Effect of Resveratrol Administration on the Element Metabolism in the Blood and Brain Tissues of Rats Subjected to Acute Swimming Exercise

Baltacı, Abdülkerim Kasım; Arslangil, Dilek; Moğulkoç, Rasim; Patlar, Süleyman

doi:10.1007/s12011-016-0792-2

Cited by 10 publications

(5 citation statements)

References 32 publications

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“…Hepatic Co levels were also reduced in rats exposed to strenuous swimming exercise (Sivrikaya et al, 2013). Oppositely, swimming in rats resulted in a significant increase in serum cobalt levels, being attenuated by resveratrol treatment (Baltaci et al, 2017).…”

Section: Cobalt Status In Athletesmentioning

confidence: 94%

Cobalt in athletes: hypoxia and doping - new crossroads

Skalny¹,

Zaitseva²,

Gluhcheva³

et al. 2019

J Appl Biomed

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Cobalt is an essential trace element that is known to mimic hypoxia and hypoxic training. Inorganic Co compounds are capable of Hypoxiainducible factor-1 (HIF-1) activation, resulting in up-regulation of gene expression including erythropoietin (Epo). Experimental studies have demonstrated that Co treatment may increase hypoxic tolerance of different tissues, improve muscle metabolism and exercise performance. Other mechanisms may also involve modulation of steroid hormone and iron metabolism. Based on these experimental studies, in 2017 inorganic cobalt compounds were added into the World Anti-Doping Agency (WADA) prohibited list as doping agents. However, the existing data on beneficial effects of cobalt on exercise performance in athletes are scarce. Similarly, only experimental studies demonstrated exercise-induced decrease in tissue Co levels, whereas human data are inconsistent. In addition, multiple studies have demonstrated that excessive Co intake may be toxic due to prooxidant, proinflammatory, and proapoptotic activity. Therefore, monitoring of Co deficiency and overload is required to prevent potential health hazards in athletes. At the same time, modulation of Co status should be performed through supplementation avoiding excessive doses of inorganic cobalt that are used for doping and are accompanied by adverse health effects of metal toxicity.

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Section: Cobalt Status In Athletesmentioning

confidence: 94%

Cobalt in athletes: hypoxia and doping - new crossroads

Skalny¹,

Zaitseva²,

Gluhcheva³

et al. 2019

J Appl Biomed

View full text Add to dashboard Cite

show abstract

“…Furthermore, Guo and coworkers [146] demonstrated that 9-week supplementation (50 mg/kg/day) improved reproductive function in rats subjected to high-intensity workouts by increasing sperm density, testosterone, and follicle-stimulating hormone levels, protamine, superoxide dismutase activity, and spermatogenic epithelial cell number, and reducing inflammatory markers (IL-6, TNF-α, and malondialdehyde content). On the other hand, resveratrol supplementation (10 mg/kg/day) for 4 weeks exerted a regulatory effect on serum iron and magnesium levels in rats' blood undergoing acute swimming exercises [147]. Moreover, an 8-week supplementation at 20 mg/kg in diabetic rats exposed to regular continuous exercise increased B-cell lymphoma 2 (BCL-2) levels, and reduced Bcl-2-associated X-protein (BAX), caspase 3 [148], and hepatocyte apoptosis [29].…”

Section: Rodent Modelsmentioning

confidence: 99%

Effects of Functional Phenolics Dietary Supplementation on Athletes’ Performance and Recovery: A Review

Gonçalves

Gaspar

Flores-Félix

et al. 2022

IJMS

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In recent years, many efforts have been made to identify micronutrients or nutritional strategies capable of preventing, or at least, attenuating, exercise-induced muscle damage and oxidative stress, and improving athlete performance. The reason is that most exercises induce various changes in mitochondria and cellular cytosol that lead to the generation of reactive species and free radicals whose accumulation can be harmful to human health. Among them, supplementation with phenolic compounds seems to be a promising approach since their chemical structure, composed of catechol, pyrogallol, and methoxy groups, gives them remarkable health-promoting properties, such as the ability to suppress inflammatory processes, counteract oxidative damage, boost the immune system, and thus, reduce muscle soreness and accelerate recovery. Phenolic compounds have also already been shown to be effective in improving temporal performance and reducing psychological stress and fatigue. Therefore, the aim of this review is to summarize and discuss the current knowledge on the effects of dietary phenolics on physical performance and recovery in athletes and sports practitioners. Overall, the reports show that phenolics exert important benefits on exercise-induced muscle damage as well as play a biological/physiological role in improving physical performance.

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“…The beneficial roles of trace elements in many physiological and metabolic functions of biological systems have been shown in the literature. Trace element levels should be kept within optimal limits to support the metabolic functions of body systems (8,9). Marked variation in levels of trace elements including iron and zinc, response to the exercise induced increased metabolic stress has been shown (10).…”

Section: Introductionmentioning

confidence: 99%

Investigation of Some Trace Element Levels in Multiple Sclerosis

2021

Kastamonu Med J

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Purpose: In this study, it was aimed to investigate the relationship between MS and the homeostatic state of trace elements, and to reveal the relationship between Fe and Zn in MS pathology Material and Method: Total of 40 (20 patients and 20 control) subjects were participated to this study. Blood samples were taken and analysed plasma iron and zinc levels using an atomic Absorption Spectrophotometer. Kolmogrow-Smirnov Z test used to analyse statistically significance of the data. P<0.05 was accepted as significant. Results: The plasma iron and Zn levels were found to be significantly lower in MS patients compared to control. Conclusion: Considering the important beneficial effects of iron and zinc against neurodegenerative disease and increased oxidative stress, reduced level of these trace elements should be considered in MS treatment.

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Effect of Resveratrol Administration on the Element Metabolism in the Blood and Brain Tissues of Rats Subjected to Acute Swimming Exercise

Cited by 10 publications

References 32 publications

Cobalt in athletes: hypoxia and doping - new crossroads

Cobalt in athletes: hypoxia and doping - new crossroads

Effects of Functional Phenolics Dietary Supplementation on Athletes’ Performance and Recovery: A Review

Investigation of Some Trace Element Levels in Multiple Sclerosis

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