Effect of Rescue Breathing During Cardiopulmonary Resuscitation on Lung Function After Restoration of Spontaneous Circulation in a Porcine Model of Prolonged Cardiac Arrest*

Abstract

Appropriate rescue breathing during cardiopulmonary resuscitation does not influence the prognosis of cardiac arrest or the hemodynamics after restoration of spontaneous circulation but can improve lung function and alleviate lung injury.

Variations of Postresuscitation Lung Function after Thrombolysis Therapy in a Cardiac Arrest Porcine Model Caused by Pulmonary Thromboembolism

“…Data of the lung function of patients with PTE have been ongoing for a long time[192021] and also the data of heart arrest. [2223] However, the study about CPR with thrombolysis of CA caused by PTE was reported rarely. Based on this, we performed CPR with thrombolysis in a CA porcine model caused by PTE to investigate the success rate of ROSC, short-time survival rate, and the pulmonary function variations.…”

“…The Raw was a transient increase which was different from CA model caused by ventricular fibrillation. [22] It may attribute to platelet aggregation, endothelial cell injury, release of inflammatory mediators such as serotonin, histamine, bradykinin, platelet activating factor, and endothelin which could cause bronchial smooth muscle contraction. The EVLWI and PVPI are predicators for the acute lung injury.…”

Should unobstructed gasping be facilitated and confirmed before administering adrenaline, otherwise, give titrated vasopressin?

“…High-impulse CPR with its high-velocity short duration compression phase and longer duration decompression phase (or duty cycle adequately < 50%) not only produces superior hemodynamics but also apparently produces substantial compression-induced ventilation when the airway is unobstructed (i.e, when intubated) [3,4,5].…”

“…it requires at least 50 mm [3] or more depending on the size of the chest for the displacement of A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT enough air adequately above dead space. Complete recoil cannot be achieved when performing effective-depth chest compressions at a 100/min rate, 50-mm compression depth and 50% duty cycle (or without high-impulse CPR) [9].…”

Ventilation and gas exchange management after cardiac arrest

“…In a pig model experimental study, CPR with continuous compression cause the increase of EVLW, lung injury score and resistance comparing with the 30:2 compression/rescue ventilation CPR group but not affect the prognosis and hemodynamic after CPR [17].…”