Effect of reserpine and tetrabenazine on tremorine analgesia in mice

Vh, Sethy; Naik,; Uk, Sheath

doi:10.1007/bf00422700

Cited by 5 publications

(1 citation statement)

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“…Furthermore, Collier (1965) has stressed that morphine tolerance is a consequence of an adaptive increase of receptors for particular neurohumors. That some neurohumors, particularly 5-HT and catecholamines, are involved in tremorine analgesia too has been demonstrated in our earlier study (Sethy et al, 1972) where it was shown that depletion of these amines by reserpine and tetrabenazine decreased analgesic response (i.e., increased EDso) to tremorine.…”

Section: Discussionmentioning

confidence: 81%

Possible involvement of 5-hydroxytryptamine and cyclic-AMP in tolerance to tremorine analgesia in mice

1977

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The phenomenon of tolerance to the analgesic action of tremorine in mice was studied by the hot-plate and tail-clip methods. Reduction in 5-HT levels in brain by parachlorophenylalamine pretreatment decreased the ED50 of tremorine analgesia in tremorine tolerant mice. 5-Hydroxyptophan, L-Dopa or alpha-methyl-para-tyrosine did not influence the analgesic response to tremorine in tremorine tolerant animals. However, theophylline was found to enhance the tolerance to tremorine analgesia. Brain 5-HT and cAMP are probably involved in tremorine tolerance, whereas neither noradrenaline nor dopamine is involved in the phenomenon.

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Section: Discussionmentioning

confidence: 81%