Effect of Resistance Training on Immunological Parameters of Healthy Elderly Women

Raso, Vagner; Benard, Gil; Duarte, Alberto José da Silva; Natale, Valéria Maria

doi:10.1249/mss.0b013e318156e9fa

Cited by 40 publications

(33 citation statements)

References 40 publications

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“…An important aging-related event is the loss of expression of the co-stimulatory molecule CD28 on CD8 + T cells. As in previous studies (Kapasi et al 2003;Raso et al 2007), we did not detect an influence of training on the proportion of CD8 + CD28 neg T cells. Thus, a training lifestyle seems not to exert a major influence in the aging-associated loss of CD28 expression despite modifying the composition of the memory T cell compartment.…”

Section: Discussionsupporting

confidence: 83%

Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations

Silva

Araújo

Fernandes

et al. 2016

AGE

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Studies indicate that exercise might delay human biological aging, but the effects of long-term exercise on T cell function are not well known. We tested the hypothesis that moderate or intense exercise lifestyle may attenuate the effects of aging on the telomere length and the survival and composition of T cell subpopulations. Elderly (65-85 years) with intense training lifestyle (IT, n = 15), moderate training lifestyle (MT, n = 16), and who never trained (NT, n = 15) were studied. Although the three groups presented the ageassociated contraction of the TCD4 + /TCD8 + naïve compartments and expansion of the memory compartments, both training modalities were associated with lower proportion of terminally differentiated (CD45RA + CCR7 neg ) TCD4 + and TCD8 + cells, although among the latter cells, the reduction reached statistical significance only with IT. MT was associated with higher proportion of central memory TCD4 + cells, while IT was associated with higher proportion of effector memory TCD8 + cells. However, both training lifestyles were unable to modify the proportion of senescent (CD28 neg ) TCD8 + cells. Telomeres were longer in T cells in both training groups; with IT, telomere length increased mainly in TCD8 + cells, whereas with MT, a modest increase in telomere length was observed in both TCD8 + and TCD4 + cells. Reduced commitment to apoptosis of resting T cells, as assessed by caspase-3 and Bcl-2 expression, was seen predominantly with IT.

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Section: Discussionsupporting

confidence: 83%

Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations

Silva

Araújo

Fernandes

et al. 2016

AGE

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“…There is no doubt that physical activity improves health in patients suff ering from type 2 diabetes [ 26 , 27 ] , whereas the infl uence of physical activity on the immune system is controversially discussed. On the one hand, regular moderate exercise seems to increase immune function and decrease disease susceptibility [ 28 -30 ] , on the other hand, comparing athletes with non-active persons, no diff erences in immune parameters could be found [ 31 , 32 ] and exercise training in untrained persons did not alter immune function [ 33 ] . To gain an insight into the complex interaction of obesity, type 2 diabetes, adipocytokines, immune system and physical activity, we investigated the infl uence of endurance exercise on the release of the adipocytokines leptin, resistin and adiponectin as well as the immune status of overweight men suff ering from non-insulin dependent type 2 diabetes.…”

mentioning

confidence: 99%

Endurance Exercise Alters Cellular Immune Status and Resistin Concentrations in Men Suffering from Non-insulin-dependent Type 2 Diabetes

Wenning

Kreutz

Schmidt

et al. 2013

Exp Clin Endocrinol Diabetes

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It has been demonstrated that alterations of adipocytokines can alter immune status in type 2 diabetes. The present study investigated changes of adipocytokine plasma concentrations and cellular immune status in overweight men, suffering from non-insulin dependent type 2 diabetes (n=14, age 61.0±8.7 years, BMI 31.1±3.5 kg/cm2). Subjects underwent a 3 months endurance exercise intervention (twice per week for up to 45 min) cycling at a heart rate corresponding to a 2 mmol/l lactate threshold. Before and after the intervention testing for adipocytokines (leptin, adiponectin, resistin) and cellular immune status (including T memory-cells and regulative T-cells) was performed by RIA and FACS accordingly.The exercise intervention improved anthropometric and metabolic parameters of all subjects. We observed a significant decline for resistin and for the CD19+ B-cells. The CD4+CD25+CD127low Treg-cells decreased, however not statistically significant. All other parameters remained unchanged.In conclusion, even though only training twice a week, the exercise affected parts of the cellular immune system as well as resistin levels in men suffering from non-insulin dependent type 2 diabetes.

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“…Studies on the immunological effects of aerobic training on the CD4/CD8 ratio in HIV-negative people showed conflicting results as well. Several studies observed no change [30, 31], while others found a positive alteration of CD4/CD8 ratio [32]. …”

Section: Discussionmentioning

confidence: 99%

Moderate endurance training (marathon-training) – effects on immunologic and metabolic parameters in HIV-infected patients: the 42 KM cologne project

et al. 2017

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BackgroundImproved treatment options of HIV have resulted in regular physical activities of many HIV-infected patients. However, data on effects of sports in HIV-patients are scarce.Methods21 HIV-infected persons were monitored prospectively while preparing for a marathon run. Multiple parameters with regard to immunology, quality of life and metabolism were measured at 4 time points (at baseline 1 year before the marathon run, 3 and 6 months after beginning of training, and immediately before marathon).Results13 out of 21 participants completed the marathon (12 male, 1 female; median age 42 years [27–50]; CD4 = 620/μl [146–1268]; 11 were on ART since 3.5 years [1–7]). 8 participants ceased training early. All reasons for stopping (besides one pre-existing metatarsal fracture) were not regarded as training-related (e.g. time limitation n = 3; newly diagnosed anal cancer n = 1; personal reasons/unknown n = 3).We observed a significant increase in absolute CD4-T-cells (620/μl [146–1268] vs. 745 [207–1647]; p = 0.001) with simultaneous decrease of CD4-T-cell apoptosis (53% [47–64] vs. 32% [14–42]); p < 0.01). No effects on viral load independent of ART occurred. Systolic blood pressure and cholesterol improved significantly, although moderate and normal at baseline (cholesterol 185 mg/dl [98–250] vs. 167 [106–222], p = 0.02; RRsys 125 mmHg [100–145] vs. 120 [100–140], p = 0.01). Blood count, liver enzymes, creatinine and CK remained unchanged.ConclusionsThe results of this pilot study indicated improved metabolic and immunologic parameters in HIV-infected patients undergoing moderate endurance training. Although training effects or ART cannot be ultimately separated as underlying mechanisms, we conclude that marathon training is safe for HIV-infected patients and potentially improves general health.Trial registration DRKS00011592 (retrospectively registered on February 9th 2017).

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Effect of Resistance Training on Immunological Parameters of Healthy Elderly Women

Abstract: A 12-month moderate resistance training program increases muscle strength, but it does not change immune phenotypic and functional parameters of previously sedentary, clinically healthy, elderly women.

Cited by 40 publications

References 40 publications

Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations

Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations

Endurance Exercise Alters Cellular Immune Status and Resistin Concentrations in Men Suffering from Non-insulin-dependent Type 2 Diabetes

Moderate endurance training (marathon-training) – effects on immunologic and metabolic parameters in HIV-infected patients: the 42 KM cologne project

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