Effect of reserpine analogues on tissue serotonin

Garattini, S.; Kato, Ryo; Valzelli, L.

doi:10.1007/bf02158100

Cited by 36 publications

(34 citation statements)

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“…Except for the existence of a pair of aromatic 210 residues separated by a hydrophilic one (Tyr-TyrHis), this sequence bears no similarities whatever to MSH-ACTH (1-13) or to human leukocyte interferon (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). The only possible molecular sandwich found on PFSH was a sequence in which a Cys separated two Tyr [ 181.…”

Section: Resultsmentioning

confidence: 99%

“…This Cys is involved in forming a disulfide bridge in the natural conformation and so is unavailable to participate as part of an active site [20]. In any case the sequence of which these residues are a part (28-36) is not homologous to MSH-ACTH (1-13) or human leukocyte interferon (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) …”

Section: Resultsmentioning

confidence: 99%

“…Model building with CPK models suggests the further possibility that, like MSH and ACTH [ 1 l], the molecular sandwich on human leukocyte interferon may bind histamine. Since SHT and histamine are integrally involved in immunological reactions of many kinds [34,35], their modulation of interferon activity would not be unlikely. It is also noteworthy that the tryptophan peptide of myelin basic protein and LHRH are known to cause experimental autoimmune diseases in the presence of mummy1 dipeptide [36-391, which has been shown to be a SHT-like substance [40,41].…”

Section: Discussionmentioning

confidence: 99%

“…Note that it retains the same components and structure of the other molecular sandwiches although differing in absolute sequence. Other homologies between MSH-ACTH (l-13) and tryptophan peptide, LHRH, human leukocyte interferon (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40), and human fibroblast interferon (28-40) are indicated by single underlines. Note that while human fibroblast interferon (28-40) has many shared residues with human leukocyte interferon (28-40), it lacks a molecular sandwich and has a few other similarities to MSH-ACTH (1-13).…”

Section: Methodsmentioning

confidence: 99%

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‘Molecular sandwiches’ as a basis for structural and functional similarities of interferons, MSH, ACTH, LHRH, myelin basic protein, and albumins

Root‐Bernstein

1984

FEBS Letters

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Sequential similarities between the tryptohan peptide of myelin basic protein (residues 111–121), luteinizing hormone releasing hormone, melanotropin, adrenocorticotropin (residues 1–13), human leukocyte interferon (residues 28–40), and various segments of human and bovine serum albumin and hen ovalbumin are presented. It is suggested that these structural similarities may explain observations concerning common functional characteristics such as serotonin modulation, immunological activity with the adjuvant muramyl dipeptide, immunological cross‐reactivity, and the possible MSH‐ACTH‐like activity of a pepsin‐derived peptide of interferon.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

‘Molecular sandwiches’ as a basis for structural and functional similarities of interferons, MSH, ACTH, LHRH, myelin basic protein, and albumins

Root‐Bernstein

1984

FEBS Letters

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“…Serotonin is present mainly in the brain, intestine, and blood platelets of mammals, and it has been postulated that it plays a physiologically important role in maintaining the regulatory functions of the brain and intestine (9). If 5-HK can be considered as a physiological metabolic product in tissues where the activities of the metabolizing enzymes are high, excitability of cells in these tissues would be altered when there is an excess accumulation of 5-HK.…”

Section: -Hekmentioning

confidence: 99%

Effects of 5-Hydroxykynurenamine, a New Serotonin Metabolite, on Isolated Dog Basilar Arteries

Toda

Tokuyama

Senoh

et al. 1974

Proc. Natl. Acad. Sci. U.S.A.

