Effect of Resveratrol on Critical-Sized Calvarial Defects of Diabetic Rats: Histometric and Gene Expression Analysis

Pino, Danilo Siqueira; Casarin, Renato Corrêa Viana; Pimentel, Suzana Peres; Cirano, Fabiano Ribeiro; Corrêa, Mônica Grazieli; Ribeiro, Fernanda Vieira

doi:10.1016/j.joms.2017.07.167

Cited by 12 publications

(17 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, they also supported that RSV supplementation at low dosage (1 mg/kg) preserved the growth plate, primary spongiosa, bone volume, and lowered the adipocyte density of tibia bone. In calvarial defect models, they proposed that nondiabetic animals presented with the highest levels of osteopontin and Runx2 mRNA compared with all other groups at dosage of 10 mg/kg 37 , and resveratrol significantly affected the levels of expression of bone morphogenetic protein 2, bone morphogenetic protein 7, and osteopontin 33 . In our study, although the dosage of resveratrol was at 5 mg/kg/day, osteopontin expression was increased in osteoblasts and osteocytes cells of new bone trabeculae.…”

Section: Discussionmentioning

confidence: 40%

See 1 more Smart Citation

Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats

Laçin

Deveci

2019

Acta Cir. Bras.

View full text Add to dashboard Cite

Purpose:The effects of resveratrol administration on calvarial bone defects with alloplastic graft material was investigated for osteoinductive reaction and bone development in rats.Methods:Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows: control (defect) group, defect + graft group, and defect + graft + resveratrol group. A calvarial bone defect was created in all groups, alloplastic bone grafts were applied to the defect in the 2nd and 3rd group, resveratrol (5 mg/kg/day) was added to the drinking water of the animals following graft application for 28 days in the 3rd group.Results:Increase in osteoclasts and necrotic changes were observed histopathologically in the control group. In the 2nd group, reduction of inflammation, congestion of blood vessels, increased osteblastic activity, osteoinductive effect, progression of osteocyte development and increased collagen fibers in connective tissue were observed. In the 3rd group, osteoblasts seemed to secrete bone matrix and accelerate osteoinductive effect with increased osteopregenitor activity and positive osteopontin and osteonectin expressions.Conclusion:Resveratrol treatment was thought to be an alternative and supportive drug for implant application by inducing new bone formation in the calvaral defect region as a result of short-term treatment.

show abstract

Section: Discussionmentioning

confidence: 40%

“…and they verified that RSV prevented bone density loss. Pino et al 37 . examined the effect of RSV on critical-sized calvarial defects of diabetic rats via histometric and gene expression analysis.…”

Section: Discussionmentioning

confidence: 99%

Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats

Laçin

Deveci

2019

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

“…54 Effect of resveratrol on critical-sized calvarial defects of diabetic rats: histometric and gene expression analysis. 55 Nov 2017, Vol. 75, Issue 11 27 3 (11.11%)…”

Section: Resultsmentioning

confidence: 99%

February’s 2020 Full Issue PDF

2020

J. Diagn. Treat. Oral Maxillofac. Pathol.

View full text Add to dashboard Cite

This is a monthly peer-reviewed oral and maxillofacial surgery journal focused on: Microvascular and jaw reconstructive surgery, dental implants, salivary gland tumors/diseases, TMJ lesions, virtual surgical planning, implementation of ultrasonography into the practice of oral and maxillofacial surgeons. Editorial Board (EB) CompositionEB shows significant geographic diversity representing 24 opinion leaders from 13 countries: Brazil,

show abstract

“…The histometric results indicated smaller residual calvarial defects in rats treated with RSV or RSV + INS that appeared in accordance to higher gene expression of BMP-2 observed in the RSV + INS group. No remarkable increase in BMP-2 gene expression was made evident in rats treated with RSV alone, demonstrating that only the combined RSV and INS administration was effective to markedly increase BMP-2 expression [41].…”

Section: In Vivo Studiesmentioning

confidence: 99%

Advance on Resveratrol Application in Bone Regeneration: Progress and Perspectives for Use in Oral and Maxillofacial Surgery

et al. 2019

View full text Add to dashboard Cite

The natural polyphenol Resveratrol (RSV) claims numerous positive effects on health due to the well documented biological effects demonstrating its potential as a disease-preventing agent and as adjuvant for treatment of a wide variety of chronic diseases. Since several studies, both in vitro and in vivo, have highlighted the protective bone aptitude of RSV both as promoter of osteoblasts’ proliferation and antagonist of osteoclasts’ differentiation, they could be interesting in view of applications in the field of dentistry and maxillofacial surgery. This review has brought together experimental findings on the use of RSV in the regeneration of bone tissue comprising also its application associated with scaffolds and non-transfusional hemocomponents.

show abstract

Effect of Resveratrol on Critical-Sized Calvarial Defects of Diabetic Rats: Histometric and Gene Expression Analysis

Cited by 12 publications

References 48 publications

Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats

Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats

February’s 2020 Full Issue PDF

Advance on Resveratrol Application in Bone Regeneration: Progress and Perspectives for Use in Oral and Maxillofacial Surgery

Contact Info

Product

Resources

About