Effect of Reserpine (Serpasil) and Hydralazine (Apresoline) on Experimental Steroid Hypertension

Abstract

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Experimental Vascular Lesions in Desoxycorticosterone Hypertension in Rats

“…This led us to consider that the damage may be attributed to the rise in blood pressure. This is also supported by the observation of Gaunt,8) who has demonstrated that treatment of the DCA-treated rats with a depressor drug, hydralazine hydrochloride (apresoline), prevents vascular damage. The investigation by Byrom and Dodson 9) in which sudden strain placed on the arterial walls by repeated forced injections of Ringer's solution into the carotid artery produced focal necrosis of the small arteries of the kidney, must also be considered as an evidence to prove the causal relation between high arterial pressure and vascular damage.…”

Susceptibility to Experimental Pyelonephritis When Hormonal Hypertension Is Prevented by Hypotensive Drugs *

“…These studies lend support to the hypothesis that various injuries, including nephrosclerosis, predispose to human pyelonephritis and that pyelonephritis is superimposed upon hypertensive disease more frequently than is usually suspected. Others (3)(4)(5) have shown that reserpine and/or hydralazine, when given to rats with DCA-saline hypertension, will reduce blood pressure, delay or prevent renal and vascular pathological changes, and increase the average survival time. Masson, McCormack, Dustan and Corcoran (6) demonstrated a close association between blood pressure levels and the presence and character of the vascular lesions in rats with hydralazine-treated renal hypertension.…”