Effect of rest deprivation on motor activity of fish

Tobler, Irene; Borbély, Alexander A.

doi:10.1007/bf01350078

Cited by 43 publications

(27 citation statements)

References 10 publications

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“…Most strikingly, we also found that light was not only able to suppress sleep (Figures 2 and S1) but that no sleep rebound was observed upon release in the dark. In goldfish and perch, a sleep rebound in the light has been found after sleep deprivation by light, but was mild [7]. Further, the lack of rebound after sleep deprivation by light in our experiment contrasts with the observation of homeostatic regulation after a much lower level of sleep deprivation using electrical stimulation.…”

Section: Discussioncontrasting

confidence: 80%

Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants

et al. 2007

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Sleep is a fundamental biological process conserved across the animal kingdom. The study of how sleep regulatory networks are conserved is needed to better understand sleep across evolution. We present a detailed description of a sleep state in adult zebrafish characterized by reversible periods of immobility, increased arousal threshold, and place preference. Rest deprivation using gentle electrical stimulation is followed by a sleep rebound, indicating homeostatic regulation. In contrast to mammals and similarly to birds, light suppresses sleep in zebrafish, with no evidence for a sleep rebound. We also identify a null mutation in the sole receptor for the wake-promoting neuropeptide hypocretin (orexin) in zebrafish. Fish lacking this receptor demonstrate short and fragmented sleep in the dark, in striking contrast to the excessive sleepiness and cataplexy of narcolepsy in mammals. Consistent with this observation, we find that the hypocretin receptor does not colocalize with known major wake-promoting monoaminergic and cholinergic cell groups in the zebrafish. Instead, it colocalizes with large populations of GABAergic neurons, including a subpopulation of Adra2a-positive GABAergic cells in the anterior hypothalamic area, neurons that could assume a sleep modulatory role. Our study validates the use of zebrafish for the study of sleep and indicates molecular diversity in sleep regulatory networks across vertebrates.

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Section: Discussioncontrasting

confidence: 80%

Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants

et al. 2007

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“…Evidence for circadian and homeostatic regulation of a sleep-like state has been found in insects [11,12], notably fruit flies [13,14], and in fish [15]. Prolonged rest deprivation by instrumental manipulations (shaking, lights, sounds) induces compensatory recovery rest when the disturbance is ended.…”

Section: Rest-activity Homeostasismentioning

confidence: 98%

Neuroanatomy and neurochemistry of sleep

Stenberg

2007

Cell. Mol. Life Sci.

129

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Sleep is regulated by homeostatic and circadian factors, and the regulation of sleep of mammals shares many molecular properties with the rest state of submammalian species. Several brain structures take part in waking: the basal forebrain, posterior and lateral hypothalamus, and nuclei in the tegmentum and pons. Active sleep mechanisms are located to the preoptic/anterior hypothalamic area. In addition to acetylcholine and monoamines, glutamate and hypocretin/orexin are important waking factors. Gamma-aminobutyric acid and several peptide factors, including cytokines, growth hormone-releasing hormone and prolactin, are related to sleep promotion. Adenosine is an important homeostatic sleep factor acting in basal forebrain and preoptic areas through A1 and A2A receptors. Prolonged waking activates inducible nitric oxide synthase in the basal forebrain, which through energy depletion causes adenosine release and recovery sleep. Numerous genes have been found differentially displayed in waking compared with sleep, and they relate to neural transmission, synaptic plasticity, energy metabolism and stress protection. The genetic background of a few sleep disorders has been solved.

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“…In the early 1980s, Irene Tobler extended this definition of sleep using additional behavioral criteria [4-6]: [i] decreased behavioral activity (immobility), [ii] site preference (e.g. bed), [iii] specific posture (e.g.…”

Section: Introductionmentioning

confidence: 99%

Synaptic plasticity in sleep: learning, homeostasis and disease

Wang

Grone

Colas

et al. 2011

Trends in Neurosciences

147

102

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Sleep is a fundamental and evolutionarily conserved aspect of animal life. Recent studies have shed light on the role of sleep in synaptic plasticity. Demonstrations of memory replay and synapse homeostasis suggest that one essential role of sleep is in the consolidation and optimization of synaptic circuits to retain salient memory traces despite the noise of daily experience. Here, we review this recent evidence, and suggest that sleep creates a heightened state of plasticity, which may be essential for this optimization. Furthermore, we discuss how sleep deficits seen in diseases such as Alzheimer’s disease and autism spectrum disorders might not just reflect underlying circuit malfunction, but could also play a direct role in the progression of those disorders.

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Effect of rest deprivation on motor activity of fish

Cited by 43 publications

References 10 publications

Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants

Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants

Neuroanatomy and neurochemistry of sleep

Synaptic plasticity in sleep: learning, homeostasis and disease

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