Another potential therapeutic antioxidant, resveratrol, has been shown to play a role in a plethora of pathological mechanisms (Giordo, Nasrallah, et al, 2021; Giordo et al, 2022; Giordo, Zinellu, et al, 2021; Posadino et al, 2019; Ramli et al, 2023; Shaito et al, 2020., 2023), and indeed, is currently under study for its potential role in delaying memory deterioration in patients with Alzheimer's disease as well as for cardiac remodeling in hypertensive patients (Huhn et al, 2018; Marx et al, 2018; Zheng et al, 2023). Other examples includes beta‐carotene, isothiocyanate sulforaphane, GKT137831 (pyrazolopyridine dione derivative), flavonoids, and others (Bisol et al, 2020; Dao et al, 2015; Fardoun et al, 2020; Maaliki et al, 2019; Schmidt et al, 2015; Slika et al, 2022).…”

Prevention and Co-Management of Breast Cancer-Related Osteoporosis Using Resveratrol

“…Further, resveratrol also appears to be a promising natural substance for the prevention of BC recurrence during pregnancy, without negative effects on the embryo [ 178 ]. Indeed, positive effects of resveratrol on embryogenesis and the prevention of BC during pregnancy and pregnancy complications as well as on improvements in reproductive health have been reported [ 179 , 180 ].…”