Effect of Reserpine on Milk Production and Serum Prolactin of Cows Hormonally Induced into Lactation

Collier, R. J.; Bauman, D. E.; Hays, R. L.

doi:10.3168/jds.s0022-0302(77)83960-x

Cited by 39 publications

(26 citation statements)

References 18 publications

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“…Including those results with the ones reported in this paper allows us to show that 93 % (n =45) of animals are successfully induced into lactation when reserpine is included in the regime compared to only 71 % when it is not included. This confirms the reports of Collier et al (1977) and Peel et al (1978) that addition of reserpine to the ovarian steroid treatment improves the success rate of the hormonal induction of lactation. The mode of action of reserpine in improving this success rate is uncertain.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

The Use of Oestrogen, Progesterone and Reserpine in the Artificial Induction of Lactation in Cattle

Peel¹,

Taylor²,

Robinson³

et al. 1979

Aust. Jnl. Of Bio. Sci.

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Oestradiol-17 p, progesterone and reserpine were utilized in three experiments in an attempt to improve the success rate and the magnitude of hormonally induced lactations. Onset of lactogenesis induced by steroid administration was measured by a surge in the lactose content of the mammary secretion and lactations were regarded as being successfully induced if milk yields exceeded 3 kg/day.In all experiments, the dose rate of oestradiol-17 p was standardized at the reduced level of 20 mg/day (approximately 0·05 mg/kg body weight daily), and progesterone maintained at 100 mg/day (approximately 0·25 mg/kg body weight daily) for the initial 7 days (days 1-7). The halving of the dose rate of oestradiol-17 p from the commonly used 0·1 mg/kg body weight daily eliminated the occurrence of noticeable physical injuries in the 60 animals so treated.Induced milk yields were not improved by either repeating the standard ovarian steroid treatment on days 16-22, extending the standard treatment for days 8-21 or continuing the steroid treatment at one-quarter the standard rate for days 8-21.Addition of reserpine to an oestradiol-17 p-progesterone treatment does improve the success rate of the hormonal induction of lactation. In experiment 1, 86% (n = 14) of heifers receiving reserpine were successfully induced into lactation compared to 45 % (n = 15) which were not.In experiments 2 and 3, 95 % (n = 19) of cows receiving both ovarian steroids and reserpine were successfully induced into lactation. However, when we consider only the milk yields of those cows sucessfully induced into lactation, reserpine (3 mg/day) administration on days 1, 6, 11, 16, 21 and 22-28, on days 22-28 alone, or on days 8, 10, 12 and 14 did not enhance induced yields.In one experiment all eleven cows failed to be induced into lactation and this was attributed to an inadequate dry period (25-43 days).

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Section: Discussionsupporting

confidence: 91%

“…However, reports on the effects of prolactin stimulators such as reserpine and thyrotrophin releasing hormone during the treatment period upon subsequent induced milk yields are conflicting (Mose et al 1975;Collier et al 1977;Peel et al 1978).…”

Section: Introductionmentioning

confidence: 99%

The Use of Oestrogen, Progesterone and Reserpine in the Artificial Induction of Lactation in Cattle

Peel¹,

Taylor²,

Robinson³

et al. 1979

Aust. Jnl. Of Bio. Sci.

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“…The success rates achieved in the current study are similar to those reported in previous studies [13,14]. The success rate for heifers (85%) was less than that (97%) reported previously [15].…”

Section: Lactation Induction Success Ratesupporting

confidence: 75%

Effect of mammary stimulation on dairy cows and heifers exposed to a lactation induction protocol

Ramgattie¹,

Siew²,

Diptee³

et al. 2014

OJAS

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Cows (n = 21), dried off for a minimum of 45 days, and nulliparous heifers (n = 26), at ages > 18 months old, were placed on a 12-day Lactation Induction (LI) protocol. One group of animals (including both cows and heifers) received 3-minute mammary gland stimulation, along with the LI protocol. Another group, again including both cows and heifers, received no stimulation. Only the LI protocol consisted of two injections of prostaglandin F2α (PGF2α; 25 mg) 11 days apart, followed by subcutaneous injections of 17ß-estradiol (0.1 mg/kg BW/d) and progesterone (0.25 mg/kg BW/d) beginning 1 day later and continuing for seven (7) days. After this step, all animals received another injection of PGF2α on day 8, followed by intramuscular injections of reserpine (5 mg/d) and dexamethasone (20 mg/d) on each of days 9 to 12. All animals were milked, beginning on day 13, for a period of 154 days. For all animals, the success rate for lactation induction was 78% ± 6.3% and the mean weekly milk yield was 78.2 kg. Neither value was affected by mammary stimulation. Parity did not significantly impact on the success rate, but it did affect the mean weekly milk yield. Milk yield varied significantly (p < 0.001) with week, peaking during week 9. Peak milk production and persistency were 101.6 kg ± 5.9 kg and 16.9 weeks ± 2.4 weeks respectively, with neither being significantly (α = 0.05 level) affected by stimulation or by parity. However, heifers (at 8.2 weeks ± 1.0 week) tended (p = 0.1) to reach peak milk production earlier than cows (at 10.7 weeks ± 1.3). The milk produced was sold at a net profit per animal treated of $2206.31 TT. Hence, one can conclude that a Lactation Induction protocol can be a useful management tool to increase production and profitability of dairy operations in the tropics.

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“…Prior to parturition, estrogen is one of the first hormones to increase in circulation, indicating a role for estrogen in lactogenesis (Akers, 2002). Indeed, administration of exogenous estrogen has been used to induce lactation in both pregnant and non-pregnant dairy cattle (Meites, 1961;Smith & Schanbacher, 1973;Howe et al, 1975;Collier et al, 1977). Estrogen also stimulates the anterior pituitary gland to secrete PRL, and it increases the expression of PRL receptors in the mammary epithelium (Tucker, 2000).…”

Section: Ovarian Hormonesmentioning

confidence: 99%

Regulation of Mammary Development as It Relates to Changes in Milk Production Efficiency

Wall¹,

McFadden²

2012

Milk Production - An Up-to-Date Overview of Animal Nutrition, Management and Health

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Effect of Reserpine on Milk Production and Serum Prolactin of Cows Hormonally Induced into Lactation

Cited by 39 publications

References 18 publications

The Use of Oestrogen, Progesterone and Reserpine in the Artificial Induction of Lactation in Cattle

The Use of Oestrogen, Progesterone and Reserpine in the Artificial Induction of Lactation in Cattle

Effect of mammary stimulation on dairy cows and heifers exposed to a lactation induction protocol

Regulation of Mammary Development as It Relates to Changes in Milk Production Efficiency

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