Effect of resistance training volume on body adiposity, metabolic risk, and inflammation in postmenopausal and older females: Systematic review and meta-analysis of randomized controlled trials

Nunes, Paulo Ricardo Prado; Castro-e-Souza, Pâmela; de Oliveira, Anselmo Alves; Camilo, Bruno de Freitas; Cristina-Souza, Gislaine; Vieira-Souza, Lucio Marques; Carneiro, Marcelo Augusto da Silva

doi:10.1016/j.jshs.2023.09.012

Cited by 1 publication

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“…Short-term ST has been found to reduce hepatic fat accumulation and enhance liver insulin sensitivity in male rodents [30]. A recent study by Nunes et al [31] further supports these findings, showing that highvolume resistance training can improve the metabolic profile and inflammation in obese and postmenopausal women.…”

Section: Introductionmentioning

confidence: 75%

Strength Training Protects High-Fat-Fed Ovariectomized Mice against Insulin Resistance and Hepatic Steatosis

Santos,

Silva,

Alves

et al. 2024

IJMS

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Menopause is characterized by a reduction in sex hormones in women and is associated with metabolic changes, including fatty liver and insulin resistance. Lifestyle changes, including a balanced diet and physical exercise, are necessary to prevent these undesirable changes. Strength training (ST) has been widely used because of the muscle and metabolic benefits it provides. Our study aims to evaluate the effects of ST on hepatic steatosis and insulin resistance in ovariectomized mice fed a high-fat diet (HFD) divided into four groups as follows: simulated sedentary surgery (SHAM-SED), trained simulated surgery (SHAM-EXE), sedentary ovariectomy (OVX-SED), and trained ovariectomy (OVX-EXE). They were fed an HFD for 9 weeks. ST was performed thrice a week. ST efficiently reduced body weight and fat percentage and increased lean mass in OVX mice. Furthermore, ST reduced the accumulation of ectopic hepatic lipids, increased AMPK phosphorylation, and inhibited the de novo lipogenesis pathway. OVX-EXE mice also showed a better glycemic profile, associated with greater insulin sensitivity identified by the euglycemic–hyperinsulinemic clamp, and reduced markers of hepatic oxidative stress compared with sedentary animals. Our data support the idea that ST can be indicated as a non-pharmacological treatment approach to mitigate metabolic changes resulting from menopause.

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Section: Introductionmentioning

confidence: 75%