Effect of Resistance Training With Total and Partial Blood Flow Restriction on Biomarkers of Oxidative Stress and Apoptosis in Untrained Men

Lima, Fábio Rocha; Marin, Douglas Popp; Ferreira, Letícia Torres; Sousa-Filho, Celso Pereira Batista; Astorino, Todd A.; Prestes, Jonato; Marquezi, Marcelo Luís; Otton, Rosemari

doi:10.3389/fphys.2021.720773

Cited by 5 publications

(34 citation statements)

References 53 publications

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“…LLRE intensity varied between 20-50% 1RM while exercise in the HLRE varied between 70-80% 1RM. Of the 13 studies included in this review, six performed exercise to failure [36][37][38][39]44,45] but none of these trials reported equalizing training volume (total repetitions × load) between groups (LLRE-BFR versus HLRE or LLRE); one of them calculated training volume [45]. In this study, the LLRE-BFR group had ~2.3-fold greater training volume compared to HLRE.…”

Section: Exercise Protocolmentioning

confidence: 85%

“…The 13 studies in this review are summarized in Table 1 and included 158 subjects. Eight studies used a cross-over/inter-subject design [18,[36][37][38][39][40][41][42] and five studies used a parallel design PLOS ONE [43][44][45][46][47]. Included studies generally consisted of small sample sizes ranging from six [43] to twenty-eight subjects [47].…”

Section: Study Selection and Sample Characteristicsmentioning

confidence: 99%

“…The studied populations were young male subjects between 18 and 35 years old. Five studies were composed of resistance trained subjects [18,36,37,40,41], four trials were conducted in physically / recreationally active men [38,39,44,47], one study classified its subjects as athletes [42], but provided no details about their training routine, while another three studies included sedentary/untrained subjects [43,45,46].…”

Section: Study Selection and Sample Characteristicsmentioning

confidence: 99%

“…Four of the thirteen studies performed both upper and lower limb resistance exercise [36,38,39,47] whereas five studies performed just upper [38,39,42,44,45], and four performed just lower limb exercises [18,41,44,45]. LLRE intensity varied between 20-50% 1RM while exercise in the HLRE varied between 70-80% 1RM.…”

Section: Exercise Protocolmentioning

confidence: 99%

“…The most frequently used sampling time point for oxidative stress markers was immediately post-exercise (up to two minutes following completion) in twelve studies [18,[36][37][38][39][40][42][43][44][45][46][47], PLOS ONE after 24 hours in four studies [39,41,44,45] and only two trials [39,41] sampled 48 hours postexercise. When studies aimed to compare the effects of different degrees of limb occlusion pressure on oxidative stress markers [18,41,45], we only considered the 75% and 50% limb occlusion pressure groups to align with recent practice guidelines [6].…”

Section: Exercise Protocolmentioning

confidence: 99%

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Acute effect of low-load resistance exercise with blood flow restriction on oxidative stress biomarkers: A systematic review and meta-analysis

et al. 2023

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Background The purpose of this review was to analyze the acute effects of low-load resistance exercise with blood flow restriction (LLE-BFR) on oxidative stress markers in healthy individuals in comparison with LLE or high-load resistance exercise (HLRE) without BFR. Materials and methods A systematic review was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. These searches were performed in CENTRAL, SPORTDiscus, EMBASE, PubMed, CINAHL and Virtual Health Library- VHL, which includes Lilacs, Medline and SciELO. The risk of bias and quality of evidence were assessed through the PEDro scale and GRADE system, respectively. Results Thirteen randomized clinical trials were included in this review (total n = 158 subjects). Results showed lower post-exercise damage to lipids (SMD = -0.95 CI 95%: -1.49 to -0. 40, I2 = 0%, p = 0.0007), proteins (SMD = -1.39 CI 95%: -2.11 to -0.68, I2 = 51%, p = 0.0001) and redox imbalance (SMD = -0.96 CI 95%: -1.65 to -0.28, I2 = 0%, p = 0.006) in favor of LLRE-BFR compared to HLRE. HLRE presents higher post-exercise superoxide dismutase activity but in the other biomarkers and time points, no significant differences between conditions were observed. For LLRE-BFR and LLRE, we found no difference between the comparisons performed at any time point. Conclusions Based on the available evidence from randomized trials, providing very low or low certainty of evidence, this review demonstrates that LLRE-BFR promotes less oxidative stress when compared to HLRE but no difference in levels of oxidative damage biomarkers and endogenous antioxidants between LLRE. Trial registration Register number: PROSPERO number: CRD42020183204.

