Effect of resistance training on inflammatory markers of older adults: A meta-analysis

Sardeli, Amanda Veiga; Tomeleri, Crisieli M.; Cyrino, Edílson Serpeloni; Fernhall, Bo; Cavaglieri, Cláudia Regina; Chacon-Mikahil, Mara Patrícia Traina

doi:10.1016/j.exger.2018.07.021

Cited by 119 publications

(99 citation statements)

References 46 publications

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“…In fact, when older adults engaged in AT during weight loss but lost no more weight than dietary weight loss, AT did not confer an added benefit for either CRP or IL-6 (36). In contrast, a recent meta-analysis (16) of RT training studies in older adults reported a moderate reduction in CRP with a marginal effect for IL-6, results that parallel our current findings when RT is combined with WL.…”

Section: Discussionsupporting

confidence: 82%

“…Also, an RT study with older women with MetS found that the reduction in CRP with training was related to increases in muscle mass (37), results that parallel a 12-month RT intervention among older adults with type 2 diabetes (38). It is also known that increases in IL-6 released by muscle during contraction have an anti-inflammatory effect in opposition to the IL-6 released by visceral adiposity, which is proinflammatory (16,39). Specifically, IL-6 from muscle increases IL-10 and IL-1ra, both of which are anti-inflammatory, and does so in the absence of increasing the proinflammatory cytokines tumor necrosis factor-α and IL-1β.…”

Section: Discussionmentioning

confidence: 96%

“…Of note, Woods et al argued that the effects of AT on inflammation are due to reductions in fat mass with training. Of particular significance to the current study is a recent meta‐analysis of the effect of RT on inflammation in older adults that reported a moderate effect size for RT on reducing CRP and a marginal effect on IL‐6 .…”

Section: Introductionmentioning

confidence: 92%

“…The three study arms received the same WL intervention in the following three 6-month phases: intensive (months 1-6), transition (months 7-12), and maintenance (months [13][14][15][16][17][18]. During the initial intensive phase, participants met with trained staff members at a local YMCA for three group sessions and one individual session each month.…”

Section: Interventionmentioning

confidence: 99%

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Dietary Weight Loss, Exercise, and Inflammation in Older Adults with Overweight or Obesity and Cardiometabolic Disease

Rejeski

Marsh

Fanning

et al. 2019

Obesity

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Objective This study aimed to examine exercise modality during weight loss on change in inflammation among older adults with overweight or obesity and cardiometabolic disease. Methods A total of 222 older adults with a mean (SD) age of 66.9 (4.7) years and a mean (SD) BMI of 33.5 (3.5) kg/m2 were randomized to weight loss (WL; n = 68), WL plus aerobic training (WL + AT; n = 79), or WL plus resistance training (WL + RT; n = 75) for 18 months. C‐reactive protein (CRP) and interleukin‐6 were measured at baseline, 6 months, and 18 months. Results All groups lost significant weight from baseline to 18 months, with average adjusted changes of −5.5% for WL, −9.0% for WL + AT, and −10.1% for WL + RT. WL + RT and WL + AT lost significantly more weight than WL (P < 0.05). At 18 months, CRP values in WL + RT were significantly lower than WL (2.25 pg/mL vs. 3.38 pg/mL; P = 0.004). The only difference in interleukin‐6 was that at 18 months, WL + RT was lower than WL + AT (2.32 pg/mL vs. 2.75 pg/mL; P = 0.03). Conclusions The addition of RT during WL was more effective at reducing levels of CRP than WL. Although results were in the expected direction, there was no difference in CRP between WL and WL + AT.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 92%

Section: Interventionmentioning

confidence: 99%

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Dietary Weight Loss, Exercise, and Inflammation in Older Adults with Overweight or Obesity and Cardiometabolic Disease

Rejeski

Marsh

Fanning

et al. 2019

Obesity

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“…One recent review of 83 randomized and non‐randomized trials found an overall reduction in CRP following physical activity, albeit with a small effect size (Fedewa, Hathaway, & Ward‐Ritacco, ). Other reviews have demonstrated similar effects of exercise within specific patient populations such as breast cancer survivors (Meneses‐Echavez et al, ), patients with type 2 diabetes (Hayashino et al, ), and older adults (Sardeli et al, ). However, effects are mixed and may depend on the population, exercise intensity and duration, and the inflammatory marker assessed.…”