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Serotonin and 5-hydroxykynurenamine caused dose-related contractions in the spiral strips of dog basilar arteries. The potency of 5-hydroxykynurenamine was approximately 1/100 that of serotonin, the former frequently causing a transient relaxation preceding the contraction. The contractile responses to 5-hydroxykynurenamine and serotonin were attenuated by methysergi(le. Treatment with 5-hydroxykynurenamine inhibited the response to serotonin, and this inhibitory effect was not completely reversed by removal of 5-hydroxykvnurenamine from the bathing medium. The contractile response to K+ was only slightly attenuated by high concentrations of 5-hydroxykynurenamine. It appears that 5-hydroxykynurenamine and serotonin share receptors in dog basilar arteries and that the effect of serotonin is specifically antagonized by 5-hydroxykynurenamine.5-Hydroxykynurenamine (5-HK) was first found in mouse urine by Makino (1), who suggested that it was biologically active (2). Recently, Havaishi and Hirata (3, 4) isolated from rabbit brain and intestine a new tryptophan 2,3-dioxygenase which catalyzes the conversion of serotonin to 5-hydroxyformylkynurenamine, the latter being hydrolyzed to 5-HK by formamidase. They suggested that this process may be one of the major pathways of serotonin metabolism in the body.The present study was undertaken to determine and compare the effects and investigate interactions of 5-HK and serotonin on isolated dog basilar arteries, which are sensitive specifically to serotonin (5). MATERIALS AND METHODSTwenty-one mongrel dogs of both sexes were used. The method used has been described (6). Basilar arteries (0.3-0.5 mm outer diameter) were cut spirally into strips and then fixed vertically under a resting tension of 1.5 g in a muscle bath containing modified Ringers' solution. The solution was maintained at 37 ± 0.50 and gased with 95% 02 and 5% Co2. The uipper end of the strips was connected to the lever of a force-displacement transducer.5-HK hydrobromide was synthesized as follows. Melatonin was oxidized with sodium metaiodate in aqueous methanol containing sodium acetate, to give 3-acetamido-2'-formamido-5'-methoxypropiophenone which was hydrolyzed by boiling in hydrobromic acid. 5-HK hydrobromide was used unless otherwise mentioned. Serotonin creatinine sulfate (Wako chemicals), methysergide bimaleate (Deseril®, Sandoz), and dl-propranolol hydrochloride (Sumitomo) were used. 5-HK and serotonin were added directly to the bathing medium in cumulative concentrations at the time when the doseresponse curve was obtained. RESULTSSerotonin in concentrations ranging from 10-9 to 10-5 M caused a dose-related increase in the tension of basilar arterial strips (Fig. 1A). Contractile responses to serotonin were reproducible five times when preparations were repeatedly washed and equilibrated in normal solutions for 40-60 min.5-HEK (5 X 10-' to 5 X 10-5 M) caused slowly developing contractions in a dose-dependent manner (Fig. 1B). Doseresponse curves of 5-HK and serotonin are compared in Fig. 2. ...

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Biochemistry and Physiology of Serotonergic Transmission

Gershon

1977

Comprehensive Physiology

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THE CONCERN of biologists with serotonin is a relatively recent phenomenon. However, its historical roots are considerably older than knowledge of the substance itself. It had been known since the nineteenth century that a vasoconstrictor substance was liberated from clotted blood (112, 113). Early efforts in 1911 (531) to measure epinephrine in blood were Involvement in sleep P 1 ate 1 e t s Depression 487 Behavior 28, 40 CNS neurons 1,3,91,158,651, 713 Control of brain serotonin (and bio-407, 408, 434-436 543, 565 312, 357, 451, 594, 743 synthesis) Gastrointestinal tract Pregnancy Schizophrenia and CNS disease Psychoactive compounds Distribution in various species Receptors Determination Endocrines Ontogeny Invertebrates Thermoregulation Turnover Migraine Depletors Transport and storage Inflammation and hypersensitivity General

show abstract

Effect of reserpine analogues on tissue serotonin

Cited by 36 publications

References 1 publication

‘Molecular sandwiches’ as a basis for structural and functional similarities of interferons, MSH, ACTH, LHRH, myelin basic protein, and albumins

‘Molecular sandwiches’ as a basis for structural and functional similarities of interferons, MSH, ACTH, LHRH, myelin basic protein, and albumins

Effects of 5-Hydroxykynurenamine, a New Serotonin Metabolite, on Isolated Dog Basilar Arteries

Biochemistry and Physiology of Serotonergic Transmission

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