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Section: Exercise Protocolmentioning

confidence: 85%

Section: Study Selection and Sample Characteristicsmentioning

confidence: 99%

Section: Study Selection and Sample Characteristicsmentioning

confidence: 99%

Section: Exercise Protocolmentioning

confidence: 99%

Section: Exercise Protocolmentioning

confidence: 99%

See 3 more Smart Citations

Acute effect of low-load resistance exercise with blood flow restriction on oxidative stress biomarkers: A systematic review and meta-analysis

et al. 2023

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Salivary proteomic profile of response to different resistance training protocols: A case report

Santos,

Filho,

Ventura

et al. 2024

Cell Biochemistry & Function

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Resistance training (RT) with blood flow restriction (BFR) or high intensity (HI) are effective to increase muscle mass. To understand this effect, techniques known as “omics” are used to identify possible biomarkers. This study analyzed the salivary proteomic profile of healthy individuals trained before and after two RT protocols both designed with eight exercises for upper‐ and lower‐limbs, one performed at low percentage of one‐maximum repetition (%1RM) with BFR technique, and other at high %1RM (HI) without BRF technique. Four healthy males between 18 and 28 years participated in the study. Stimulated saliva was collected before (BBFR/BHI) and immediately after (ABFR/AHI) the two RT protocols. All protein‐related processing was performed using label‐free proteomic. The difference in expression between groups was expressed as p < .05 for downregulated proteins and 1‐p > .95 for upregulated proteins. There was difference in salivary flow between ABFR and BBFR (p = .005). For HI, 87 proteins were found after the practice and 119 before. Three hemoglobin isoforms were increased in AHI compared with BHI. In the BFR comparison, 105 proteins were identified after (ABFR) and 70 before (BBFR). Among those increased ABFR, we highlight five hemoglobin isoforms and Deleted in malignant brain tumors 1 protein. Between ABFR and AHI, 17 isoforms of histones, Transaldolase, Transketolase, Glyceraldehyde‐3‐phosphate dehydrogenase, and Antileukoproteinase were decreased ABFR. For HI, there was an increase in proteins related to oxidative stress and metabolism of the musculoskeletal system, compared with BFR. HI seems to induce higher anabolic signaling to muscle mass increase and antiatherosclerotic effects.

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Hormonal, immune, and oxidative stress responses to blood flow‐restricted exercise

Hjortshoej,

Aagaard,

Storgaard

et al. 2023

Acta Physiologica

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IntroductionHeavy‐load free‐flow resistance exercise (HL‐FFRE) is a widely used training modality. Recently, low‐load blood‐flow restricted resistance exercise (LL‐BFRRE) has gained attention in both athletic and clinical settings as an alternative when conventional HL‐FFRE is contraindicated or not tolerated. LL‐BFRRE has been shown to result in physiological adaptations in muscle and connective tissue that are comparable to those induced by HL‐FFRE. The underlying mechanisms remain unclear; however, evidence suggests that LL‐BFRRE involves elevated metabolic stress compared to conventional free‐flow resistance exercise (FFRE).AimThe aim was to evaluate the initial (<10 min post‐exercise), intermediate (10–20 min), and late (>30 min) hormonal, immune, and oxidative stress responses observed following acute sessions of LL‐BFRRE compared to FFRE in healthy adults.MethodsA systematic literature search of randomized and non‐randomized studies was conducted in PubMed, Embase, Cochrane Central, CINAHL, and SPORTDiscus. The Cochrane Risk of Bias (RoB2, ROBINS‐1) and TESTEX were used to evaluate risk of bias and study quality. Data extractions were based on mean change within groups.ResultsA total of 12525 hits were identified, of which 29 articles were included. LL‐BFRRE demonstrated greater acute increases in growth hormone responses when compared to overall FFRE at intermediate (SMD 2.04; 95% CI 0.87, 3.22) and late (SMD 2.64; 95% CI 1.13, 4.16) post‐exercise phases. LL‐BFRRE also demonstrated greater increase in testosterone responses compared to late LL‐FFRE.ConclusionThese results indicate that LL‐BFRRE can induce increased or similar hormone and immune responses compared to LL‐FFRE and HL‐FFRE along with attenuated oxidative stress responses compared to HL‐FFRE.

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Effect of Resistance Training With Total and Partial Blood Flow Restriction on Biomarkers of Oxidative Stress and Apoptosis in Untrained Men

Cited by 5 publications

References 53 publications

Acute effect of low-load resistance exercise with blood flow restriction on oxidative stress biomarkers: A systematic review and meta-analysis

Acute effect of low-load resistance exercise with blood flow restriction on oxidative stress biomarkers: A systematic review and meta-analysis

Salivary proteomic profile of response to different resistance training protocols: A case report

Hormonal, immune, and oxidative stress responses to blood flow‐restricted exercise

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