Section: Healthy Behaviors and The Neuro‐immune Networkmentioning

confidence: 76%

Cultivating a healthy neuro‐immune network: A health psychology approach

Bower

Kuhlman

Haydon

et al. 2019

Social & Personality Psych

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The field of psychoneuroimmunology (PNI) examines interactions among psychological and behavioral states, the brain, and the immune system. Research in PNI has elegantly documented effects of stress at multiple levels of the neuro‐immune network, with profound implications for both physical and mental health. In this review, we consider how the neuro‐immune network might be influenced by “positive” psychological and behavioral states, focusing on positive affect, eudaimonic well‐being, physical activity, and sleep. There is compelling evidence that these positive states and behaviors are associated with changes in immune activity in the body, including reductions in peripheral inflammatory processes relevant for physical health. Growing evidence from animal models also suggests effects of positive states on immune cells in the brain and the blood‐brain barrier, which then impact critical aspects of mood, cognition, and behavior. Tremendous advances are being made in our understanding of neuro‐immune dynamics; one of the central goals of this review is to highlight recent preclinical research in this area and consider how we can leverage these findings to investigate and cultivate a healthy neuro‐immune network in humans.

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Combined training and hormones/enzymes with insulinotropic actions in individuals with overweight and type 2 diabetes mellitus: A randomized controlled trial

Bonfante,

Duft,

Mateus

et al. 2024

European Journal of Sport Science

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The incretins (glucose‐dependent insulinotropic polypeptide [GIP] and glucagon‐like peptide‐1 [GLP‐1]), along with amylin/islet amyloid polypeptide (IAPP) and insulin‐degrading enzyme (IDE), are hormones/enzymes that have been pharmacological targets, such as dipeptidyl peptidase‐4 (DPP‐4) inhibitors, due to their insulinotropic actions. Physical training is recommended as a treatment for type 2 diabetes mellitus (T2DM); however, its effects on the concentrations of these hormones/enzymes are not well known. Thus, the present study aimed to evaluate the effects of combined training (CT) on the concentrations of hormones/enzymes with insulinotropic actions in individuals with T2DM and overweight. Individuals of both sexes with T2DM (age 51.73 ± 4.19 years; body mass index [BMI] 29.46 ± 3.39 kg/m2) were randomly distributed in the control group (CG, n = 17) and the combined training group (CTG, n = 17). The CT consisted of strength followed by erobic training, 3 times/week, for 16 weeks. Functional variables, body composition, and serum biochemical analyses (clinical markers, GLP‐1, GIP, DPP‐4, amylin/IAPP, and IDE) were evaluated. The CTG showed a decrease in GLP‐1 (pre: 32.8 ± 12.1, post: 28.4 ± 13.5, and p = 0.04) in the group/time analysis. In the evaluation of the Δ% of variation, CTG presented a decrease for GLP‐1 (−9.3%; p = 0.03) and amylin/IAPP (−13.4%; p < 0.01), in addition to an increase for DPP‐4 (6.2%; p = 0.04) enzyme. CT decreases the baseline levels of important hormones with insulinotropic actions in individuals with T2DM and overweight. The improvement in overall metabolism provided by CT must be the main reason for these effects. These results broaden the understanding of the effects and relationships between CT and glucose metabolism.

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Effect of resistance training on inflammatory markers of older adults: A meta-analysis

Cited by 119 publications

References 46 publications

Dietary Weight Loss, Exercise, and Inflammation in Older Adults with Overweight or Obesity and Cardiometabolic Disease

Dietary Weight Loss, Exercise, and Inflammation in Older Adults with Overweight or Obesity and Cardiometabolic Disease

Cultivating a healthy neuro‐immune network: A health psychology approach

Combined training and hormones/enzymes with insulinotropic actions in individuals with overweight and type 2 diabetes mellitus: A randomized controlled trial

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